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@article{Kepha:2017:10.1186/s40249-017-0244-z,
author = {Kepha, S and Mwandawiro, CS and Anderson, RM and Pullan, RL and Nuwaha, F and Cano, J and Njenga, SM and Odiere, MR and Allen, E and Brooker, SJ and Nikolay, B},
doi = {10.1186/s40249-017-0244-z},
journal = {Infectious Diseases of Poverty},
title = {Impact of single annual treatment and four-monthly treatment for hookworm and Ascaris lumbricoides, and factors associated with residual infection among Kenyan school children},
url = {http://dx.doi.org/10.1186/s40249-017-0244-z},
volume = {6},
year = {2017}
}

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TY  - JOUR
AB  - BackgroundSchool-based deworming is widely implemented in various countries to reduce the burden of soil-transmitted helminths (STHs), however, the frequency of drug administration varies in different settings. In this study, we compared the impact of a single annual treatment and 4-monthly treatment over a follow-up among Kenyan school children, and investigated the factors associated with residual infection.MethodsWe performed a secondary analysis of data from a randomized trial investigating whether deworming for STHs alters risk of acquiring malaria. Children received either a single treatment or 4-monthly albendazole treatments were followed longitudinally from February 2014 to October 2014. The relative impact of treatment and factors associated with residual infections were investigated using mixed-effects regression models. Predisposition to infection was assessed based on Spearman’s rank and Kendall’s Tau correlation coefficients.ResultsIn the 4-monthly treatment group, the proportion of children infected with hookworm decreased from 59.9 to 5.7%, while Ascaris lumbricoides infections dropped from 55.7 to 6.2%. In the single treatment group, hookworm infections decreased over the same time period from 58.7 to 18.3% (12.6% absolute difference in reduction, 95% CI: 8.9–16.3%), and A. lumbricoides from 56.7 to 23.3% (17.1% absolute difference in reduction, 95% CI: 13.1–21.1%). There was strong evidence for predisposition to both STH types. Residual hookworm infection among children on 4-monthly treatment were associated with male sex and baseline nutritional status, whereas A. lumbricoides infection was associated with individual and school-level infection at baseline, latrine cleanliness at schools.ConclusionsThis study found that 4-monthly treatment w more effective than single annual treatment. Repeated treatments led to dramatic reductions in the intensities of STHs, but did not completely clear infections among school children in K
AU  - Kepha,S
AU  - Mwandawiro,CS
AU  - Anderson,RM
AU  - Pullan,RL
AU  - Nuwaha,F
AU  - Cano,J
AU  - Njenga,SM
AU  - Odiere,MR
AU  - Allen,E
AU  - Brooker,SJ
AU  - Nikolay,B
DO  - 10.1186/s40249-017-0244-z
PY  - 2017///
SN  - 2049-9957
TI  - Impact of single annual treatment and four-monthly treatment for hookworm and Ascaris lumbricoides, and factors associated with residual infection among Kenyan school children
T2  - Infectious Diseases of Poverty
UR  - http://dx.doi.org/10.1186/s40249-017-0244-z
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394303100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/65677
VL  - 6
ER  -

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