Imperial College London
Alternate

Professor Sir Roy Anderson FRS, FMedSci

Faculty of Medicine, School of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

roy.anderson Website

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)7766 331 301

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Werkman:2020:10.1186/s13071-020-04149-4,
author = {Werkman, M and Wright, JE and Truscott, JE and Oswald, WE and Halliday, KE and Papaiakovou, M and Farrell, SH and Pullan, RL and Anderson, RM},
doi = {10.1186/s13071-020-04149-4},
journal = {Parasites and Vectors},
title = {The impact of community-wide, mass drug administration on aggregation of soil-transmitted helminth infection in human host populations},
url = {http://dx.doi.org/10.1186/s13071-020-04149-4},
volume = {13},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundSoil-transmitted helminths (STH) are intestinal parasites estimated to infect over 1.5 billion people. Current treatment programmes are aimed at morbidity control through school-based deworming programmes (targeting school-aged children, SAC) and treating women of reproductive age (WRA), as these two groups are believed to record the highest morbidity. More recently, however, the potential for interrupting transmission by treating entire communities has been receiving greater emphasis and the feasibility of such programmes are now under investigation in randomised clinical trials through the Bill & Melinda Gates Foundation funded DeWorm3 studies. Helminth parasites are known to be highly aggregated within human populations, with a small minority of individuals harbouring most worms. Empirical evidence from the TUMIKIA project in Kenya suggests that aggregation may increase significantly after anthelminthic treatment.MethodsA stochastic, age-structured, individual-based simulation model of parasite transmission is employed to better understand the factors that might induce this pattern. A simple probabilistic model based on compounded negative binomial distributions caused by age-dependencies in both treatment coverage and exposure to infection is also employed to further this understanding.ResultsBoth approaches confirm helminth aggregation is likely to increase post-mass drug administration as measured by a decrease in the value of the negative binomial aggregation parameter, k. Simple analytical models of distribution compounding describe the observed patterns well.ConclusionsThe helminth aggregation that was observed in the field was replicated with our stochastic individual-based model. Further work is required to generalise the probabilistic model to take account of the respective sensitivities of different diagnostics on the presence or absence of infection.
AU  - Werkman,M
AU  - Wright,JE
AU  - Truscott,JE
AU  - Oswald,WE
AU  - Halliday,KE
AU  - Papaiakovou,M
AU  - Farrell,SH
AU  - Pullan,RL
AU  - Anderson,RM
DO  - 10.1186/s13071-020-04149-4
PY  - 2020///
SN  - 1756-3305
TI  - The impact of community-wide, mass drug administration on aggregation of soil-transmitted helminth infection in human host populations
T2  - Parasites and Vectors
UR  - http://dx.doi.org/10.1186/s13071-020-04149-4
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000540834500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/80710
VL  - 13
ER  -
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