Imperial College London
Alternate

DrSonyaAbraham

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 4114s.abraham

 
 
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Location

 

Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sreerangaiah:2016:rheumatology/kev305,
author = {Sreerangaiah, D and Grayer, M and Fisher, BA and Ho, M and Abraham, S and Taylor, PC},
doi = {rheumatology/kev305},
journal = {Rheumatology},
pages = {89--93},
title = {Quantitative power Doppler ultrasound measures of peripheral joint synovitis in poor prognosis early rheumatoid arthritis predict radiographic progression},
url = {http://dx.doi.org/10.1093/rheumatology/kev305},
volume = {55},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective. To assess the value of quantitative vascular imaging by power Doppler US (PDUS) as a tool that can be used to stratify patient risk of joint damage in early seropositive RA while still biologic naive but on synthetic DMARD treatment.Methods. Eighty-five patients with seropositive RA of <3 years duration had clinical, laboratory and imaging assessments at 0 and 12 months. Imaging assessments consisted of radiographs of the hands and feet, two-dimensional (2D) high-frequency and PDUS imaging of 10 MCP joints that were scored for erosions and vascularity and three-dimensional (3D) PDUS of MCP joints and wrists that were scored for vascularity.Results. Severe deterioration on radiographs and ultrasonography was seen in 45 and 28% of patients, respectively. The 3D power Doppler volume and 2D vascularity scores were the most useful US predictors of deterioration. These variables were modelled in two equations that estimate structural damage over 12 months. The equations had a sensitivity of 63.2% and specificity of 80.9% for predicting radiographic structural damage and a sensitivity of 54.2% and specificity of 96.7% for predicting structural damage on ultrasonography.Conclusion. In seropositive early RA, quantitative vascular imaging by PDUS has clinical utility in predicting which patients will derive benefit from early use of biologic therapy.
AU  - Sreerangaiah,D
AU  - Grayer,M
AU  - Fisher,BA
AU  - Ho,M
AU  - Abraham,S
AU  - Taylor,PC
DO  - rheumatology/kev305
EP  - 93
PY  - 2016///
SN  - 1462-0332
SP  - 89
TI  - Quantitative power Doppler ultrasound measures of peripheral joint synovitis in poor prognosis early rheumatoid arthritis predict radiographic progression
T2  - Rheumatology
UR  - http://dx.doi.org/10.1093/rheumatology/kev305
VL  - 55
ER  -
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