Imperial College London
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ProfessorSamirBhatt

Faculty of Medicine, School of Public Health

Professor of Statistics and Public Health
 
 
 
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Contact

 

+44 (0)20 7594 5029s.bhatt

 
 
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Location

 

G32ASt Mary's Research BuildingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Faria:2021:10.1126/science.abh2644,
author = {Faria, NR and Mellan, TA and Whittaker, C and Claro, IM and Candido, DDS and Mishra, S and Crispim, MAE and Sales, FC and Hawryluk, I and McCrone, JT and Hulswit, RJG and Franco, LAM and Ramundo, MS and de, Jesus JG and Andrade, PS and Coletti, TM and Ferreira, GM and Silva, CAM and Manuli, ER and Pereira, RHM and Peixoto, PS and Kraemer, MU and Gaburo, N and Camilo, CDC and Hoeltgebaum, H and Souza, WM and Rocha, EC and de, Souza LM and de, Pinho MC and Araujo, LJT and Malta, FS and de, Lima AB and Silva, JDP and Zauli, DAG and Ferreira, ACDS and Schnekenberg, RP and Laydon, DJ and Walker, PGT and Schlueter, HM and dos, Santos ALP and Vidal, MS and Del, Caro VS and Filho, RMF and dos, Santos HM and Aguiar, RS and Proenca-Modena, JLP and Nelson, B and Hay, JA and Monod, M and Miscouridou, X and Coupland, H and Sonabend, R and Vollmer, M and Gandy, A and Prete, CA and Nascimento, VH and Suchard, MA and Bowden, TA and Pond, SLK and Wu, C-H and Ratmann, O and Ferguson, NM and Dye, C and L},
doi = {10.1126/science.abh2644},
journal = {Science},
pages = {815--821},
title = {Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil},
url = {http://dx.doi.org/10.1126/science.abh2644},
volume = {372},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in the spike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2 (angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% of the protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced global genomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immune evasion, is critical to accelerate pandemic responsiveness.
AU  - Faria,NR
AU  - Mellan,TA
AU  - Whittaker,C
AU  - Claro,IM
AU  - Candido,DDS
AU  - Mishra,S
AU  - Crispim,MAE
AU  - Sales,FC
AU  - Hawryluk,I
AU  - McCrone,JT
AU  - Hulswit,RJG
AU  - Franco,LAM
AU  - Ramundo,MS
AU  - de,Jesus JG
AU  - Andrade,PS
AU  - Coletti,TM
AU  - Ferreira,GM
AU  - Silva,CAM
AU  - Manuli,ER
AU  - Pereira,RHM
AU  - Peixoto,PS
AU  - Kraemer,MU
AU  - Gaburo,N
AU  - Camilo,CDC
AU  - Hoeltgebaum,H
AU  - Souza,WM
AU  - Rocha,EC
AU  - de,Souza LM
AU  - de,Pinho MC
AU  - Araujo,LJT
AU  - Malta,FS
AU  - de,Lima AB
AU  - Silva,JDP
AU  - Zauli,DAG
AU  - Ferreira,ACDS
AU  - Schnekenberg,RP
AU  - Laydon,DJ
AU  - Walker,PGT
AU  - Schlueter,HM
AU  - dos,Santos ALP
AU  - Vidal,MS
AU  - Del,Caro VS
AU  - Filho,RMF
AU  - dos,Santos HM
AU  - Aguiar,RS
AU  - Proenca-Modena,JLP
AU  - Nelson,B
AU  - Hay,JA
AU  - Monod,M
AU  - Miscouridou,X
AU  - Coupland,H
AU  - Sonabend,R
AU  - Vollmer,M
AU  - Gandy,A
AU  - Prete,CA
AU  - Nascimento,VH
AU  - Suchard,MA
AU  - Bowden,TA
AU  - Pond,SLK
AU  - Wu,C-H
AU  - Ratmann,O
AU  - Ferguson,NM
AU  - Dye,C
AU  - Loman,NJ
AU  - Lemey,P
AU  - Rambaut,A
AU  - Fraiji,NA
AU  - Carvalho,MDPSS
AU  - Pybus,OG
AU  - Flaxman,S
AU  - Bhatt,S
AU  - Sabino,EC
DO  - 10.1126/science.abh2644
EP  - 821
PY  - 2021///
SN  - 0036-8075
SP  - 815
TI  - Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil
T2  - Science
UR  - http://dx.doi.org/10.1126/science.abh2644
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000653997000037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.science.org/doi/10.1126/science.abh2644
UR  - http://hdl.handle.net/10044/1/92015
VL  - 372
ER  -
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