Publications
83 results found
Hull DN, Williams RO, Pathan E, et al., 2015, Anti-tumour necrosis factor treatment increases circulating T helper type 17 cells similarly in different types of inflammatory arthritis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 181, Pages: 401-406, ISSN: 0009-9104
- Author Web Link
- Cite
- Citations: 31
Zeun P, Thoms B, Shivji S, et al., 2015, Stubbing it out: tackling smoking in rheumatology clinics, RHEUMATOLOGY, Vol: 54, Pages: 1528-1530, ISSN: 1462-0324
- Author Web Link
- Cite
- Citations: 3
Negoescu AF, Abraham SM, 2015, Anti-Jo1 Antibody in Polymyositis/dermatomyositis Is Still Closely Associated with Lung rather than Joints reply, JOURNAL OF RHEUMATOLOGY, Vol: 42, ISSN: 0315-162X
Ambrose N, Khan E, Ravindran R, et al., 2015, The exaggerated inflammatory response in behçet's syndrome: Identification of dysfunctional post-transcriptional regulation of the IFN?/CXCL10 (IP-10) pathway, Clinical and Experimental Immunology, Vol: 181, Pages: 427-433, ISSN: 1365-2249
The mechanisms underlying the exaggerated inflammatory response in Behçet's syndrome (BS) remain poorly understood. We investigated the response of CD14+ blood monocytes to interferon (IFN)-γ, focusing on the chemokine CXCL10. Chemokine synthesis and release were analysed at a protein and mRNA level following stimulation with IFN-γ. Findings in BS patients were compared with 25 healthy controls (HC), 15 rheumatoid arthritis (RA) and 15 systemic lupus erythematosus (SLE) disease control patients. BS monocytes produced significantly more CXCL10 protein than HC monocytes from 2 h following IFN-γ stimulation, despite equivalent quantities of mRNA, suggesting more efficient translation. This was significantly more pronounced in BS with high disease activity and in those with ocular and neurological clinical manifestations. The imbalance between CXCL10 protein and mRNA expression was not observed in either RA or SLE patients, and was not seen with other chemokines studied (CXCL9, CXCL11 and CCL2). Furthermore, BS monocytes treated with an alternative stimulant (LPS) did not show abnormal tumour necrosis factor (TNF)-α release. Sucrose density gradients to segregate monocyte CXCL10 mRNA into free RNA or polysome-associated RNA showed equal proportions in BS and HC samples, suggesting that the difference between BS and HC may be due to reduced negative control of CXCL10 translation in BS at a post-initiation level. We conclude that BS monocytes have dysfunctional post-transcriptional regulation of CXCL10 mRNA, resulting in over-expression of CXCL10 protein upon IFN-γ stimulation. As CXCL10 is a chemokine that recruits mononuclear cells, this abnormality may contribute to the exaggerated inflammatory responses that characterizes BS.
Timmis AL, Lenman M, Castagno S, et al., 2015, LIFESTYLE CHOICES AND KNOWLEDGE BASE IN PATIENTS WITH PSORIATIC ARTHRITIS: A QUALITATIVE AUDIT, Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: 193-193, ISSN: 1462-0324
Timmis AL, Lenman M, Castagno S, et al., 2015, INVOLVEMENT AND SATISFACTION IN PATIENTS WITH PSORIATIC ARTHRITIS: A QUALITATIVE AUDIT, Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: 199-199, ISSN: 1462-0324
Negoescu AF, Tennekone D, Soljak MA, et al., 2014, Extraarticular Manifestations of Rheumatoid Arthritis Develop in Patients Receiving Anti-Tumor Necrosis Factor-α Treatment: A Retrospective Chart Review from a UK Center, JOURNAL OF RHEUMATOLOGY, Vol: 41, Pages: 1944-1947, ISSN: 0315-162X
- Author Web Link
- Cite
- Citations: 5
