Imperial College London
Alternate

DrSonyaAbraham

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 4114s.abraham

 
 
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Location

 

Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Helo:2020:10.1186/s13550-020-00736-9,
author = {Helo, Y and Searle, GE and Borgheese, F and Abraham, S and Azeem, S},
doi = {10.1186/s13550-020-00736-9},
journal = {EJNMMI Research},
title = {Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease},
url = {http://dx.doi.org/10.1186/s13550-020-00736-9},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveExpression of the translocator protein (TSPO) on inflammatory cells has facilitated imaging of synovitis with TSPO-targeted positron emission tomography (PET). We aimed to quantitatively assess the specificity of the second-generation TSPO PET radioligand, [11C]PBR28, and to generate simplified PET protocols in patients with inflammatory joint disease (IJD) in this pilot study.MethodsThree IJD patients (two rheumatoid arthritis and one osteoarthritis) with knee involvement underwent dynamic [11C]PBR28-PET scans before and after administration of 90 mg of oral emapunil (XBD-173), a TSPO ligand the same day. Radial arterial blood sampling was performed throughout the scan, and total radioactivity and radioactive metabolites were obtained. A semi-automated method was used to generate regions of interest. Standardized uptake value (SUV) and SUV ratio corrected for activity in bone and blood between 50 and 70 min (SUVr50–70 bone, SUVr50–70 blood, respectively) and PET volume of distribution (VT) of the radioligand were calculated.ResultsA mean [11C]PBR28 radioactivity of 378 (range 362–389) MBq was administered. A significant decrease (p < 0.05) in VT, SUVr50–70 bone and SUVr50–70 blood observed after oral emapunil confirmed the TSPO specificity of [11C]PBR28. A decrease in SUV was not observed in the post-block scan.Conclusion[11C]PBR28 is TSPO-specific radioligand in IJD patients. Simplified PET protocols with static PET acquisition can be used in the management and evaluation of novel therapeutics that target TSPO overexpressing cells.
AU  - Helo,Y
AU  - Searle,GE
AU  - Borgheese,F
AU  - Abraham,S
AU  - Azeem,S
DO  - 10.1186/s13550-020-00736-9
PY  - 2020///
SN  - 2191-219X
TI  - Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease
T2  - EJNMMI Research
UR  - http://dx.doi.org/10.1186/s13550-020-00736-9
UR  - http://hdl.handle.net/10044/1/85776
VL  - 10
ER  -
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