Imperial College London

Professor Sir Roy Anderson FRS, FMedSci

Faculty of MedicineSchool of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3399roy.anderson

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)20 7594 9162

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

480 results found

Stylianou A, Siddiqui AA, Anderson RM, 2017, MODELLING THE EFFECT OF A POTENTIAL VACCINE APPLICATION ON THE SCHISTOSOME PARASITE DYNAMICS, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 558-558, ISSN: 0002-9637

CONFERENCE PAPER

Toor J, Truscott JE, Alsallaq R, Werkman M, Turner HC, Gurarie D, Wright JE, Farrell SH, King CH, Anderson RMet al., 2017, ARE WE ON OUR WAY TO ACHIEVING THE 2020 GOALS FOR SCHISTOSOMIASIS MORBIDITY CONTROL USING CURRENT WHO GUIDELINES?, 66th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 394-395, ISSN: 0002-9637

CONFERENCE PAPER

Truscott JE, Gurarie D, Alsallaq R, Toor J, Yoon N, Farrell SH, Turner HC, Phillips AE, Aurelio HO, Ferro J, King CH, Anderson RMet al., 2017, A comparison of two mathematical models of the impact of mass drug administration on the transmission and control of schistosomiasis, EPIDEMICS, Vol: 18, Pages: 29-37, ISSN: 1755-4365

JOURNAL ARTICLE

Truscott JE, Werkman M, Wright JE, Farrell SH, Sarkar R, Asbjornsdottir K, Anderson RMet al., 2017, Identifying optimal threshold statistics for elimination of hookworm using a stochastic simulation model, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Turner HC, Bettis AA, Dunn JC, Whitton JM, Hollingsworth D, Fleming FM, Anderson RMet al., 2017, Economic Considerations for Moving beyond the Kato-Katz Technique for Diagnosing Intestinal Parasites As We Move Towards Elimination, TRENDS IN PARASITOLOGY, Vol: 33, Pages: 435-443, ISSN: 1471-4922

JOURNAL ARTICLE

Turner HC, Truscott JE, Bettis AA, Farrell SH, Deol AK, Whitton JM, Fleming FM, Anderson RMet al., 2017, Evaluating the variation in the projected benefit of community-wide mass treatment for schistosomiasis: Implications for future economic evaluations, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Werkman M, Truscott JE, Toor J, Wright JE, Anderson RMet al., 2017, The past matters: estimating intrinsic hookworm transmission intensity in areas with past mass drug administration to control lymphatic filariasis, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Werkman M, Truscott JE, Wright JE, Toor J, Asbjornsdottir KH, Farrell SH, Walson JL, Anderson RMet al., 2017, ARE WE ON THE RIGHT TRACK? STOPPING CRITERIA FOR ENDING SOIL-TRANSMITTED HELMINTHS RANDOMIZED CLINICAL TRIALS, 66th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 560-560, ISSN: 0002-9637

CONFERENCE PAPER

Wright JE, Truscott J, Werkman M, Sarkar R, Kang G, Anderson RMet al., 2017, ASSESSING BETWEEN-VILLAGE HETEROGENEITY OF HOOKWORM TRANSMISSION IN A LOW-INTENSITY SETTING, 66th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 375-376, ISSN: 0002-9637

CONFERENCE PAPER

Basáñez M-G, Anderson RM, 2016, Preface.

BOOK

Basanez M-G, Anderson RM, 2016, ADVANCES IN PARASITOLOGY Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part B PREFACE, Publisher: ELSEVIER ACADEMIC PRESS INC

BOOK

Dunn JC, Turner HC, Tun A, Anderson RMet al., 2016, Epidemiological surveys of, and research on, soil-transmitted helminths in Southeast Asia: a systematic review, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305

JOURNAL ARTICLE

Easton AV, Oliveira RG, O'Connell EM, Kepha S, Mwandawiro CS, Njenga SM, Kihara JH, Mwatele C, Odiere MR, Brooker SJ, Webster JP, Anderson RM, Nutman TBet al., 2016, Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305

