Imperial College London
Alternate

DrSonyaAbraham

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 4114s.abraham

 
 
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Location

 

Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lim:2017:10.1007/s00330-017-5016-4,
author = {Lim, AKP and Satchithananda, K and Dick, EA and Abraham, S and Cosgrove, DO},
doi = {10.1007/s00330-017-5016-4},
journal = {European Radiology},
pages = {1046--1053},
title = {Microflow imaging: new Doppler technology to detect low-grade inflammation in patients with arthritis},
url = {http://dx.doi.org/10.1007/s00330-017-5016-4},
volume = {28},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIM: To assess the efficacy of microvascular imaging in detecting low-grade inflammation in arthritis compared with Power Doppler ultrasound (PDUS). METHOD AND MATERIALS: Patients presenting for ultrasound with arthralgia were assessed with grey-scale, PDUS and Superb Microvascular Imaging (SMI). Videoclips were stored for analysis at a later date. Three musculoskeletal radiologists scored grey-scale changes, signal on PDUS and/or SMI within these joints. If a signal was detected on both PDUS and SMI, the readers graded the conspicuity of vascular signal from the two Doppler techniques using a visual analogue scale. RESULTS: Eighty-three patients were recruited with 134 small joints assessed. Eighty-nine of these demonstrated vascular flow with both PD and SMI, whilst in five no flow was detected. In 40 joints, vascularity was detected with SMI but not with PDUS (p = 0.007). Out of the 89 joints with vascularity on both SMI and PDUS, 23 were rated as being equal; while SMI scored moderately or markedly better in 45 cases (p <0.001). CONCLUSION: SMI is a new Doppler technique that increases conspicuity of Doppler vascularity in symptomatic joints when compared to PDUS. This allows detection of low grade inflammation not visualised with Power Doppler in patients with arthritis. KEY POINTS: • SMI detects vascularity with improved resolution and sensitivity compared to Power Doppler. • SMI can detect low-grade inflammation not seen with Power Doppler. • Earlier detection of active inflammation could have significant impact on treatment paradigms.
AU  - Lim,AKP
AU  - Satchithananda,K
AU  - Dick,EA
AU  - Abraham,S
AU  - Cosgrove,DO
DO  - 10.1007/s00330-017-5016-4
EP  - 1053
PY  - 2017///
SN  - 0938-7994
SP  - 1046
TI  - Microflow imaging: new Doppler technology to detect low-grade inflammation in patients with arthritis
T2  - European Radiology
UR  - http://dx.doi.org/10.1007/s00330-017-5016-4
UR  - http://hdl.handle.net/10044/1/54944
VL  - 28
ER  -
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