Publications
645 results found
Turner HC, Truscott JE, Hollingsworth TD, et al., 2015, Cost and cost-effectiveness of soil-transmitted helminth treatment programmes: systematic review and research needs., Parasites & Vectors, Vol: 8, ISSN: 1756-3305
BACKGROUND: In this time of rapidly expanding mass drug administration (MDA) coverage and the new commitments for soil-transmitted helminth (STH) control, it is essential that resources are allocated in an efficient manner to have the greatest impact. However, many questions remain regarding how best to deliver STH treatment programmes; these include which age-groups should be targeted and how often. To perform further analyses to investigate what the most cost-effective control strategies are in different settings, accurate cost data for targeting different age groups at different treatment frequencies (in a range of settings) are essential. METHODS: Using the electronic databases PubMed, MEDLINE, and ISI Web of Knowledge, we perform a systematic review of costing studies and cost-effectiveness evaluations for potential STH treatment strategies. We use this review to highlight research gaps and outline the key future research needs. RESULTS: We identified 29 studies reporting costs of STH treatment and 17 studies that investigated its cost-effectiveness. The majority of these pertained to programmes only targeting school-aged children (SAC), with relatively few studies investigating alternative preventive chemotherapy (PCT) treatment strategies. The methods of cost data collection, analysis and reporting were highly variable among the different studies. Only four of the costing studies were found to have high applicability for use in forthcoming economic evaluations. There are also very few studies quantifying the costs of increasing the treatment frequency. CONCLUSIONS: The absence of cost data and inconsistencies in the collection and analysis methods constitutes a major research gap for STH control. Detailed and accurate costs of targeting different age groups or increasing treatment frequency will be essential to formulate cost-effective public health policy. Defining the most cost-effective control strategies in different settings is of high significance durin
Anderson RM, 2015, Preface, Philosophical Transactions of the Royal Society B: Biological Sciences, Vol: 370, Pages: 20140305-20140305, ISSN: 0962-8436
Cui H, Lu Y, Khan MZ, et al., 2015, Behavioral Disturbances in Estrogen-Related Receptor alpha-Null Mice, CELL REPORTS, Vol: 11, Pages: 344-350, ISSN: 2211-1247
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- Citations: 20
Heesterbeek H, Anderson RM, Andreasen V, et al., 2015, Modeling infectious disease dynamics in the complex landscape of global health, SCIENCE, Vol: 347, Pages: 1216-U29, ISSN: 0036-8075
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- Citations: 366
Basáñez M-G, Anderson RM, 2015, Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part A., Adv Parasitol, Vol: 87, Pages: xiii-xvii
Levecke B, Anderson RM, Berkvens D, et al., 2015, Mathematical Inference on Helminth Egg Counts in Stool and Its Applications in Mass Drug Administration Programmes to Control Soil-Transmitted Helminthiasis in Public Health, MATHEMATICAL MODELS FOR NEGLECTED TROPICAL DISEASES: ESSENTIAL TOOLS FOR CONTROL AND ELIMINATION, PT A, Vol: 87, Pages: 193-247, ISSN: 0065-308X
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- Citations: 34
Basanez M-G, Anderson RM, 2015, ADVANCES IN PARASITOLOGY Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part A PREFACE, Publisher: ELSEVIER ACADEMIC PRESS INC, ISBN: 978-0-12-803256-5
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- Citations: 3
Truscott J, Hollingsworth TD, Anderson R, 2014, Modeling the Interruption of the Transmission of Soil-Transmitted Helminths by Repeated Mass Chemotherapy of School-Age Children, PLOS NEGLECTED TROPICAL DISEASES, Vol: 8, ISSN: 1935-2735
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- Citations: 32
Anderson R, Truscott J, Hollingsworth TD, 2014, The coverage and frequency of mass drug administration required to eliminate persistent transmission of soil-transmitted helminths, Philosophical Transactions of the Royal Society B: Biological Sciences, Vol: 369, ISSN: 1471-2970
A combination of methods, including mathematical model construction, demographic plus epidemiological data analysis and parameter estimation, are used to examine whether mass drug administration (MDA) alone can eliminate the transmission of soil-transmitted helminths (STHs). Numerical analyses suggest that in all but low transmission settings (as defined by the magnitude of the basic reproductive number, R0), the treatment of pre-school-aged children (pre-SAC) and school-aged children (SAC) is unlikely to drive transmission to a level where the parasites cannot persist. High levels of coverage (defined as the fraction of an age group effectively treated) are required in pre-SAC, SAC and adults, if MDA is to drive the parasite below the breakpoint under which transmission is eliminated. Long-term solutions to controlling helminth infections lie in concomitantly improving the quality of the water supply, sanitation and hygiene (WASH). MDA, however, is a very cost-effective tool in long-term control given that most drugs are donated free by the pharmaceutical industry for poor regions of the world. WASH interventions, by lowering the basic reproductive number, can facilitate the ability of MDA to interrupt transmission.
