Imperial College London

Professor Sir Roy Anderson FRS, FMedSci

Faculty of MedicineSchool of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3399roy.anderson

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)20 7594 9162

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

451 results found

Gregson S, Zhuwau T, Anderson RM, Chandiwana Set al., 1997, The early socio-demographic impact of the HIV-1 epidemic in rural Zimbabwe., SAfAIDS News, Vol: 5, Pages: 2-5, ISSN: 1029-3256

JOURNAL ARTICLE

Gupta S, Ferguson NM, Anderson RM, 1997, Vaccination and the population structure of antigenically diverse pathogens that exchange genetic material, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 264, Pages: 1435-1443, ISSN: 0962-8452

JOURNAL ARTICLE

Rhodes CJ, Anderson RM, 1997, Epidemic thresholds and vaccination in a lattice model of disease spread, THEORETICAL POPULATION BIOLOGY, Vol: 52, Pages: 101-118, ISSN: 0040-5809

JOURNAL ARTICLE

Rhodes CJ, Folkard SG, Bianco AE, Anderson RMet al., 1997, The kinetics of immunological responses to microfilariae in a murine host: Experimental and mathematical studies, PARASITOLOGY, Vol: 114, Pages: 237-243, ISSN: 0031-1820

JOURNAL ARTICLE

Rhodes CJ, Jensen HJ, Anderson RM, 1997, On the critical behaviour of simple epidemics, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 264, Pages: 1639-1646, ISSN: 0962-8452

JOURNAL ARTICLE

Woolhouse MEJ, Anderson RM, 1997, Understanding the epidemiology of BSE, TRENDS IN MICROBIOLOGY, Vol: 5, Pages: 421-424, ISSN: 0966-842X

JOURNAL ARTICLE

Woolhouse MEJ, Dye C, Etard JF, Smith T, Charlwood JD, Garnett GP, Hagan P, Hii JLK, Ndhlovu PD, Quinnell RJ, Watts CH, Chandiwana SK, Anderson RMet al., 1997, Heterogeneities in the transmission of infectious agents: Implications for the design of control programs, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 94, Pages: 338-342, ISSN: 0027-8424

JOURNAL ARTICLE

Ye XP, Fu YL, Wu ZX, Anderson RM, Agnew Aet al., 1997, The effects of temperature, light and water upon the hatching of the ova of Schistosoma japonicum., Southeast Asian J Trop Med Public Health, Vol: 28, Pages: 575-580, ISSN: 0125-1562

Eggs of Schistosoma japonicum were obtained from infected patients' feces from Yujiang City, China to observe the effects of temperature, light and water on the hatching of eggs. The temperature of water and light played important roles on the hatching of S. japonicum, but the type of water did not. A constant temperature of 28 degrees C and electrical light produced the highest rate of hatching, and reproducible results, whereas a temperature of 4 degrees C or 37 degrees C, and the absence of light inhabited the hatching of eggs. The percentage of eggs hatched during the first 8 hours of 24 hours incubation was 94.90%, so that using the hatching rate of the first 8 hours could approximate the total hatching rate of samples.

JOURNAL ARTICLE

Anderson RM, Donnelly CA, Ferguson NM, Woolhouse MEJ, Watt CJ, Udy HJ, MaWhinney S, Dunstan SP, Southwood TRE, Wilesmith JW, Ryan JBM, Hoinville LJ, Hillerton JE, Austin AR, Wells GAHet al., 1996, Transmission dynamics and epidemiology of BSE in British cattle, NATURE, Vol: 382, Pages: 779-788, ISSN: 0028-0836

JOURNAL ARTICLE

Anderson RM, Garnett GP, 1996, Low-efficacy HIV vaccines: Potential for community-based intervention programmes, LANCET, Vol: 348, Pages: 1010-1013, ISSN: 0140-6736

JOURNAL ARTICLE

Anderson RM, May RM, 1996, The population biology of the interaction between HIV-1 and HIV-2: Coexistence or competitive exclusion?, AIDS, Vol: 10, Pages: 1663-1673, ISSN: 0269-9370

JOURNAL ARTICLE

Anderson RM, Schwartlander B, McCutchan F, Hu Det al., 1996, Implications of genetic variability in HIV for epidemiology and public health, LANCET, Vol: 347, Pages: 1778-1779, ISSN: 0140-6736

JOURNAL ARTICLE

Antia R, Nowak MA, Anderson RM, 1996, Antigenic variation and the within-host dynamics of parasites, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 93, Pages: 985-989, ISSN: 0027-8424

JOURNAL ARTICLE

Austin DJ, Anderson RM, 1996, Immunodominance, competition and evolution in immunological responses to helminth parasite antigens, PARASITOLOGY, Vol: 113, Pages: 157-172, ISSN: 0031-1820

JOURNAL ARTICLE

Austin DJ, Anderson RM, 1996, Immunodominance, competition and evolution in immunological responses to helminth parasite antigens, Parasitology, Vol: 113, Pages: 157-172, ISSN: 0031-1820

