Imperial College London

Professor Sir Roy Anderson FRS, FMedSci

Faculty of MedicineSchool of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
//

Contact

 

+44 (0)20 7594 3399roy.anderson

 
 
//

Assistant

 

Mrs Clare Mylchreest +44 (0)20 7594 9162

 
//

Location

 

LG35Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Publication Type
Year
to

451 results found

Anderson R, Farrell S, Turner H, Walson J, Donnelly CA, Truscott Jet al., 2017, Assessing the interruption of the transmission of human helminths with mass drug administration alone: optimizing the design of cluster randomized trials, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Anderson RM, Hadjichrysanthou C, Evans S, Wong MMet al., 2017, Why do so many clinical trials of therapies for Alzheimer's disease fail?, LANCET, Vol: 390, Pages: 2327-2329, ISSN: 0140-6736

JOURNAL ARTICLE

Coffeng LE, Truscott JE, Farrell SH, Turner HC, Sarkar R, Kang G, de Vlas SJ, Anderson RMet al., 2017, Comparison and validation of two mathematical models for the impact of mass drug administration on Ascaris lumbricoides and hookworm infection, EPIDEMICS, Vol: 18, Pages: 38-47, ISSN: 1755-4365

JOURNAL ARTICLE

Dunn JC, Bettis AA, Wyine NY, Lwin AMM, Lwin ST, Su KK, Sein MM, Tun A, Maung NS, Anderson RMet al., 2017, A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Easton AV, Oliveira RG, Walker M, O'Connell EM, Njenga SM, Mwandawiro CS, Webster JP, Nutman TB, Anderson RMet al., 2017, Sources of variability in the measurement of Ascaris lumbricoides infection intensity by Kato-Katz and qPCR, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Farrell SH, Truscott JE, Anderson RM, 2017, The importance of patient compliance in repeated rounds of mass drug administration (MDA) for the elimination of intestinal helminth transmission, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Kepha S, Mwandawiro CS, Anderson RM, Pullan RL, Nuwaha F, Cano J, Njenga SM, Odiere MR, Allen E, Brooker SJ, Nikolay Bet al., 2017, Impact of single annual treatment and four-monthly treatment for hookworm and Ascaris lumbricoides, and factors associated with residual infection among Kenyan school children, INFECTIOUS DISEASES OF POVERTY, Vol: 6, ISSN: 2049-9957

JOURNAL ARTICLE

Lawrence E, Vegvari C, Ower A, Hadjichrysanthou C, De Wolf F, Anderson RMet al., 2017, A Systematic Review of Longitudinal Studies Which Measure Alzheimer's Disease Biomarkers, JOURNAL OF ALZHEIMERS DISEASE, Vol: 59, Pages: 1359-1379, ISSN: 1387-2877

JOURNAL ARTICLE

Ower AK, Hadjichrysanthou C, Gras L, Goudsmit J, Anderson RM, de Wolf F, Alzheimers Disease Neuroimaging Initiativeet al., 2017, Temporal association patterns and dynamics of amyloid-β and tau in Alzheimer's disease., Eur J Epidemiol

The elusive relationship between underlying pathology and clinical disease hampers diagnosis of Alzheimer's disease (AD) and preventative intervention development. We seek to understand the relationship between two classical AD biomarkers, amyloid-β1-42 (Aβ1-42) and total-tau (t-tau), and define their trajectories across disease development, as defined by disease onset at diagnosis of mild cognitive impairment (MCI). Using longitudinal data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we performed a correlation analysis of biomarkers CSF Aβ1-42 and t-tau, and longitudinal quantile analysis. Using a mixed effects model, with MCI onset as an anchor, we develop linear trajectories to describe the rate of change across disease development. These trajectories were extended through the incorporation of data from cognitively normal, healthy adults (aged 20-62 years) from the literature, to fit sigmoid curves by means of non-linear least squares estimators, to create curves encompassing the 50 years prior to MCI onset. A strong right-angled relationship between the biomarkers Aβ1-42 and t-tau is detected, implying a highly non-linear relationship. The rate of change of Aβ1-42 is correlated with the baseline concentration per quantile, reflecting a reduction in the rate of loss across disease within subjects. Regression models reveal significant amyloid loss relative to MCI onset (- 2.35 pg/mL/year), compared to minimal loss relative to AD onset (- 0.97 pg/mL/year). Tau accumulates consistently relative to MCI and AD onset, (2.05 pg/mL/year) and (2.46 pg/mL/year), respectively. The fitted amyloid curve shows peak loss of amyloid 8.06 years prior to MCI diagnosis, while t-tau exhibits peak accumulation 14.17 years following MCI diagnosis, with the upper limit not yet reached 30 years post diagnosis. Biomarker trajectories aid unbiased, objective assessment of disease progression. Q