Truscott JE, Hollingsworth TD, Brooker SJ, et al., 2014, Can chemotherapy alone eliminate the transmission of soil transmitted helminths?, PARASITES & VECTORS, Vol: 7, ISSN: 1756-3305
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- Citations: 99
Hollingsworth TD, Truscott JE, Anderson RM, 2013, Chapter 9 - Transmission Dynamics of Ascaris lumbricoides – Theory and Observation, Ascaris: the Neglected Parasite, Pages: 231-262, ISBN: 978-0-12-396978-1
Anderson RM, Truscott JE, Pullan R, et al., 2013, How Effective Is School-Based Deworming for the Community-Wide Control of Soil-Transmitted Helminths?, PLOS NTDS, Vol: 2
Boily MC, Brisson M, Mâsse B, et al., 2012, The role of mathematical models in vaccine development and public health decision making, Vaccinology: Principles and Practice, Pages: 480-508, ISBN: 9781405185745
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- Citations: 5
Anderson RM, Hollingsworth TD, Truscott J, et al., 2012, Optimisation of mass chemotherapy to control soil-transmitted helminth infection (vol 379, pg 289, 2012), LANCET, Vol: 379, Pages: 1102-1102, ISSN: 0140-6736
Cauchemez S, Boelle PY, Donnelly CA, et al., 2012, Real-time estimates in early detection of SARS, Emerging Infectious Diseases, Vol: 12, Pages: 110-113, ISSN: 1080-6040
We propose a Bayesian statistical framework for estimating the reproduction number R early in an epidemic. This method allows for the yet-unrecorded secondary cases if the estimate is obtained before the epidemic has ended. We applied our approach to the severe acute respiratory syndrome (SARS) epidemic that started in February 2003 in Hong Kong. Temporal patterns of R estimated after 5, 10, and 20 days were similar. Ninety-five percent credible intervals narrowed when more data were available but stabilized after 10 days. Using simulation studies of SARS-like outbreaks, we have shown that the method may be used for early monitoring of the effect of control measures.
Anderson R, Hollingsworth TD, Truscott J, et al., 2012, Optimisation of mass chemotherapy to control soil-transmitted helminth infection, LANCET, Vol: 379, Pages: 289-290, ISSN: 0140-6736
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- Citations: 40
Anderson RM, Hollingsworth TD, Truscott J, et al., 2012, Optimisation of mass chemotherapy to control soil-transmitted helminth infection., Lancet, Pages: 289-290
Anderson RM, Hollingsworth TD, Truscott J, et al., 2012, Erratum: Optimisation of mass chemotherapy to control soil-transmitted helminth infection (Lancet (2012) 379 (289-90)), The Lancet, Vol: 379, ISSN: 0140-6736
Hollingsworth TD, Klinkenberg D, Heesterbeek H, et al., 2011, Mitigation Strategies for Pandemic Influenza A: Balancing Conflicting Policy Objectives, Plos Computational Biology, Vol: 7, ISSN: 1553-7358
Mitigation of a severe influenza pandemic can be achieved using a range of interventions to reduce transmission. Interventions can reduce the impact of an outbreak and buy time until vaccines are developed, but they may have high social and economic costs. The non-linear effect on the epidemic dynamics means that suitable strategies crucially depend on the precise aim of the intervention. National pandemic influenza plans rarely contain clear statements of policy objectives or prioritization of potentially conflicting aims, such as minimizing mortality (depending on the severity of a pandemic) or peak prevalence or limiting the socio-economic burden of contact-reducing interventions. We use epidemiological models of influenza A to investigate how contact-reducing interventions and availability of antiviral drugs or pre-pandemic vaccines contribute to achieving particular policy objectives. Our analyses show that the ideal strategy depends on the aim of an intervention and that the achievement of one policy objective may preclude success with others, e.g., constraining