Imperial College London

Professor Sir Roy Anderson FRS, FMedSci

Faculty of MedicineSchool of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3399roy.anderson

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)20 7594 9162

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

477 results found

Asbjornsdottir KH, Ajjampur SSR, Anderson RM, Bailey R, Gardiner I, Halliday KE, Ibikounle M, Kalua K, Kang G, Littlewood DTJ, Luty AJF, Means AR, Oswald W, Pullan RL, Sarkar R, Schar F, Szpiro A, Truscott JE, Werkman M, Yard E, Walson JLet al., 2018, Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol, PLOS NEGLECTED TROPICAL DISEASES, Vol: 12, ISSN: 1935-2735

JOURNAL ARTICLE

Davis EL, Danon L, Prada JM, Gunawardena SA, Truscott JE, Vlaminck J, Anderson RM, Levecke B, Morgan ER, Hollingsworth TDet al., 2018, Seasonally timed treatment programs for Ascaris lumbricoides to increase impact-An investigation using mathematical models, PLOS NEGLECTED TROPICAL DISEASES, Vol: 12, ISSN: 1935-2735

JOURNAL ARTICLE

Farrell SH, Anderson RM, 2018, Helminth lifespan interacts with noncompliance in reducing the effectiveness of anthelmintic treatment, PARASITES & VECTORS, Vol: 11, ISSN: 1756-3305

JOURNAL ARTICLE

Hadjichrysanthou C, Ower AK, de Wolf F, Anderson RMet al., 2018, The development of a stochastic mathematical model of Alzheimer's disease to help improve the design of clinical trials of potential treatments, PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

Turner HC, Toor J, Hollingsworth TD, Anderson RMet al., 2018, Economic Evaluations of Mass Drug Administration: The Importance of Economies of Scale and Scope, CLINICAL INFECTIOUS DISEASES, Vol: 66, Pages: 1298-1303, ISSN: 1058-4838

JOURNAL ARTICLE

Werkman M, Wright JE, Truscott JE, Easton AV, Oliveira RG, Toor J, Ower A, Asbjornsdottir KHA, Means AR, Farrell SH, Walson JL, Anderson RMet al., 2018, Testing for soil-transmitted helminth transmission elimination: Analysing the impact of the sensitivity of different diagnostic tools, PLOS NEGLECTED TROPICAL DISEASES, Vol: 12, ISSN: 1935-2735

JOURNAL ARTICLE

Wright JE, Werkman M, Dunn JC, Anderson RMet al., 2018, Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review, PARASITES & VECTORS, Vol: 11, ISSN: 1756-3305

JOURNAL ARTICLE

Anderson R, Farrell S, Turner H, Walson J, Donnelly CA, Truscott Jet al., 2017, Assessing the interruption of the transmission of human helminths with mass drug administration alone: optimizing the design of cluster randomized trials, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Anderson RM, Hadjichrysanthou C, Evans S, Wong MMet al., 2017, Why do so many clinical trials of therapies for Alzheimer's disease fail?, LANCET, Vol: 390, Pages: 2327-2329, ISSN: 0140-6736

JOURNAL ARTICLE

Bettis AA, Dunn JC, Wyine NY, Lwin AMM, Maung NS, Anderson RMet al., 2017, UNDERSTANDING ADHERENCE/COMPLIANCE TO NEGLECTED TROPICAL DISEASE MASS DRUG ADMINISTRATION PROGRAMS: AN IMPORTANT TOOL FOR THE ENDGAME, 66th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 167-168, ISSN: 0002-9637

CONFERENCE PAPER

Coffeng LE, Truscott JE, Farrell SH, Turner HC, Sarkar R, Kang G, de Vlas SJ, Anderson RMet al., 2017, Comparison and validation of two mathematical models for the impact of mass drug administration on Ascaris lumbricoides and hookworm infection, EPIDEMICS, Vol: 18, Pages: 38-47, ISSN: 1755-4365

JOURNAL ARTICLE

Dunn JC, Bettis AA, Wyine NY, Lwin AMM, Lwin ST, Su KK, Sein MM, Tun A, Maung NS, Anderson RMet al., 2017, A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Dunn JC, Bettis AA, Wyine NY, Lwin AMM, Maung NS, Anderson RMet al., 2017, RISK FACTORS ASSOCIATED WITH PREDISPOSITION TO SOIL-TRANSMITTED HELMINTH INFECTION IN SOUTHERN MYANMAR, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 352-352, ISSN: 0002-9637

