Imperial College London

Professor Sir Roy Anderson FRS, FMedSci

Faculty of MedicineSchool of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
//

Contact

 

+44 (0)20 7594 3399roy.anderson

 
 
//

Assistant

 

Mrs Clare Mylchreest +44 (0)20 7594 9162

 
//

Location

 

LG35Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Publication Type
Year
to

488 results found

Truscott JE, Dunn JC, Papaiakovou M, Schaer F, Werkman M, Littlewood DTJ, Walson JL, Anderson RMet al., 2019, Calculating the prevalence of soil-transmitted helminth infection through pooling of stool samples: Choosing and optimizing the pooling strategy., PLoS Negl Trop Dis, Vol: 13

Prevalence is a common epidemiological measure for assessing soil-transmitted helminth burden and forms the basis for much public-health decision-making. Standard diagnostic techniques are based on egg detection in stool samples through microscopy and these techniques are known to have poor sensitivity for individuals with low infection intensity, leading to poor sensitivity in low prevalence populations. PCR diagnostic techniques offer very high sensitivities even at low prevalence, but at a greater cost for each diagnostic test in terms of equipment needed and technician time and training. Pooling of samples can allow prevalence to be estimated while minimizing the number of tests performed. We develop a model of the relative cost of pooling to estimate prevalence, compared to the direct approach of testing all samples individually. Analysis shows how expected relative cost depends on both the underlying prevalence in the population and the size of the pools constructed. A critical prevalence level (approx. 31%) above which pooling is never cost effective, independent of pool size. When no prevalence information is available, there is no basis on which to choose between pooling and testing all samples individually. We recast our model of relative cost in a Bayesian framework in order to investigate how prior information about prevalence in a given population can be used to inform the decision to choose either pooling or full testing. Results suggest that if prevalence is below 10%, a relatively small exploratory prevalence survey (10-15 samples) can be sufficient to give a high degree of certainty that pooling may be relatively cost effective.

JOURNAL ARTICLE

Anderson RM, Hadjichrysanthou C, Evans S, McRae-McKee K, Wong MMet al., 2019, Unsuccessful trials of therapies for Alzheimer's disease - Authors' reply., Lancet, Vol: 393, Pages: 29-30

JOURNAL ARTICLE

Anderson RM, Hadjichrysanthou C, Evans S, McRae-McKee K, Wong MMet al., 2019, Unsuccessful trials of therapies for Alzheimer's disease Reply, LANCET, Vol: 393, Pages: 29-30, ISSN: 0140-6736

JOURNAL ARTICLE

Toor J, Turner HC, Truscott JE, Werkman M, Phillips AE, Alsallaq R, Medley GF, King CH, Anderson RMet al., 2018, The design of schistosomiasis monitoring and evaluation programmes: The importance of collecting adult data to inform treatment strategies for Schistosoma mansoni, PLOS NEGLECTED TROPICAL DISEASES, Vol: 12, ISSN: 1935-2735

JOURNAL ARTICLE

Werkman M, Toor J, Vegvari C, Wright JE, Truscott JE, Asbjornsdottir KH, Means AR, Walson JL, Anderson RMet al., 2018, Defining stopping criteria for ending randomized clinical trials that investigate the interruption of transmission of soil-transmitted helminths employing mass drug administration, PLOS NEGLECTED TROPICAL DISEASES, Vol: 12, ISSN: 1935-2735

JOURNAL ARTICLE

Ower AK, Hadjichrysanthou C, Gras L, Goudsmit J, Anderson RM, de Wolf Fet al., 2018, Temporal association patterns and dynamics of amyloid-beta and tau in Alzheimer's disease, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 33, Pages: 657-666, ISSN: 0393-2990

JOURNAL ARTICLE

Toor J, Alsallaq R, Truscott JE, Turner HC, Werkman M, Gurarie D, King CH, Anderson RMet al., 2018, Are We on Our Way to Achieving the 2020 Goals for Schistosomiasis Morbidity Control Using Current World Health Organization Guidelines?, CLINICAL INFECTIOUS DISEASES, Vol: 66, Pages: S245-S252, ISSN: 1058-4838