Lenman M, Abraham S, 2014, Diagnosis and management of psoriatic arthropathy in primary care, BRITISH JOURNAL OF GENERAL PRACTICE, Vol: 64, Pages: 424-425, ISSN: 0960-1643
- Author Web Link
- Cite
- Citations: 6
Hull D, Abraham S, Williams RO, et al., 2014, INCREASE IN CIRCULATING TH17 CELLS DURING ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS PATIENTS IS ASSOCIATED WITH IMPROVEMENT IN JOINT INFLAMMATION, 15th Annual European Congress of Rheumatology (EULAR), Publisher: BMJ PUBLISHING GROUP, Pages: 236-236, ISSN: 0003-4967
Ali O, Narshi C, Khanna M, et al., 2014, A painful swollen thigh in a diabetic patient: diabetic myonecrosis, LANCET, Vol: 383, Pages: 1860-1860, ISSN: 0140-6736
- Author Web Link
- Cite
- Citations: 2
Isaacs A, Abraham S, 2014, CLINICAL EFFECTIVENESS OF CERTOLIZUMAB PEGOL IN THE TREATMENT OF RHEUMATOID ARTHRITIS: A MULTICENTRE STUDY, Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: 109-109, ISSN: 1462-0324
Hull DN, Abraham S, Pathan E, et al., 2014, ANTI-TNF THERAPY LEADS TO AN INCREASE IN CIRCULATING TH17 CELLS IN PATIENTS WITH DIFFERENT TYPES OF INFLAMMATORY ARTHRITIS AND IS ASSOCIATED WITH ULTRASONOGRAPHIC IMPROVEMENT OF SYNOVITIS, Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: 42-43, ISSN: 1462-0324
Hull D, Abraham S, Williams R, et al., 2014, Circulating Th17 cells and joint inflammation during anti-tumour necrosis factor therapy in rheumatoid arthritis, LANCET, Vol: 383, Pages: 58-58, ISSN: 0140-6736
- Author Web Link
- Cite
- Citations: 1
Isaacs A, Chryssanthakis A, Abraham S, 2013, A cross-sectional audit of the uptake of the seasonal influenza vaccination by medical staff at a London hospital, CLINICAL MEDICINE, Vol: 13, Pages: 633-633, ISSN: 1470-2118
- Author Web Link
- Cite
- Citations: 1
Pathan E, Lim A, Graham A, et al., 2013, Quantification Of Inflammatory Disease Of Spine In Ankylosing Spondylitis Using Volumetric Magnetic Resonance Imaging Analysis., 77th Annual Meeting of the American-College-of-Rheumatology / 48th Annual Meeting of the Association-of-Rheumatology-Health-Professionals, Publisher: WILEY-BLACKWELL, Pages: S474-S475, ISSN: 0004-3591
Pathan E, Abraham S, Van Rossen E, et al., 2013, Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in ankylosing spondylitis, ANNALS OF THE RHEUMATIC DISEASES, Vol: 72, Pages: 1475-1480, ISSN: 0003-4967
- Author Web Link
- Cite
- Citations: 76
Negoescu A-FF, Abraham SM, 2013, EXTRA-ARTICULAR MANIFESTATIONS OF RHEUMATOID ARTHRITIS DEVELOP IN PATIENTS RECEIVING ANTI-TNF TREATMENT -A RETROSPECTIVE STUDY, ANNALS OF THE RHEUMATIC DISEASES, Vol: 72, Pages: 222-222, ISSN: 0003-4967
Mehta P, Lukacs M, Abraham SM, 2012, Normal in the blood, abnormal in the urine, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 105, Pages: 1001-1002, ISSN: 1460-2725
- Author Web Link
- Cite
- Citations: 2
Alzabin S, Abraham SM, Taher TE, et al., 2012, Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway, ANNALS OF THE RHEUMATIC DISEASES, Vol: 71, Pages: 1741-1748, ISSN: 0003-4967
- Author Web Link
- Cite
- Citations: 118
Mouyis M, Abraham S, 2012, Smoking: keeping the joint alight, CLINICAL MEDICINE, Vol: 12, Pages: 399-400, ISSN: 1470-2118
Abraham S, Augustine J, Thomas TD, 2012, Asymbiotic seed germination and in vitro conservation of Coelogyne nervosa A. Rich. an endemic orchid to Western Ghats., Physiol Mol Biol Plants, Vol: 18, Pages: 245-251, ISSN: 0971-5894