JOURNAL ARTICLE

Hadjichrysanthou C, Cauet E, Lawrence E, Vegvari C, de Wolf F, Anderson RMet al., 2016, Understanding the within-host dynamics of influenza A virus: from theory to clinical implications, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 13, ISSN: 1742-5689

JOURNAL ARTICLE

Shuford KV, Turner HC, Anderson RM, 2016, Compliance with anthelmintic treatment in the neglected tropical diseases control programmes: a systematic review, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305

JOURNAL ARTICLE

Truscott JE, Turner HC, Farrell SH, Anderson RMet al., 2016, Soil-Transmitted Helminths: Mathematical Models of Transmission, the Impact of Mass Drug Administration and Transmission Elimination Criteria, ADVANCES IN PARASITOLOGY, VOL 94: MATHEMATICAL MODELS FOR NEGLECTED TROPICAL DISEASES: ESSENTIAL TOOLS FOR CONTROL AND ELIMINATION, PT B, Vol: 94, Pages: 133-198, ISSN: 0065-308X

JOURNAL ARTICLE

Turner HC, Truscott JE, Anderson RM, 2016, Cost-effectiveness of community-wide treatment for helminthiasis, Lancet Global Health, Vol: 4, Pages: E156-E156, ISSN: 2214-109X

JOURNAL ARTICLE

Turner HC, Truscott JE, Bettis AA, Hollingsworth TD, Brooker SJ, Anderson RMet al., 2016, Analysis of the population-level impact of co-administering ivermectin with albendazole or mebendazole for the control and elimination of Trichuris trichiura., Parasite Epidemiol Control, Vol: 1, Pages: 177-187, ISSN: 2405-6731

INTRODUCTION: Soil-transmitted helminth (STH) infections are predominately controlled by providing children with preventive chemotherapy with either albendazole or mebendazole. However, neither has a high efficacy against Trichuris trichiura. This low efficacy limits the overall effectiveness of the current STH control programmes against T. trichiura. It has been demonstrated that co-administering ivermectin with albendazole or mebendazole significantly increases the efficacy of current treatments, which may increase the overall effectiveness of control programmes. METHODS: Using a STH transmission mathematical model, we evaluated the potential impact of co-administering ivermectin with albendazole or mebendazole to treat T. trichiura within a preventive chemotherapy programme targeting children (2-15 year olds). We evaluated the impact in terms of reduction in prevalent infections, mean worm burden, and prevalence of heavy infections. RESULTS: Although the current treatment strategy reduced T. trichiura worm burden and prevalence of heavy infections, due to their poor efficacy the long term impact of preventive chemotherapy for children was smaller compared to the other STH. Co-administering ivermectin increased the projected impact of the preventive chemotherapy programme in terms of all three of the explored metrics, practically in high transmission settings. Furthermore, ivermectin co-administration greatly increased the feasibility of and timeframe for breaking transmission. CONCLUSIONS: Co-administering ivermectin notably increased the projected impact of preventive chemotherapy in high transmission settings and increased the feasibility for breaking transmission. This has important implications for control programmes, some of which may be shifting focus from morbidity control to interruption of transmission, and some of which may be logistically unable to provide preventive chemotherapy twice a year as recommended. However, the benefit of co-administerin

JOURNAL ARTICLE

Turner HC, Truscott JE, Fleming FM, Hollingsworth TD, Brooker SJ, Anderson RMet al., 2016, Cost-effectiveness of scaling up mass drug administration for the control of soil-transmitted helminths: a comparison of cost function and constant costs analyses, LANCET INFECTIOUS DISEASES, Vol: 16, Pages: 838-846, ISSN: 1473-3099