JOURNAL ARTICLE

Farrell SH, Coffeng LE, Truscott JE, Werkman M, Toor J, de Vlas SJ, Anderson RMet al., 2018, Investigating the Effectiveness of Current and Modified World Health Organization Guidelines for the Control of Soil-Transmitted Helminth Infections, CLINICAL INFECTIOUS DISEASES, Vol: 66, Pages: S253-S259, ISSN: 1058-4838

JOURNAL ARTICLE

Turner HC, Toor J, Hollingsworth TD, Anderson RMet al., 2018, Economic Evaluations of Mass Drug Administration: The Importance of Economies of Scale and Scope, CLINICAL INFECTIOUS DISEASES, Vol: 66, Pages: 1298-1303, ISSN: 1058-4838

JOURNAL ARTICLE

Savioli L, Albonico M, Daumerie D, Lo NC, Stothard JR, Asaolu S, Tchuente LAT, Anderson RMet al., 2018, Review of the 2017 WHO Guideline: Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups. An opportunity lost in translation, PLOS NEGLECTED TROPICAL DISEASES, Vol: 12, ISSN: 1935-2735

JOURNAL ARTICLE

Farrell SH, Anderson RM, 2018, Helminth lifespan interacts with noncompliance in reducing the effectiveness of anthelmintic treatment, PARASITES & VECTORS, Vol: 11, ISSN: 1756-3305

JOURNAL ARTICLE

Wright JE, Werkman M, Dunn JC, Anderson RMet al., 2018, Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review, PARASITES & VECTORS, Vol: 11, ISSN: 1756-3305

JOURNAL ARTICLE

Hadjichrysanthou C, Ower AK, de Wolf F, Anderson RMet al., 2018, The development of a stochastic mathematical model of Alzheimer's disease to help improve the design of clinical trials of potential treatments, PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

Davis EL, Danon L, Prada JM, Gunawardena SA, Truscott JE, Vlaminck J, Anderson RM, Levecke B, Morgan ER, Hollingsworth TDet al., 2018, Seasonally timed treatment programs for Ascaris lumbricoides to increase impact-An investigation using mathematical models, PLOS NEGLECTED TROPICAL DISEASES, Vol: 12, ISSN: 1935-2735

JOURNAL ARTICLE

Asbjornsdottir KH, Ajjampur SSR, Anderson RM, Bailey R, Gardiner I, Halliday KE, Ibikounle M, Kalua K, Kang G, Littlewood DTJ, Luty AJF, Means AR, Oswald W, Pullan RL, Sarkar R, Schar F, Szpiro A, Truscott JE, Werkman M, Yard E, Walson JLet al., 2018, Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol, PLOS NEGLECTED TROPICAL DISEASES, Vol: 12, ISSN: 1935-2735

JOURNAL ARTICLE

Werkman M, Wright JE, Truscott JE, Easton AV, Oliveira RG, Toor J, Ower A, Asbjornsdottir KHA, Means AR, Farrell SH, Walson JL, Anderson RMet al., 2018, Testing for soil-transmitted helminth transmission elimination: Analysing the impact of the sensitivity of different diagnostic tools, PLOS NEGLECTED TROPICAL DISEASES, Vol: 12, ISSN: 1935-2735

JOURNAL ARTICLE

Hadjichrysanthou C, McRae-McKee K, Evans S, de Wolf F, Anderson RMet al., 2018, Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies, JOURNAL OF ALZHEIMERS DISEASE, Vol: 66, Pages: 587-600, ISSN: 1387-2877

JOURNAL ARTICLE

Anderson RM, Hadjichrysanthou C, Evans S, Wong MMet al., 2017, Why do so many clinical trials of therapies for Alzheimer's disease fail?, LANCET, Vol: 390, Pages: 2327-2329, ISSN: 0140-6736

