Stefan Antonowicz PhD FRCS is a Clinical Senior Lecturer at Imperial College London and Honorary Consultant Surgeon at Imperial College Healthcare Trust.
His doctoral research involved dissecting the molecular mechanisms underpinning exhaled breath biomarkers of oeosphagogastric cancer. Through two papers (Cancer Research 2020, Nat Comms 2021) he showed a tumour-lipid origin for exhaled reactive carbonyls (RCs), and characterised the molecular cause and functional effects of this metabolic reprogramming. This work led to an improved breath test for upper GI cancer through cognisant augmented sampling and optimised analytics, and supported the validation of this test in two programme grants led by George Hanna's lab.
Current research activities include:
1. Ongoing characterisation of breath test mechanisms in upper gastrointestinal cancers, including the role of amino acids, the microbiome, and the cellular and non-cellular components of the tumour microenviroment
2. Affiliated metabolic phenotypes of targetable genetic events, in particular how ERBB2 amplication is linked to glycerophospholipid reprogramming
3. Tumour metabolic heterogeneity as a source of treatment resistance and refined treatment strategies.
Internal appoitnments include leading Module 1 for the intercalated BSc in Surgical Design technology and Innovation, and leading the general surgery clinical academic training program at Imperial. He is a reviewer for Cancer Research, Disease of the Esophagus, Plos One and other cancer journals.
Clinically he completed undergraduate medical education at Leicester. He subsequently completed his clinical training in London and Oxford, and is currently a Consultant Surgeon at Imperial specialising in major oesophagogastric cancer resections.