Imperial College London
Alternate

Professor Sir Roy Anderson FRS, FMedSci

Faculty of Medicine, School of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

roy.anderson Website

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)7766 331 301

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Werkman:2017:10.1186/s13071-017-2177-6,
author = {Werkman, M and Truscott, JE and Toor, J and Wright, JE and Anderson, RM},
doi = {10.1186/s13071-017-2177-6},
journal = {Parasites & Vectors},
title = {The past matters: estimating intrinsic hookworm transmission intensity inareas with past mass drug administration to control lymphatic filariasis},
url = {http://dx.doi.org/10.1186/s13071-017-2177-6},
volume = {10},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundCurrent WHO guidelines for soil-transmitted helminth (STH) control focus on mass drug administration (MDA) targeting preschool-aged (pre-SAC) and school-aged children (SAC), with the goal of eliminating STH as a public health problem amongst children. Recently, attention and funding has turned towards the question whether MDA alone can result in the interruption of transmission for STH. The lymphatic filariasis (LF) elimination programme, have been successful in reaching whole communities. There is the possibility of building upon the infrastructure created for these LF-programmes to enhance the control of STH. Using hookworm as an example, we explore what further MDA coverage might be required to induce interruption of transmission for hookworm in the wake of a successful LF programme.ResultsAnalyses based on the model of STH transmission and MDA impact predict the effects of previous LF control by MDA over five years, on a defined baseline prevalence of STH in an area with a defined transmission intensity (the basic reproductive number R0). If the LF MDA programme achieved a high coverage (70, 70 and 60% for pre-SAC, SAC and adults, respectively) we expect that in communities with a hookworm prevalence of 15%, after 5 years of LF control, the intrinsic R0 value in that setting is 2.47. By contrast, if lower LF coverages were achieved (40, 40 and 30% for pre-SAC, SAC and adults, respectively), with the same prevalence of 15% at baseline (after 5 years of LF MDA), the intrinsic hookworm R0 value is predicted to be 1.67. The intrinsic R0 value has a large effect on the expected successes of follow-up STH programmes post LF MDA. Consequently, the outcomes of identical programmes may differ between these communities.ConclusionTo design the optimal MDA intervention to eliminate STH infections, it is vital to have information on historical MDA programmes and baseline prevalence to estimate the intrinsic transmission intensity for the defined setting (R0). The b
AU  - Werkman,M
AU  - Truscott,JE
AU  - Toor,J
AU  - Wright,JE
AU  - Anderson,RM
DO  - 10.1186/s13071-017-2177-6
PY  - 2017///
SN  - 1756-3305
TI  - The past matters: estimating intrinsic hookworm transmission intensity inareas with past mass drug administration to control lymphatic filariasis
T2  - Parasites & Vectors
UR  - http://dx.doi.org/10.1186/s13071-017-2177-6
UR  - http://hdl.handle.net/10044/1/48248
VL  - 10
ER  -
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