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@article{Gu:2022:10.1002/adma.202200048,
author = {Gu, L and Duan, Z and Chen, X and Li, X and Luo, Q and Bhamra, A and Pan, D and Zhu, H and Tian, X and Chen, R and Gu, Z and Zhang, H and Qian, Z and Gong, Q and Luo, K},
doi = {10.1002/adma.202200048},
journal = {Advanced Materials},
pages = {1--14},
title = {A transformable amphiphilic and block polymer-dendron conjugate for enhanced tumor penetration and retention with cellular homeostasis perturbation via membrane flow.},
url = {http://dx.doi.org/10.1002/adma.202200048},
volume = {34},
year = {2022}
}

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TY  - JOUR
AB  - Efficient penetration and retention of therapeutic agents in tumor tissues can be realized through rational design of drug delivery systems. Herein, we present a polymer-dendron conjugate, POEGMA-b-p(GFLG-Dendron-Ppa) (GFLG-DP), which allows cathepsin B (CTSB)-triggered stealthy-to-sticky structural transformation. The compositions and ratios were optimized through dissipative particle dynamics simulations. GFLG-DP displayed tumor-specific transformation and consequently released dendron-Ppa was found to effectively accumulate on the tumor cell membrane. The interaction between dendron-Ppa and the tumor cell membrane resulted in intracellular and intercellular transport via membrane flow, thus achieving efficient deep penetration and prolonged retention of therapeutic agents in solid tumor tissues. Meanwhile, the interaction of dendron-Ppa with endoplasmic reticulum disrupted the cell homeostasis, making tumor cells more vulnerable and susceptible to the photodynamic therapy. This platform represents a versatile approach to augmenting the tumor therapeutic efficacy of a nanomedicine via manipulation of its interactions with tumor membrane systems. This article is protected by copyright. All rights reserved.
AU  - Gu,L
AU  - Duan,Z
AU  - Chen,X
AU  - Li,X
AU  - Luo,Q
AU  - Bhamra,A
AU  - Pan,D
AU  - Zhu,H
AU  - Tian,X
AU  - Chen,R
AU  - Gu,Z
AU  - Zhang,H
AU  - Qian,Z
AU  - Gong,Q
AU  - Luo,K
DO  - 10.1002/adma.202200048
EP  - 14
PY  - 2022///
SN  - 0935-9648
SP  - 1
TI  - A transformable amphiphilic and block polymer-dendron conjugate for enhanced tumor penetration and retention with cellular homeostasis perturbation via membrane flow.
T2  - Advanced Materials
UR  - http://dx.doi.org/10.1002/adma.202200048
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35170102
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adma.202200048
UR  - http://hdl.handle.net/10044/1/94980
VL  - 34
ER  -

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