Imperial College London
Alternate

ProfessorRongjunChen

Faculty of Engineering, Department of Chemical Engineering

Professor of Biomaterials Engineering
 
 
 
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Contact

 

+44 (0)20 7594 2070rongjun.chen Website

 
 
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Location

 

408ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2022:10.1002/adma.202210161,
author = {Li, Y and Duan, Z and Pan, D and Ren, L and Gu, L and Li, X and Xu, G and Zhu, H and Zhang, H and Gu, Z and Chen, R and Gong, Q and Wu, Y and Luo, K},
doi = {10.1002/adma.202210161},
journal = {Advanced Materials},
pages = {1--14},
title = {Attenuating metabolic competition of tumor cells for favoring the nutritional demand of immune cells by a branched polymeric drug delivery system},
url = {http://dx.doi.org/10.1002/adma.202210161},
volume = {35},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tumor cells are dominant in the nutritional competition in the tumor microenvironment (TME), and their metabolic abnormalities often lead to microenvironmental acidosis and nutrient deprivation, thereby impairing the function of immune cells and diminishing the anti-tumor therapeutic effect. Herein, we report a branched polymeric conjugate and its efficacy in attenuating the metabolic competition of tumor cells. Compared with the control nanoparticles prepared from its linear counterpart, the branched conjugate-based nanoparticles (branched NPs) could more efficiently accumulate in the tumor tissue and interfere with the metabolic processes of tumor cells to increase the concentration of essential nutrients and reduce the level of immunosuppressive metabolites in the TME, thus creating a favorable environment for infiltrated immune cells. Its combined treatment with an immune checkpoint inhibitor (ICI) achieved an enhanced anti-tumor effect. Our work presents a promising approach for targeting the metabolic competition in the TME to enhance the chemo-immunotherapeutic effect against cancers.
AU  - Li,Y
AU  - Duan,Z
AU  - Pan,D
AU  - Ren,L
AU  - Gu,L
AU  - Li,X
AU  - Xu,G
AU  - Zhu,H
AU  - Zhang,H
AU  - Gu,Z
AU  - Chen,R
AU  - Gong,Q
AU  - Wu,Y
AU  - Luo,K
DO  - 10.1002/adma.202210161
EP  - 14
PY  - 2022///
SN  - 0935-9648
SP  - 1
TI  - Attenuating metabolic competition of tumor cells for favoring the nutritional demand of immune cells by a branched polymeric drug delivery system
T2  - Advanced Materials
UR  - http://dx.doi.org/10.1002/adma.202210161
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adma.202210161
UR  - http://hdl.handle.net/10044/1/101294
VL  - 35
ER  -
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