Coelogyne nervosa is an epiphytic orchid endemic to Western Ghats, South India. The mature seeds of C. nervosa were cultured on ½ MS (Murashige and Skoog), MS, Kn (Knudson) and VW (Vacin and Went) media to evaluate the seed germination response. Of the four basal media used, MS medium supported maximum seed germination. Further experiments to enhance seed germination were done on MS medium supplemented with various concentrations (10, 20, 30 and 40 %) of coconut water (CW). Thirty percent CW gave the highest response in terms of percent seed germination (96), fresh weight (7.2 mg/seedling) and protocorm length (15.2 mm). Since CW containing medium did not support further seedling growth, each seedling was isolated and cultured on MS medium supplemented with either BA (6-benzylaminopurine) or Kin (kinetin) alone (1.0-4.0 mg/l each) or in combination with NAA (1-naphthaleneacetic acid; 0.2-1.0 mg/l). Maximum growth was observed on MS medium supplemented with BA (3.0 mg/l) and NAA (0.5 mg/l). On this medium, the seedlings reached an average length of 3.6 cm with 2.8 well expanded green leaves per seedling. Similarly optimum, healthy, white root induction (3.3 roots/seedlings) was also observed on the same medium. The rooted seedlings were successfully transplanted to pots with 91 % success. The 2-year-old tissue culture derived plants produced normal flowers and fruits.
Maruthappu T, Abraham S, Weir J, et al., 2012, A rare case of calcific panniculitis associated with dermatomyositis, 92nd Annual Meeting of the British-Association-of-Dermatologists, Publisher: WILEY-BLACKWELL, Pages: 110-111, ISSN: 0007-0963
Vattakuzhi Y, Abraham SM, Freidin A, et al., 2012, Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis, ARTHRITIS AND RHEUMATISM, Vol: 64, Pages: 2201-2210, ISSN: 0004-3591
- Author Web Link
- Cite
- Citations: 32
Hull D, Ball C, Abraham S, 2012, ANTI-TNF THERAPY IMPROVES HAND FUNCTION IN RHEUMATOID ARTHRITIS WITHIN 3 MONTHS, Annual Meeting of the British-Society-for-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: 136-136, ISSN: 1462-0324
Alzabin S, Abraham S, Taher TE, et al., 2012, INCOMPLETE RESPONSE OF INFLAMMATORY ARTHRITIS TO TNFα BLOCKADE IS ASSOCIATED WITH THE TH17 PATHWAY, RHEUMATOLOGY, Vol: 51, Pages: 122-122, ISSN: 1462-0324
Bhaduri M, Smith A, Cook H, et al., 2012, AN AUDIT OF ASSESSING RISK AND TREATING MYCOBACTERIAL INFECTION IN PATIENTS WITH INFLAMMATORY ARTHRITIS PRIOR TO STARTING AN ANTI-TNF AGENT, Annual Meeting of the British-Society-for-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: 66-66, ISSN: 1462-0324
Dhalla F, Gulati P, Sreerangaiah D, et al., 2012, PICTURE QUIZ A man with thrombocytopenia, BRITISH MEDICAL JOURNAL, Vol: 344, ISSN: 0959-535X
Pathan E, Abraham SM, Van-Rossen L, et al., 2011, Efficacy and Safety of Apremilast, An Oral Phosphodiesterase Inhibitor, in Ankylosing Spondylitis, 75th Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) / 46th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals (ARHP), Publisher: WILEY, Pages: S646-S646, ISSN: 0004-3591
- Author Web Link
- Cite
- Citations: 2
Mangat P, Abraham S, 2011, How should we best manage patients with immune-mediated inflammatory disease on immunosuppressant therapy during the 'swine flu' pandemic?, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 104, Pages: 269-270, ISSN: 1460-2725
Mangat P, Taylor P, Abraham S, 2011, Respiratory symptoms in a patient on anti-tumour necrosis factor therapy; beware the negative enzyme linked immuno-spot (ELISpot) in suspected mycobacterial disease, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 104, Pages: 61-63, ISSN: 1460-2725
- Author Web Link
- Cite
- Citations: 1
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.