CONFERENCE PAPER

Dunn JC, Bettis AA, Wyine NY, Lwin AMM, Maung NS, Anderson RMet al., 2017, SOIL-TRANSMITTED HELMINTH INFECTION AND MASS DRUG ADMINISTRATION IN MYANMAR: ARE ADULTS PERPETUATING TRANSMISSION?, 66th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 614-614, ISSN: 0002-9637

CONFERENCE PAPER

Easton AV, Dahlstrom E, Porcella SF, Oliveira RG, Wang J, Gao S, Davis RE, Njenga SM, Mwandawiro C, Webster JP, Anderson RM, Nutman TBet al., 2017, WHOLE GENOME SEQUENCING OF ASCARIS LUMBRICOIDES WORMS REVEALS CHANGES IN SPACE AND TIME, 66th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 598-599, ISSN: 0002-9637

CONFERENCE PAPER

Easton AV, Oliveira RG, Walker M, O'Connell EM, Njenga SM, Mwandawiro CS, Webster JP, Nutman TB, Anderson RMet al., 2017, Sources of variability in the measurement of Ascaris lumbricoides infection intensity by Kato-Katz and qPCR, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Easton AV, Shyu C, Mwandawiro CS, Njenga SM, Kihara JH, Mwatele C, Quinones M, Davis J, Belkaid Y, Oliveira RG, Lamberton PH, Anderson RM, Nutman TBet al., 2017, ASSESSING THE IMPACT OF MASS DEWORMING ON CO-INFECTIONS WITH OTHER PARASITES AND COMMENSALS USING MOLECULAR TECHNIQUES, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 585-585, ISSN: 0002-9637

CONFERENCE PAPER

Farrell SH, Truscott JE, Anderson RM, 2017, The importance of patient compliance in repeated rounds of mass drug administration (MDA) for the elimination of intestinal helminth transmission, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Kepha S, Mwandawiro CS, Anderson RM, Pullan RL, Nuwaha F, Cano J, Njenga SM, Odiere MR, Allen E, Brooker SJ, Nikolay Bet al., 2017, Impact of single annual treatment and four-monthly treatment for hookworm and Ascaris lumbricoides, and factors associated with residual infection among Kenyan school children, INFECTIOUS DISEASES OF POVERTY, Vol: 6, ISSN: 2049-9957

JOURNAL ARTICLE

Lawrence E, Vegvari C, Ower A, Hadjichrysanthou C, De Wolf F, Anderson RMet al., 2017, A Systematic Review of Longitudinal Studies Which Measure Alzheimer's Disease Biomarkers, JOURNAL OF ALZHEIMERS DISEASE, Vol: 59, Pages: 1359-1379, ISSN: 1387-2877

JOURNAL ARTICLE

Levecke B, Ghebretinsae AH, Anderson RM, Berkvens D, Vlaminck J, Devleesschauwer B, Speybroeck N, Vercruysse J, Van Aelst Set al., 2017, GUIDANCE IN DESIGNING SURVEYS FOR MONITORING SURVEYS FOR MONITORING THE PROGRESS OF SCHOOL-BASED DEWORMING PROGRAMS TO CONTROL SOIL-TRANSMITTED HELMINTHIASIS, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 356-356, ISSN: 0002-9637

CONFERENCE PAPER

Oliveira RG, Easton AV, Kihara JH, Mwatele C, Njenga SM, Mwandawiro CS, Lamberton PH, Brooker SJ, Anderson RMet al., 2017, REPEATED ROUNDS OF MASS DEWORMING ADMINISTRATION STILL LEAVE HOUSEHOLD CLUSTERING OF SOIL-TRANSMITTED HELMINTH INFECTIONS, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 354-354, ISSN: 0002-9637

CONFERENCE PAPER

Oliveira RG, Easton AV, Lamberton PH, Vlaminck J, Beaumier CM, Kihara JH, Njenga SM, Mwandawiro CS, Geldhof P, Drakeley C, Brooker SJ, Anderson RMet al., 2017, ENZYME-LINKED IMMUNOSORBENT ASSAY AS AN ENDGAME DIAGNOSTIC METHOD FOR SOIL-TRANSMITTED HELMINTH INFECTIONS, 66th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 614-614, ISSN: 0002-9637