The paper describes the development and analysis of a mathematical framework for the study of the within-host population dynamics of the interaction between macroparasites and the human immune system. Simple models of this interaction based on the proliferation of T cell clones specific to parasite antigen, and the impact of clonal expansion on parasite survival, capture the basic features of age-related changes in worm loads within human communities. The model is generalized to multiple epitopes on a single antigen, and reveals competitive exclusion amongst T cells, with a single clone becoming immunodominant in the absence of cross-reactive responses and genetic variation. The introduction of genetic heterogeneity and concomitant variability in the immunogenicity of specific epitopes induces additional complexity into the dynamical interaction. Most importantly, multiple epitope models with antigenic variation suggest that the immunodominant response may not necessarily be targeted at the epitope at which some strains show the greatest immunogenicity. High immunogenicity at a particular epitope can be masked by genetic variability even though many of the variants are more immunogenic at this epitope by comparison with the epitope to which the immunodominant immunological response is directed.

JOURNAL ARTICLE

Basanez MG, Townson H, Williams JR, Frontado H, Villamizar NJ, Anderson RMet al., 1996, Density-dependent processes in the transmission of human onchocerciasis: Relationship between microfilarial intake and mortality of the simuliid vector, PARASITOLOGY, Vol: 113, Pages: 331-355, ISSN: 0031-1820

JOURNAL ARTICLE

Boily MC, Anderson RM, 1996, Human immunodeficiency virus transmission and the role of other sexually transmitted diseases - Measures of association and study design, SEXUALLY TRANSMITTED DISEASES, Vol: 23, Pages: 312-332, ISSN: 0148-5717

JOURNAL ARTICLE

Chan MS, Anderson RM, Medley GF, Bundy DAPet al., 1996, Dynamic aspects of morbidity and acquired immunity in schistosomiasis control, ACTA TROPICA, Vol: 62, Pages: 105-117, ISSN: 0001-706X

JOURNAL ARTICLE

Ferguson NM, Anderson RM, Garnett GP, 1996, Mass vaccination to control chickenpox: The influence of zoster, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 93, Pages: 7231-7235, ISSN: 0027-8424

JOURNAL ARTICLE

Ferguson NM, Nokes DJ, Anderson RM, 1996, Dynamical complexity in age-structured models of the transmission of the measles virus: Epidemiological implications at high levels of vaccine uptake, MATHEMATICAL BIOSCIENCES, Vol: 138, Pages: 101-130, ISSN: 0025-5564

JOURNAL ARTICLE

Garnett GP, Anderson RM, 1996, Sexually transmitted diseases and sexual behavior: Insights from mathematical models, JOURNAL OF INFECTIOUS DISEASES, Vol: 174, Pages: S150-S161, ISSN: 0022-1899

JOURNAL ARTICLE

Garnett GP, Anderson RM, 1996, Antiviral therapy and the transmission dynamics of HIV-1, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 37, Pages: 135-150, ISSN: 0305-7453

JOURNAL ARTICLE

Garnett GP, Hughes JP, Anderson RM, Stoner BP, Aral SO, Whittington WL, Handsfield HH, Holmes KKet al., 1996, Sexual mixing patterns of patients attending sexually transmitted diseases clinics, SEXUALLY TRANSMITTED DISEASES, Vol: 23, Pages: 248-257, ISSN: 0148-5717

JOURNAL ARTICLE

Gregson S, Donnelly C, Parker CG, Anderson RMet al., 1996, Demographic approaches to the estimation of incidence of HIV-1 infection among adults from age-specific prevalence data in stable endemic conditions, AIDS, Vol: 10, Pages: 1689-1697, ISSN: 0269-9370

JOURNAL ARTICLE

Gupta S, Anderson RM, 1996, Transmission dynamics of Plasmodium falciparum: Reply, PARASITOLOGY TODAY, Vol: 12, Pages: 82-83, ISSN: 0169-4758

JOURNAL ARTICLE

Gupta S, Maiden MCJ, Feavers IM, Nee S, May RM, Anderson RMet al., 1996, The maintenance of strain structure in populations of recombining infectious agents, NATURE MEDICINE, Vol: 2, Pages: 437-442, ISSN: 1078-8956

JOURNAL ARTICLE

Herz AVM, Bonhoeffer S, Anderson RM, May RM, Nowak MAet al., 1996, Viral dynamics in vivo: Limitations on estimates of intracellular delay and virus decay, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 93, Pages: 7247-7251, ISSN: 0027-8424

JOURNAL ARTICLE

Hetzel C, Anderson RM, 1996, The within-host cellular dynamics of bloodstage malaria: Theoretical and experimental studies, PARASITOLOGY, Vol: 113, Pages: 25-38, ISSN: 0031-1820

JOURNAL ARTICLE

Nowak MA, Anderson RM, Boerlijst MC, Bonhoeffer S, May RM, McMichael AJet al., 1996, HIV-1 evolution and disease progression, SCIENCE, Vol: 274, Pages: 1008-1010, ISSN: 0036-8075

JOURNAL ARTICLE

Rhodes CJ, Anderson RM, 1996, Dynamics in a lattice epidemic model, PHYSICS LETTERS A, Vol: 210, Pages: 183-188, ISSN: 0375-9601

JOURNAL ARTICLE

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