JOURNAL ARTICLE

Sarkar R, Truscott JE, Veluswamy V, Roy S, Rose A, Srinivasan R, Mohan VR, Balraj V, Muliyil J, Kang G, Anderson RMet al., 2017, UNDERSTANDING THE EPIDEMIOLOGY OF HOOKWORM INFECTION IN A LOW-TRANSMISSION SETTING IN SOUTHERN INDIA: ANALYSIS OF DATA FROM A CLUSTER-RANDOMIZED MASS DEWORMING TRIAL, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH)

POSTER

Stylianou A, Siddiqui AA, Anderson RM, 2017, MODELLING THE EFFECT OF A POTENTIAL VACCINE APPLICATION ON THE SCHISTOSOME PARASITE DYNAMICS, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH)

POSTER

Oliveira RG, Easton AV, Kihara JH, Mwatele C, Njenga SM, Mwandawiro CS, Lamberton PH, Brooker SJ, Anderson RMet al., 2017, REPEATED ROUNDS OF MASS DEWORMING ADMINISTRATION STILL LEAVE HOUSEHOLD CLUSTERING OF SOIL-TRANSMITTED HELMINTH INFECTIONS, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH)

POSTER

Dunn JC, Bettis AA, Wyine NY, Lwin AMM, Maung NS, Anderson RMet al., 2017, RISK FACTORS ASSOCIATED WITH PREDISPOSITION TO SOIL-TRANSMITTED HELMINTH INFECTION IN SOUTHERN MYANMAR, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH)

POSTER

Levecke B, Ghebretinsae AH, Anderson RM, Berkvens D, Vlaminck J, Devleesschauwer B, Speybroeck N, Vercruysse J, Van Aelst Set al., 2017, GUIDANCE IN DESIGNING SURVEYS FOR MONITORING SURVEYS FOR MONITORING THE PROGRESS OF SCHOOL-BASED DEWORMING PROGRAMS TO CONTROL SOIL-TRANSMITTED HELMINTHIASIS, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH)

POSTER

Dunn JC, Bettis AA, Wyine NY, Lwin AMM, Lwin ST, Su KK, Sein MM, Tun A, Maung NS, Anderson RMet al., 2017, A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Srinivasa Rao ASR, Anderson RM, 2017, Helminth Dynamics: Mean Number of Worms, Reproductive Rates, Handbook of Statistics, Publisher: North-Holland Publ Co, Pages: 397-404

© 2017 Elsevier B.V. Understanding the mean number of worms and burden of soil transmitted helminth infections are considered as important parameters in formulating treatment strategies to eliminate worms among children who are effected by helminth infections (Anderson et al., 2015). We derive mean number of worms in a newly helminth infected population before secondary infections are started (population is closed). Further we bring analytical solutions. We also theoretically demonstrate computing net reproductive rates within and outside a human host.

BOOK CHAPTER

Truscott JE, Werkman M, Wright JE, Farrell SH, Sarkar R, Asbjornsdottir K, Anderson RMet al., 2017, Identifying optimal threshold statistics for elimination of hookworm using a stochastic simulation model, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Farrell SH, Truscott JE, Anderson RM, 2017, The importance of patient compliance in repeated rounds of mass drug administration (MDA) for the elimination of intestinal helminth transmission, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Turner HC, Bettis AA, Dunn JC, Whitton JM, Hollingsworth D, Fleming FM, Anderson RMet al., 2017, Economic Considerations for Moving beyond the Kato-Katz Technique for Diagnosing Intestinal Parasites As We Move Towards Elimination, TRENDS IN PARASITOLOGY, Vol: 33, Pages: 435-443, ISSN: 1471-4922

JOURNAL ARTICLE

Easton AV, Oliveira RG, Walker M, O'Connell EM, Njenga SM, Mwandawiro CS, Webster JP, Nutman TB, Anderson RMet al., 2017, Sources of variability in the measurement of Ascaris lumbricoides infection intensity by Kato-Katz and qPCR, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00152009&limit=30&person=true