Publications
2554 results found
Ward AS, Bloom SR, 1974, The role of secretin in the inhibition of gastric secretion by intraduodenal acid., Gut, Vol: 15, Pages: 889-897, ISSN: 0017-5749
The effect of intraduodenal acid on pentagastrin-stimulated gastric secretion has been investigated in 12 normal subjects and 23 patients with chronic duodenal ulceration. Plasma secretin levels were monitored during each test using a highly sensitive radioimmunoassay. Significant inhibition of gastric secretion occurred in the normal subjects and duodenal ulcer patients. A significant rise in plasma secretin was observed in both groups after intraduodenal acid though there was a complete lack of correlation between the magnitude of the secretin response and the degree of gastric inhibition. Ten subjects received intraduodenal acid and a subsequent intravenous infusion of exogenous secretin (0.125-0.25 units/kg over six minutes). Gastric inhibition occurred after the acid instillation but not after secretin infusion despite plasma secretin levels greatly in excess of those produced by intraduodenal acid. These results suggest that release of secretin by itself cannot explain the gastric inhibitory response to intraduodenal acid in man.
Bearn JG, Bloom SR, Brocklehurst ES, et al., 1974, Proceedings: Plasma pancreatic glucagon, plasma insulin and blood glucose studies in the fetal rabbit., J Anat, Vol: 118, ISSN: 0021-8782
Alford FP, Bloom SR, Nabarro JD, et al., 1974, Glucagon control of fasting glucose in man., Lancet, Vol: 2, Pages: 974-977, ISSN: 0140-6736
Royston CM, Polak JM, Bloom S, et al., 1974, Proceedings: The G cell population of the gastric antrum, plasma gastrin, and gastrin acid secretion., Gut, Vol: 15, Pages: 840-841, ISSN: 0017-5749
Russell RC, Thomson JP, Bloom SR, 1974, The effect of truncal and selective vagotomy on the release of pancreatic glucagon, insulin and enteroglucagon., Br J Surg, Vol: 61, Pages: 821-824, ISSN: 0007-1323
Fielding LP, Russell RC, Bloom SR, 1974, Proceedings: Provoking gastrin release--which stimulus?, Gut, Vol: 15, ISSN: 0017-5749
Turner DS, Etheridge L, Jones J, et al., 1974, The effect of the intestinal polypeptides, IRP and GIP, on insulin release and glucose tolerance in the baboon., Clin Endocrinol (Oxf), Vol: 3, Pages: 489-493, ISSN: 0300-0664
Thorner MO, Bloom SR, 1974, Letter: Rapid glucagon release in artificial fever., Lancet, Vol: 2, ISSN: 0140-6736
Bloom SR, Vaughan NJ, Russell RC, 1974, Vagal control of glucagon release in man., Lancet, Vol: 2, Pages: 546-549, ISSN: 0140-6736
A significant fall in fasting plasmapancreatic-glucagon was produced by injection of atropine. After arginine infusion atropine reduced the normal rise of glucagon by 33% and glucose by 40%. Eleven patients studied during insulin hypoglycaemia after a selective vagotomy showed a peak rise in plasma-glucagon of 173 pg. per ml., which was not significantly different from the glucagon rise in ten preoperative controls (168 pg. per ml.). The glucagon response to insulin hypoglycaemia (81 pg. per ml.) in a matched group of ten patients with truncal vagotomy was significantly less than after selective vagotomy. This evidence of parasympathetic control of the alpha cell accords with morphological and laboratory-animal findings. Maintenance of normal glucagon release after selective vagotomy favours the use of this operation rather than the cruder truncal vagotomy.
