Imperial College London
Alternate

Professor Sir Roy Anderson FRS, FMedSci

Faculty of Medicine, School of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

roy.anderson Website

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)7766 331 301

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Farrell:2018:10.1186/s13071-018-2670-6,
author = {Farrell, SH and Anderson, RM},
doi = {10.1186/s13071-018-2670-6},
journal = {PARASITES & VECTORS},
title = {Helminth lifespan interacts with noncompliance in reducing the effectiveness of anthelmintic treatment},
url = {http://dx.doi.org/10.1186/s13071-018-2670-6},
volume = {11},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe success of mass drug administration programmes targeting the soil-transmitted helminths and schistosome parasites is in part dependent on compliance to treatment at sequential rounds of mass drug administration (MDA). The impact of MDA is vulnerable to systematic non-compliance, defined as a portion of the eligible population remaining untreated over successive treatment rounds. The impact of systematic non-compliance on helminth transmission dynamics - and thereby on the number of treatment rounds required to interrupt transmission - is dependent on the parasitic helminth being targeted by MDA.ResultsHere, we investigate the impact of adult parasite lifespan in the human host and other factors that determine the magnitude of the basic reproductive number R 0 , on the number of additional treatment rounds required in a target population, using mathematical models of Ascaris lumbricoides and Schistosoma mansoni transmission incorporating systematic non-compliance. Our analysis indicates a strong interaction between helminth lifespan and the impact of systematic non-compliance on parasite elimination, and confirms differences in its impact between Ascaris and the schistosome parasites in a streamlined model structure.ConclusionsOur analysis suggests that achieving reductions in the level of systematic non-compliance may be of particular benefit in mass drug administration programmes treating the longer-lived helminth parasites, and highlights the need for improved data collection in understanding the impact of compliance.
AU  - Farrell,SH
AU  - Anderson,RM
DO  - 10.1186/s13071-018-2670-6
PY  - 2018///
SN  - 1756-3305
TI  - Helminth lifespan interacts with noncompliance in reducing the effectiveness of anthelmintic treatment
T2  - PARASITES & VECTORS
UR  - http://dx.doi.org/10.1186/s13071-018-2670-6
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000423884700002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/62087
VL  - 11
ER  -
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