JOURNAL ARTICLE

Sarkar R, Rose A, Mohan VR, Ajjampur SSR, Veluswamy V, Srinivasan R, Muliyil J, Rajshekhar V, George K, Balraj V, Grassly NC, Anderson RM, Brooker SJ, Kang Get al., 2017, Study design and baseline results of an open-label cluster randomized community-intervention trial to assess the effectiveness of a modified mass deworming program in reducing hookworm infection in a tribal population in southern India, CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS, Vol: 5, Pages: 49-55, ISSN: 2451-8654

JOURNAL ARTICLE

Srinivasa Rao ASR, Anderson RM, 2017, Helminth Dynamics: Mean Number of Worms, Reproductive Rates, Handbook of Statistics, ISSN: 0169-7161

© 2017 Elsevier B.V. Understanding the mean number of worms and burden of soil transmitted helminth infections are considered as important parameters in formulating treatment strategies to eliminate worms among children who are effected by helminth infections (). We derive mean number of worms in a newly helminth infected population before secondary infections are started (population is closed). Further we bring analytical solutions. We also theoretically demonstrate computing net reproductive rates within and outside a human host.

JOURNAL ARTICLE

Truscott JE, Gurarie D, Alsallaq R, Toor J, Yoon N, Farrell SH, Turner HC, Phillips AE, Aurelio HO, Ferro J, King CH, Anderson RMet al., 2017, A comparison of two mathematical models of the impact of mass drug administration on the transmission and control of schistosomiasis, EPIDEMICS, Vol: 18, Pages: 29-37, ISSN: 1755-4365

JOURNAL ARTICLE

Truscott JE, Werkman M, Wright JE, Farrell SH, Sarkar R, Asbjornsdottir K, Anderson RMet al., 2017, Identifying optimal threshold statistics for elimination of hookworm using a stochastic simulation model, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Turner HC, Bettis AA, Dunn JC, Whitton JM, Hollingsworth D, Fleming FM, Anderson RMet al., 2017, Economic Considerations for Moving beyond the Kato-Katz Technique for Diagnosing Intestinal Parasites As We Move Towards Elimination, TRENDS IN PARASITOLOGY, Vol: 33, Pages: 435-443, ISSN: 1471-4922

JOURNAL ARTICLE

Turner HC, Toor J, Hollingsworth TD, Anderson RMet al., 2017, Economic evaluations of mass drug administration: The importance of economies of scale and scope., Clin Infect Dis

It is recognised that changing the current approaches for the control of the neglected tropical diseases will be needed to reach the World Health Organization's (WHO) 2020 goals. Consequently, it is important that economic evaluations of the alternative approaches are conducted. A vital component of such evaluations is the issue of how the intervention's costs should be incorporated. We discuss this issue - focusing on mass drug administration. We argue that the common approach of assuming an intervention's cost per treatment is constant, regardless of the number of individuals treated, is a misleading way to consider the delivery costs of mass drug administration due to the occurrence of economies/diseconomies of scale and scope. Greater care and consideration are required when the costs are incorporated into such analyses. Without this, these economic evaluations could potentially lead to incorrect policy recommendations.

JOURNAL ARTICLE

Turner HC, Truscott JE, Bettis AA, Farrell SH, Deol AK, Whitton JM, Fleming FM, Anderson RMet al., 2017, Evaluating the variation in the projected benefit of community-wide mass treatment for schistosomiasis: Implications for future economic evaluations, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Werkman M, Truscott JE, Toor J, Wright JE, Anderson RMet al., 2017, The past matters: estimating intrinsic hookworm transmission intensity in areas with past mass drug administration to control lymphatic filariasis, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Basáñez M-G, Anderson RM, 2016, Preface.