peak demand for public health resources may lengthen the duration of the epidemic and hence its economic and social impact. Constraining total case numbers can be achieved by a range of strategies, whereas strategies which additionally constrain peak demand for services require a more sophisticated intervention. If, for example, there are multiple objectives which must be achieved prior to the availability of a pandemic vaccine (i.e., a time-limited intervention), our analysis shows that interventions should be implemented several weeks into the epidemic, not at the very start. This observation is shown to be robust across a range of constraints and for uncertainty in estimates of both R0 and the timing of vaccine availability. These analyses highlight the need for more precise statements of policy objectives and their assumed consequences when planning and implementing strategies to mitigate the impac
Kounaves SP, Stroble ST, Anderson RM, et al., 2010, Discovery of Natural Perchlorate in the Antarctic Dry Valleys and Its Global Implications, ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol: 44, Pages: 2360-2364, ISSN: 0013-936X
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- Citations: 143
Anderson RM, 2009, How well are we managing the influenza A/H1N1 pandemic in the UK?, BMJ-BRITISH MEDICAL JOURNAL, Vol: 339, ISSN: 1756-1833
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- Citations: 17
Anderson RM, Hollingsworth TD, Nokes DJ, 2009, Mathematical models of transmission and control, Oxford Textbook of Public Health, Editors: Detels, Beaglehole, Lansang, Gulliford, Oxford, UK, Publisher: Oxford University Press, ISBN: 9780199218707
Walker M, Hall A, Anderson RM, et al., 2009, Density-dependent effects on the weight of female Ascaris lumbricoides infections of humans and its impact on patterns of egg production., Parasit Vectors, Vol: 2, Pages: 1-18, ISSN: 1756-3305
ABSTRACT:
Walker M, Hall A, Anderson RM, et al., 2008, FACTORS AFFECTING THE FECUNDITY OF <i>ASCARIS LUMBRICOIDES</i> AND THEIR IMPACT ON PATTERNS OF DENSITY DEPENDENCE, 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene, Publisher: AMER SOC TROP MED & HYGIENE, Pages: 337-337, ISSN: 0002-9637
Walker M, Basanez M-G, Hall A, et al., 2008, TEMPORAL DYNAMICS OF THE SEX RATIO OF <i>ASCARIS LUMBRICOIDES</i> AND ITS IMPLICATIONS FOR TRANSMISSION, 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene, Publisher: AMER SOC TROP MED & HYGIENE, Pages: 337-337, ISSN: 0002-9637
Rhodes CJ, Anderson RM, 2008, Contact rate calculation for a basic epidemic model, MATHEMATICAL BIOSCIENCES, Vol: 216, Pages: 56-62, ISSN: 0025-5564
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- Citations: 24
Hollingsworth TD, Anderson RM, Fraser C, 2008, HIV-1 transmission, by stage of infection, JOURNAL OF INFECTIOUS DISEASES, Vol: 198, Pages: 687-693, ISSN: 0022-1899
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- Citations: 476
Boily M-C, Abu-Raddad L, Desai K, et al., 2008, Measuring the public-health impact of candidate HIV vaccines as part of the licensing process, LANCET INFECTIOUS DISEASES, Vol: 8, Pages: 200-207, ISSN: 1473-3099
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- Citations: 16
Leung GM, Hedley AJ, Lam TH, et al., 2008, Transmission dynamics and control of the viral aetiological agent of severe acute respiratory syndrome (SARS)., Severe Acute Respiratory Syndrome, Editors: Peiris, Anderson, Osterhaus, Stohr, Yuen, Oxford, United Kingdom, Publisher: Blackwell Publishing LTD
Boily M-C, Lowndes CM, Vickerman P, et al., 2007, Evaluating large-scale HIV prevention interventions: study design for an integrated mathematical modelling approach, SEXUALLY TRANSMITTED INFECTIONS, Vol: 83, Pages: 582-589, ISSN: 1368-4973
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- Citations: 43
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