Imperial College London
Alternate

Professor Sir Roy Anderson FRS, FMedSci

Faculty of Medicine, School of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

roy.anderson Website

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)7766 331 301

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pullan:2019:10.1016/S0140-6736(18)32591-1,
author = {Pullan, RL and Halliday, KE and Oswald, WE and Mcharo, C and Beaumont, E and Kepha, S and Witek-McManus, S and Gichuki, PM and Allen, E and Drake, T and Pitt, C and Matendechero, SH and Gwayi-Chore, M-C and Anderson, RM and Njenga, SM and Brooker, SJ and Mwandawiro, CS},
doi = {10.1016/S0140-6736(18)32591-1},
journal = {The Lancet},
pages = {2039--2050},
title = {Effects, equity, and cost of school-based and community-wide treatment strategies for soil-transmitted helminths in Kenya: a cluster-randomised controlled trial},
url = {http://dx.doi.org/10.1016/S0140-6736(18)32591-1},
volume = {393},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background School-based deworming programmes can reduce morbidity attributable to soil-transmitted helminthsin children but do not interrupt transmission in the wider community. We assessed the effects of alternative masstreatment strategies on community soil-transmitted helminth infection.Methods In this cluster-randomised controlled trial, 120 community units (clusters) serving 150 000 households inKenya were randomly assigned (1:1:1) to receive albendazole through annual school-based treatment targeting2–14 year olds or annual or biannual community-wide treatment targeting all ages. The primary outcome wascommunity hookworm prevalence, assessed at 12 and 24 months through repeat cross-sectional surveys. Secondaryoutcomes were Ascaris lumbricoides and Trichuris trichiura prevalence, infection intensity of each soil-transmittedhelminth species, and treatment coverage and costs. Analysis was by intention to treat. This trial is registered withClinicalTrials.gov, number NCT02397772.Findings After 24 months, prevalence of hookworm changed from 18·6% (95% CI 13·9–23·2) to 13·8% (10·5–17·0)in the annual school-based treatment group, 17·9% (13·7–22·1) to 8·0% (6·0–10·1) in the annual community-widetreatment group, and 20·6% (15·8–25·5) to 6·2% (4·9–7·5) in the biannual community-wide treatment group.Relative to annual school-based treatment, the risk ratio for annual community-wide treatment was 0·59 (95% CI0·42–0·83; p<0·001) and for biannual community-wide treatment was 0·46 (0·33–0·63; p<0·001). More modestreductions in risk were observed after 12 months. Risk ratios were similar across demographic and socioeconomicsubgroups after 24 months. No adverse events related to albendazole were reported.Interpretation Community-wide treat
AU  - Pullan,RL
AU  - Halliday,KE
AU  - Oswald,WE
AU  - Mcharo,C
AU  - Beaumont,E
AU  - Kepha,S
AU  - Witek-McManus,S
AU  - Gichuki,PM
AU  - Allen,E
AU  - Drake,T
AU  - Pitt,C
AU  - Matendechero,SH
AU  - Gwayi-Chore,M-C
AU  - Anderson,RM
AU  - Njenga,SM
AU  - Brooker,SJ
AU  - Mwandawiro,CS
DO  - 10.1016/S0140-6736(18)32591-1
EP  - 2050
PY  - 2019///
SN  - 0140-6736
SP  - 2039
TI  - Effects, equity, and cost of school-based and community-wide treatment strategies for soil-transmitted helminths in Kenya: a cluster-randomised controlled trial
T2  - The Lancet
UR  - http://dx.doi.org/10.1016/S0140-6736(18)32591-1
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000468112000027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/74920
VL  - 393
ER  -
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