Imperial College London
Alternate

DrSonyaBabu-Narayan

Faculty of Medicine, National Heart & Lung Institute

Reader in Adult Congenital Heart Disease
 
 
 
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Contact

 

+44 (0)20 7351 8803s.babu-narayan

 
 
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Location

 

NIHR Cardiovascular Biomedical RChelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ghonim:2020:10.1161/CIRCEP.119.008321,
author = {Ghonim, S and Ernst, S and Keegan, J and Giannakidis, A and Spadotto, V and Voges, I and Smith, G and Boutsikou, M and Montanaro, C and Wong, T and Ho, SY and McCarthy, K and Shore, D and Dimopoulos, K and Uebing, A and Swan, L and Li, W and Pennell, D and Gatzoulis, M and Babu-Narayan, S},
doi = {10.1161/CIRCEP.119.008321},
journal = {Circulation: Arrhythmia and Electrophysiology},
pages = {1331--1341},
title = {3D late gadolinium enhancement cardiovascular magnetic resonance predicts inducibility of ventricular tachycardia in adults with repaired tetralogy of Fallot},
url = {http://dx.doi.org/10.1161/CIRCEP.119.008321},
volume = {13},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background - Adults with repaired tetralogy of Fallot (rTOF) die prematurely from ventricular tachycardia (VT) and sudden cardiac death. Inducible VT predicts mortality. Ventricular scar, the key substrate for VT, can be non-invasively defined with late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) but whether this relates to inducible VT is unknown.Methods - Sixty-nine consecutive rTOF patients (43 male, mean 40{plus minus}15 years) clinically scheduled for invasive programmed VT-stimulation were prospectively recruited for prior 3D LGE CMR. Ventricular LGE was segmented and merged with reconstructed cardiac chambers and LGE volume measured.Results - VT was induced in 22(31%) patients. Univariable predictors of inducible VT included increased RV LGE (OR 1.15;p=0.001 per cm3), increased non-apical vent LV LGE (OR 1.09;p=0.008 per cm3), older age (OR 1.6;p=0.01 per decile), QRS duration ≥180ms (OR 3.5;p=0.02), history of non-sustained VT (OR 3.5; p=0.02) and previous clinical sustained VT (OR 12.8;p=0.003); only prior sustained VT (OR 8.02;p=0.02) remained independent in bivariable analyses after controlling for RV LGE volume (OR 1.14;p=0.003). An RV LGE volume of 25cm3 had 72% sensitivity and 81% specificity for predicting inducible VT (AUC 0.81;p<0.001). At the extreme cutoffs for 'ruling-out' and 'ruling-in' inducible VT, RV LGE >10cm3 was 100% sensitive and >36cm3 was 100% specific for predicting inducible VT.Conclusions - 3D LGE CMR-defined scar burden is independently associated with inducible VT and may help refine patient selection for programmed VT-stimulation when applied to an at least intermediate clinical risk cohort.
AU  - Ghonim,S
AU  - Ernst,S
AU  - Keegan,J
AU  - Giannakidis,A
AU  - Spadotto,V
AU  - Voges,I
AU  - Smith,G
AU  - Boutsikou,M
AU  - Montanaro,C
AU  - Wong,T
AU  - Ho,SY
AU  - McCarthy,K
AU  - Shore,D
AU  - Dimopoulos,K
AU  - Uebing,A
AU  - Swan,L
AU  - Li,W
AU  - Pennell,D
AU  - Gatzoulis,M
AU  - Babu-Narayan,S
DO  - 10.1161/CIRCEP.119.008321
EP  - 1341
PY  - 2020///
SN  - 1941-3084
SP  - 1331
TI  - 3D late gadolinium enhancement cardiovascular magnetic resonance predicts inducibility of ventricular tachycardia in adults with repaired tetralogy of Fallot
T2  - Circulation: Arrhythmia and Electrophysiology
UR  - http://dx.doi.org/10.1161/CIRCEP.119.008321
UR  - https://www.ahajournals.org/doi/10.1161/CIRCEP.119.008321
UR  - http://hdl.handle.net/10044/1/83626
VL  - 13
ER  -
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