Imperial College London
Alternate

ProfessorRylieGreen

Faculty of Engineering, Department of Bioengineering

Head of the Department of Bioengineering
 
 
 
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Contact

 

+44 (0)20 7594 0943rylie.green

 
 
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Location

 

3.05Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Peressotti:2021:10.1021/acsbiomaterials.1c00030,
author = {Peressotti, S and Koehl, GE and Goding, JA and Green, RA},
doi = {10.1021/acsbiomaterials.1c00030},
journal = {ACS Biomaterials Science and Engineering},
pages = {4136--4163},
title = {Self-assembling hydrogel structures for neural tissue repair},
url = {http://dx.doi.org/10.1021/acsbiomaterials.1c00030},
volume = {7},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Hydrogel materials have been employed as biological scaffolds for tissue regeneration across a wide range of applications. Their versatility and biomimetic properties make them an optimal choice for treating the complex and delicate milieu of neural tissue damage. Aside from finely tailored hydrogel properties, which aim to mimic healthy physiological tissue, a minimally invasive delivery method is essential to prevent off-target and surgery-related complications. The specific class of injectable hydrogels termed self-assembling peptides (SAPs), provide an ideal combination of in situ polymerization combined with versatility for biofunctionlization, tunable physicochemical properties, and high cytocompatibility. This review identifies design criteria for neural scaffolds based upon key cellular interactions with the neural extracellular matrix (ECM), with emphasis on aspects that are reproducible in a biomaterial environment. Examples of the most recent SAPs and modification methods are presented, with a focus on biological, mechanical, and topographical cues. Furthermore, SAP electrical properties and methods to provide appropriate electrical and electrochemical cues are widely discussed, in light of the endogenous electrical activity of neural tissue as well as the clinical effectiveness of stimulation treatments. Recent applications of SAP materials in neural repair and electrical stimulation therapies are highlighted, identifying research gaps in the field of hydrogels for neural regeneration.
AU  - Peressotti,S
AU  - Koehl,GE
AU  - Goding,JA
AU  - Green,RA
DO  - 10.1021/acsbiomaterials.1c00030
EP  - 4163
PY  - 2021///
SN  - 2373-9878
SP  - 4136
TI  - Self-assembling hydrogel structures for neural tissue repair
T2  - ACS Biomaterials Science and Engineering
UR  - http://dx.doi.org/10.1021/acsbiomaterials.1c00030
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000696370300053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.acs.org/doi/10.1021/acsbiomaterials.1c00030
UR  - http://hdl.handle.net/10044/1/94164
VL  - 7
ER  -
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