JOURNAL ARTICLE

Vegvari C, Cauet E, Hadjichrysanthou C, Lawrence E, Weverling G-J, de Wolf F, Anderson RMet al., 2016, Using Clinical Trial Simulators to Analyse the Sources of Variance in Clinical Trials of Novel Therapies for Acute Viral Infections, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Vegvari C, Hadjichrysanthou C, Cauet E, Lawrence E, Cori A, de Wolf F, Anderson RMet al., 2016, How Can Viral Dynamics Models Inform Endpoint Measures in Clinical Trials of Therapies for Acute Viral Infections?, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Anderson RM, 2015, Preface, Publisher: ROYAL SOC

BOOK CHAPTER

Anderson RM, Turner HC, Farrell SH, Yang J, Truscott JEet al., 2015, What is required in terms of mass drug administration to interrupt the transmission of schistosome parasites in regions of endemic infection?, PARASITES & VECTORS, Vol: 8, ISSN: 1756-3305

JOURNAL ARTICLE

Anderson RM, Turner HC, Truscott JE, Hollingsworth TD, Brooker SJet al., 2015, Should the Goal for the Treatment of Soil Transmitted Helminth (STH) Infections Be Changed from Morbidity Control in Children to Community-Wide Transmission Elimination?, PLOS NEGLECTED TROPICAL DISEASES, Vol: 9, ISSN: 1935-2735

JOURNAL ARTICLE

Basanez M-G, Anderson RM, 2015, ADVANCES IN PARASITOLOGY Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part A PREFACE, Publisher: ELSEVIER ACADEMIC PRESS INC, ISBN: 978-0-12-803256-5

BOOK

Basáñez M-G, Anderson RM, 2015, Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part A., Adv Parasitol, Vol: 87, Pages: xiii-xvii

JOURNAL ARTICLE

Brooker SJ, Mwandawiro CS, Halliday KE, Njenga SM, Mcharo C, Gichuki PM, Wasunna B, Kihara JH, Njomo D, Alusala D, Chiguzo A, Turner HC, Teti C, Gwayi-Chore C, Nikolay B, Truscott JE, Hollingsworth TD, Balabanova D, Griffiths UK, Freeman MC, Allen E, Pullan RL, Anderson RMet al., 2015, Interrupting transmission of soil-transmitted helminths: a study protocol for cluster randomised trials evaluating alternative treatment strategies and delivery systems in Kenya, BMJ OPEN, Vol: 5, ISSN: 2044-6055

JOURNAL ARTICLE

Cui H, Lu Y, Khan MZ, Anderson RM, McDaniel L, Wilson HE, Yin TC, Radley JJ, Pieper AA, Lutter Met al., 2015, Behavioral disturbances in estrogen-related receptor alpha-null mice., Cell Rep, Vol: 11, Pages: 344-350

Eating disorders, such as anorexia nervosa and bulimia nervosa, are common and severe mental illnesses of unknown etiology. Recently, we identified a rare missense mutation in the transcription factor estrogen-related receptor alpha (ESRRA) that is associated with the development of eating disorders. However, little is known about ESRRA function in the brain. Here, we report that Esrra is expressed in the mouse brain and demonstrate that Esrra levels are regulated by energy reserves. Esrra-null female mice display a reduced operant response to a high-fat diet, compulsivity/behavioral rigidity, and social deficits. Selective Esrra knockdown in the prefrontal and orbitofrontal cortices of adult female mice recapitulates reduced operant response and increased compulsivity, respectively. These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains.

JOURNAL ARTICLE

Easton AV, Oliveira RG, O'Connell EM, Kepha S, Mwatele C, Brooker SJ, Kihara JH, Mwandawiro C, Njenga SM, Odiere MR, Webster JP, Anderson RM, Nutman TBet al., 2015, MULTI-PARALLEL QPCR PROVIDES INCREASED SENSITIVITY AND DIAGNOSTIC BREADTH ALLOWING FOR IMPROVED EVALUATION OF THE IMPACT OF DEWORMING PROGRAMS FOR SOIL-TRANSMITTED HELMINTHS (STH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 18-18, ISSN: 0002-9637

CONFERENCE PAPER

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