Imperial College London
Alternate

Professor Sir Roy Anderson FRS, FMedSci

Faculty of Medicine, School of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

roy.anderson Website

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)7766 331 301

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Halliday:2019:10.1371/journal.pntd.0007427,
author = {Halliday, KE and Oswald, WE and Mcharo, C and Beaumont, E and Gichuki, PM and Kepha, S and Witek-McManus, SS and Matendechero, SH and El-Busaidy, H and Muendo, R and Chiguzo, AN and Cano, J and Karanja, MW and Musyoka, LW and Safari, TK and Mutisya, LN and Muye, IJ and Sidigu, MA and Anderson, RM and Allen, E and Brooker, SJ and Mwandawiro, CS and Njenga, SM and Pullan, RL},
doi = {10.1371/journal.pntd.0007427},
journal = {PLoS Neglected Tropical Diseases},
pages = {1--22},
title = {Community-level epidemiology of soil-transmitted helminths in the context of school-based deworming: Baseline results of a cluster randomised trial on the coast of Kenya},
url = {http://dx.doi.org/10.1371/journal.pntd.0007427},
volume = {13},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Most epidemiological studies of soil-transmitted helminth (STH) infections focus on school-going children. The majority of large-scale cross-sectional and longitudinal community-based studies have been conducted prior to the implementation of wide-scale mass drug administration (MDA). This study investigates age-related patterns in prevalence and intensity of STH infection, and associated risk factors, in a region of south coastal Kenya that had previously received three consecutive years of school-based deworming (2012–14) and four rounds of community-based MDA for lymphatic filariasis between 2003 and 2014. Between March and May 2015, a cross-sectional survey was conducted in 120 community clusters as a baseline for a cluster randomised trial. Individuals aged two years and above were randomly selected during household surveys and requested to provide stool samples, which were assessed for presence and intensity of STH using the duplicate Kato-Katz thick smear method. Species-specific predictors of presence and intensity were investigated through multilevel logistic regression and zero-inflated negative binomial regression models. Of the 19,684 individuals who provided a stool sample, 21.5% were infected with at least one STH. Hookworm was the predominant species, with an overall prevalence of 19.1%; Trichuris trichiura prevalence was 3.6% and Ascaris lumbricoides was negligible (0.4% prevalence). The vast majority were light intensity infections. Prevalence and intensity of hookworm infection were significantly higher in adults and males, and were associated with environmental conditions, low socio-economic status, household flooring, individual and household water, sanitation and hygiene (WASH) characteristics and behaviours, previous treatment, lack of shoe-wearing and not attending school. In contrast, T. trichiura was more commonly found in school-aged boys and those living in communities close to the coast, with reduced infection in the least poor indi
AU  - Halliday,KE
AU  - Oswald,WE
AU  - Mcharo,C
AU  - Beaumont,E
AU  - Gichuki,PM
AU  - Kepha,S
AU  - Witek-McManus,SS
AU  - Matendechero,SH
AU  - El-Busaidy,H
AU  - Muendo,R
AU  - Chiguzo,AN
AU  - Cano,J
AU  - Karanja,MW
AU  - Musyoka,LW
AU  - Safari,TK
AU  - Mutisya,LN
AU  - Muye,IJ
AU  - Sidigu,MA
AU  - Anderson,RM
AU  - Allen,E
AU  - Brooker,SJ
AU  - Mwandawiro,CS
AU  - Njenga,SM
AU  - Pullan,RL
DO  - 10.1371/journal.pntd.0007427
EP  - 22
PY  - 2019///
SN  - 1935-2727
SP  - 1
TI  - Community-level epidemiology of soil-transmitted helminths in the context of school-based deworming: Baseline results of a cluster randomised trial on the coast of Kenya
T2  - PLoS Neglected Tropical Diseases
UR  - http://dx.doi.org/10.1371/journal.pntd.0007427
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000490919400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007427
UR  - http://hdl.handle.net/10044/1/75155
VL  - 13
ER  -
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