BOOK

Basanez M-G, Anderson RM, 2016, ADVANCES IN PARASITOLOGY Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part B PREFACE, Publisher: ELSEVIER ACADEMIC PRESS INC

BOOK

Dunn JC, Turner HC, Tun A, Anderson RMet al., 2016, Epidemiological surveys of, and research on, soil-transmitted helminths in Southeast Asia: a systematic review, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305

JOURNAL ARTICLE

Easton AV, Oliveira RG, O'Connell EM, Kepha S, Mwandawiro CS, Njenga SM, Kihara JH, Mwatele C, Odiere MR, Brooker SJ, Webster JP, Anderson RM, Nutman TBet al., 2016, Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305

JOURNAL ARTICLE

Hadjichrysanthou C, Cauet E, Lawrence E, Vegvari C, de Wolf F, Anderson RMet al., 2016, Understanding the within-host dynamics of influenza A virus: from theory to clinical implications, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 13, ISSN: 1742-5689

JOURNAL ARTICLE

Shuford KV, Turner HC, Anderson RM, 2016, Compliance with anthelmintic treatment in the neglected tropical diseases control programmes: a systematic review, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305

JOURNAL ARTICLE

Truscott JE, Turner HC, Farrell SH, Anderson RMet al., 2016, Soil-Transmitted Helminths: Mathematical Models of Transmission, the Impact of Mass Drug Administration and Transmission Elimination Criteria, ADVANCES IN PARASITOLOGY, VOL 94: MATHEMATICAL MODELS FOR NEGLECTED TROPICAL DISEASES: ESSENTIAL TOOLS FOR CONTROL AND ELIMINATION, PT B, Vol: 94, Pages: 133-198, ISSN: 0065-308X

JOURNAL ARTICLE

Turner HC, Truscott JE, Anderson RM, 2016, Cost-effectiveness of community-wide treatment for helminthiasis, Lancet Global Health, Vol: 4, Pages: E156-E156, ISSN: 2214-109X

JOURNAL ARTICLE

Turner HC, Truscott JE, Bettis AA, Hollingsworth TD, Brooker SJ, Anderson RMet al., 2016, Analysis of the population-level impact of co-administering ivermectin with albendazole or mebendazole for the control and elimination of Trichuris trichiura., Parasite Epidemiol Control, Vol: 1, Pages: 177-187, ISSN: 2405-6731

INTRODUCTION: Soil-transmitted helminth (STH) infections are predominately controlled by providing children with preventive chemotherapy with either albendazole or mebendazole. However, neither has a high efficacy against Trichuris trichiura. This low efficacy limits the overall effectiveness of the current STH control programmes against T. trichiura. It has been demonstrated that co-administering ivermectin with albendazole or mebendazole significantly increases the efficacy of current treatments, which may increase the overall effectiveness of control programmes. METHODS: Using a STH transmission mathematical model, we evaluated the potential impact of co-administering ivermectin with albendazole or mebendazole to treat T. trichiura within a preventive chemotherapy programme targeting children (2-15 year olds). We evaluated the impact in terms of reduction in prevalent infections, mean worm burden, and prevalence of heavy infections. RESULTS: Although the current treatment strategy reduced T. trichiura worm burden and prevalence of heavy infections, due to their poor efficacy the long term impact of preventive chemotherapy for children was smaller compared to the other STH. Co-administering ivermectin increased the projected impact of the preventive chemotherapy programme in terms of all three of the explored metrics, practically in high transmission settings. Furthermore, ivermectin co-administration greatly increased the feasibility of and timeframe for breaking transmission. CONCLUSIONS: Co-administering ivermectin notably increased the projected impact of preventive chemotherapy in high transmission settings and increased the feasibility for breaking transmission. This has important implications for control programmes, some of which may be shifting focus from morbidity control to interruption of transmission, and some of which may be logistically unable to provide preventive chemotherapy twice a year as recommended. However, the benefit of co-administerin

JOURNAL ARTICLE

Turner HC, Truscott JE, Fleming FM, Hollingsworth TD, Brooker SJ, Anderson RMet al., 2016, Cost-effectiveness of scaling up mass drug administration for the control of soil-transmitted helminths: a comparison of cost function and constant costs analyses, LANCET INFECTIOUS DISEASES, Vol: 16, Pages: 838-846, ISSN: 1473-3099

JOURNAL ARTICLE

Vegvari C, Cauet E, Hadjichrysanthou C, Lawrence E, Weverling G-J, de Wolf F, Anderson RMet al., 2016, Using Clinical Trial Simulators to Analyse the Sources of Variance in Clinical Trials of Novel Therapies for Acute Viral Infections, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Vegvari C, Hadjichrysanthou C, Cauet E, Lawrence E, Cori A, de Wolf F, Anderson RMet al., 2016, How Can Viral Dynamics Models Inform Endpoint Measures in Clinical Trials of Therapies for Acute Viral Infections?, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00152009&limit=30&person=true