CONFERENCE PAPER

Ower AK, Hadjichrysanthou C, Gras L, Goudsmit J, Anderson RM, de Wolf F, Alzheimers Disease Neuroimaging Initiativeet al., 2017, Temporal association patterns and dynamics of amyloid-β and tau in Alzheimer's disease., Eur J Epidemiol

The elusive relationship between underlying pathology and clinical disease hampers diagnosis of Alzheimer's disease (AD) and preventative intervention development. We seek to understand the relationship between two classical AD biomarkers, amyloid-β1-42 (Aβ1-42) and total-tau (t-tau), and define their trajectories across disease development, as defined by disease onset at diagnosis of mild cognitive impairment (MCI). Using longitudinal data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we performed a correlation analysis of biomarkers CSF Aβ1-42 and t-tau, and longitudinal quantile analysis. Using a mixed effects model, with MCI onset as an anchor, we develop linear trajectories to describe the rate of change across disease development. These trajectories were extended through the incorporation of data from cognitively normal, healthy adults (aged 20-62 years) from the literature, to fit sigmoid curves by means of non-linear least squares estimators, to create curves encompassing the 50 years prior to MCI onset. A strong right-angled relationship between the biomarkers Aβ1-42 and t-tau is detected, implying a highly non-linear relationship. The rate of change of Aβ1-42 is correlated with the baseline concentration per quantile, reflecting a reduction in the rate of loss across disease within subjects. Regression models reveal significant amyloid loss relative to MCI onset (- 2.35 pg/mL/year), compared to minimal loss relative to AD onset (- 0.97 pg/mL/year). Tau accumulates consistently relative to MCI and AD onset, (2.05 pg/mL/year) and (2.46 pg/mL/year), respectively. The fitted amyloid curve shows peak loss of amyloid 8.06 years prior to MCI diagnosis, while t-tau exhibits peak accumulation 14.17 years following MCI diagnosis, with the upper limit not yet reached 30 years post diagnosis. Biomarker trajectories aid unbiased, objective assessment of disease progression. Q

JOURNAL ARTICLE

Sarkar R, Rose A, Mohan VR, Ajjampur SSR, Veluswamy V, Srinivasan R, Muliyil J, Rajshekhar V, George K, Balraj V, Grassly NC, Anderson RM, Brooker SJ, Kang Get al., 2017, Study design and baseline results of an open-label cluster randomized community-intervention trial to assess the effectiveness of a modified mass deworming program in reducing hookworm infection in a tribal population in southern India, CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS, Vol: 5, Pages: 49-55, ISSN: 2451-8654

JOURNAL ARTICLE

Sarkar R, Truscott JE, Veluswamy V, Roy S, Rose A, Srinivasan R, Mohan VR, Balraj V, Muliyil J, Kang G, Anderson RMet al., 2017, UNDERSTANDING THE EPIDEMIOLOGY OF HOOKWORM INFECTION IN A LOW-TRANSMISSION SETTING IN SOUTHERN INDIA: ANALYSIS OF DATA FROM A CLUSTER-RANDOMIZED MASS DEWORMING TRIAL, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 355-355, ISSN: 0002-9637

CONFERENCE PAPER

Srinivasa Rao ASR, Anderson RM, 2017, Helminth Dynamics: Mean Number of Worms, Reproductive Rates, Vol: 36, Pages: 397-404, ISSN: 0169-7161

© 2017 Elsevier B.V. Understanding the mean number of worms and burden of soil transmitted helminth infections are considered as important parameters in formulating treatment strategies to eliminate worms among children who are effected by helminth infections (Anderson et al., 2015). We derive mean number of worms in a newly helminth infected population before secondary infections are started (population is closed). Further we bring analytical solutions. We also theoretically demonstrate computing net reproductive rates within and outside a human host.

JOURNAL ARTICLE

Stylianou A, Siddiqui AA, Anderson RM, 2017, MODELLING THE EFFECT OF A POTENTIAL VACCINE APPLICATION ON THE SCHISTOSOME PARASITE DYNAMICS, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 558-558, ISSN: 0002-9637

CONFERENCE PAPER

Toor J, Truscott JE, Alsallaq R, Werkman M, Turner HC, Gurarie D, Wright JE, Farrell SH, King CH, Anderson RMet al., 2017, ARE WE ON OUR WAY TO ACHIEVING THE 2020 GOALS FOR SCHISTOSOMIASIS MORBIDITY CONTROL USING CURRENT WHO GUIDELINES?, 66th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 394-395, ISSN: 0002-9637

CONFERENCE PAPER

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