Imperial College London
Alternate

ProfessorRongjunChen

Faculty of Engineering, Department of Chemical Engineering

Professor of Biomaterials Engineering
 
 
 
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Contact

 

+44 (0)20 7594 2070rongjun.chen Website

 
 
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Location

 

408ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chen:2016:10.1021/acsami.6b05041,
author = {Chen, S and Chen, R},
doi = {10.1021/acsami.6b05041},
journal = {ACS Applied Materials and Interfaces},
pages = {22457--22467},
title = {A virus-mimicking, endosomolytic liposomal system for efficient, pH-triggered intracellular drug delivery},
url = {http://dx.doi.org/10.1021/acsami.6b05041},
volume = {8},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A novel multifunctional liposomal delivery platform has been developed to resemble the structural and functional traits of an influenza virus. Novel pseudopeptides were prepared to mimic the pH-responsive endosomolytic behavior of influenza viral peptides through grafting a hydrophobic amino acid, l-phenylalanine, onto the backbone of a polyamide, poly(l-lysine isophthalamide), at various degrees of substitution. These pseudopeptidic polymers were employed to functionalize the surface of cholesterol-containing liposomes that mimic the viral envelope. By controlling the cholesterol proportion as well as the concentration and amphiphilicity of the pseudopeptides, the entire payload was rapidly released at endosomal pHs, while there was no release at pH 7.4. A pH-triggered, reversible change in liposomal size was observed, and the release mechanism was elucidated. In addition, the virus-mimicking nanostructures efficiently disrupted the erythrocyte membrane at pH 6.5 characteristic of early endosomes, while they showed negligible cytotoxic effects at physiological pH. The efficient intracellular delivery of the widely used anticancer drug doxorubicin (DOX) by the multifunctional liposomes was demonstrated, leading to significantly increased potency against HeLa cancer cells over the DOX-loaded bare liposomes. This novel virus-mimicking liposomal system, with the incorporated synergy of efficient liposomal drug release and efficient endosomal escape, is favorable for efficient intracellular drug delivery.
AU  - Chen,S
AU  - Chen,R
DO  - 10.1021/acsami.6b05041
EP  - 22467
PY  - 2016///
SN  - 1944-8244
SP  - 22457
TI  - A virus-mimicking, endosomolytic liposomal system for efficient, pH-triggered intracellular drug delivery
T2  - ACS Applied Materials and Interfaces
UR  - http://dx.doi.org/10.1021/acsami.6b05041
UR  - https://pubs.acs.org/doi/10.1021/acsami.6b05041
UR  - http://hdl.handle.net/10044/1/39718
VL  - 8
ER  -
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