Mallinson CN, Bloom SR, Warin AP, et al., 1974, A glucagonoma syndrome., Lancet, Vol: 2, Pages: 1-5, ISSN: 0140-6736
Loveridge N, Bloom SR, Welbourn RB, et al., 1974, Quantitative cytochemical estimation of the effect of pentagastrin (0.005-5 pg-ml) and of plasma gastrin on the guinea-pig fundus in vitro., Clin Endocrinol (Oxf), Vol: 3, Pages: 389-396, ISSN: 0300-0664
Bloom SR, 1974, Progress report. Radioimmunoassay of intestinal hormones., Gut, Vol: 15, Pages: 502-510, ISSN: 0017-5749
Mortimer CH, Tunbridge WM, Carr D, et al., 1974, Effects of growth-hormone release-inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic, and hypopituitary patients., Lancet, Vol: 1, Pages: 697-701, ISSN: 0140-6736
Russell RC, Faber RG, Bloom SR, et al., 1974, Proceedings: The effect of vagotomy on gastrin release in response to insulin hypoglycaemia., Br J Surg, Vol: 61, ISSN: 0007-1323
Mallinson CN, Cox B, Bloom SR, 1974, Proceedings: Plasma levels of amino acids and glucagon in patients with pancreatic glucagonomas., Gut, Vol: 15, ISSN: 0017-5749
Spathis GS, Bloom SR, Jeffcoate WJ, et al., 1974, Subcutaneous glucagon as a test of the ability of the pituitary to secrete GH and ACTH., Clin Endocrinol (Oxf), Vol: 3, Pages: 175-186, ISSN: 0300-0664
Bloom SR, Ward AS, 1974, Proceedings: Secretin release in man after intra-duodenal acid., Gut, Vol: 15, ISSN: 0017-5749
Lightman SL, Bloom SR, 1974, Cure of insulin-dependent diabetes mellitus by removal of a glucagonoma., Br Med J, Vol: 1, Pages: 367-368, ISSN: 0007-1447
Edwards AV, Nathanielsz PW, Bloom SR, et al., 1974, The role of thyroxine in the maintenance of a normal glycogenolytic response to splanchnic nerve stimulation in adrenalectomized calves., Experientia, Vol: 30, Pages: 163-164, ISSN: 0014-4754
Bloom SR, Thomson JP, Ogawa O, 1974, Proceedings: Enteroglucagon correlation with insulin release., Clin Sci Mol Med, Vol: 46, ISSN: 0301-0538
Bloom SR, Edwards AV, Vaughan NJ, 1974, The role of the autonomic innervation in the control of glucagon release during hypoglycaemia in the calf., J Physiol, Vol: 236, Pages: 611-623, ISSN: 0022-3751
1. The extent to which the autonomic innervation to the pancreas is implicated in the control of glucagon release during hypoglycaemia has been investigated in calves 3-6 weeks after birth.2. A pronounced rise in plasma glucagon concentration occurred in normal conscious calves in response to hypoglycaemia following administration of insulin (0.1 u./kg). Prior treatment with atropine caused no significant change in the hypoglycaemic response to insulin in these animals but the rise in plasma glucagon concentration was delayed.3. Section of both splanchnic nerves produced no significant change in the tolerance of conscious calves to this small dose of insulin and the changes in plasma glucagon concentration in these animals were within the normal range.4. In contrast, the same dose of insulin produced severe hypoglycaemia, accompanied by convulsions, in atropinized calves with cut splanchnic nerves. In spite of the intensity of the hypoglycaemic stimulus the rise in plasma glucagon concentration was both delayed and diminished in these animals.5. Administration of atropine alone (0.2 mg/kg) to normal fasting calves produced a significant fall in the mean plasma concentrations of both glucose and glucagon (P < 0.01) within 30 min, without affecting that of insulin.6. A significant increase in plasma glucagon concentration also occurred in response to stimulation of the peripheral ends of the thoracic vagi in adrenalectomized calves with cut splanchnic nerves under barbiturate anaesthesia. A rise in mean plasma glucose concentration was also observed in these experiments and found to be significantly correlated with the glucagon response.7. It is concluded that changes in either sympathetic or parasympathetic efferent activity may modify plasma glucagon concentration in the conscious calf, but that only the latter mechanism is likely to be implicated in the response to changes in plasma glucose concentration within the physiological range.
POLAK JM, PEARSE AGE, GARAUD JC, et al., 1974, CELLULAR LOCALIZATION OF A VASOACTIVE INTESTINAL PEPTIDE IN MAMMALIAN AND AVIAN GASTROINTESTINAL-TRACT, GUT, Vol: 15, Pages: 720-724, ISSN: 0017-5749
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- Citations: 150
Mallinson C, Bloom S, 1974, Skin lesion specifically associated with diabetes, anemia and islet cell tumours of the pancreas: report of 7 new cases, Digestion, Vol: 10, Pages: 230-231, ISSN: 0012-2823
PEARSE AGE, POLAK JM, BLOOM SR, et al., 1974, STUDIES ON SECRETIN, ACTA HEPATO-GASTROENTEROLOGICA, Vol: 21, Pages: 477-477, ISSN: 0300-970X
PEARSE AGE, POLAK JM, BLOOM SR, et al., 1974, ENTEROCHROMAFFIN CELLS OF MAMMALIAN SMALL-INTESTINE AS SOURCE OF MOTILIN, VIRCHOWS ARCHIV ABTEILUNG B ZELLPATHOLOGIE, Vol: 16, Pages: 111-120
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- Citations: 158
Bloom SR, 1974, Hormones of the gastrointestinal tract., Br Med Bull, Vol: 30, Pages: 62-67, ISSN: 0007-1420
Bloom SR, 1973, Letter: Radioimmunoassay of cholecystokinin-pancreozymin., Lancet, Vol: 2, Pages: 1272-1273, ISSN: 0140-6736
Bloom SR, Bryant MG, 1973, Proceedings: Distribution of radioimmunoassayable gastrin, secretin, pancreozymin and enteroglucagon in rat, dog, and baboon gut., J Endocrinol, Vol: 59, ISSN: 0022-0795
Polak JM, Pearse AG, Van Noorden S, et al., 1973, Secretin cells in coeliac disease., Gut, Vol: 14, Pages: 870-874, ISSN: 0017-5749
Immunofluorescence (anti-secretin), cytochemical, and ultrastructural studies were carried out on jejunal biopsies from 16 children with coeliac disease and from 17 controls with suspected malabsorption but normal jejunal morphology. In 11 of the 16 coeliacs there was generalized hyperplasia of endocrine cells and, specifically, of the secretin (S) cells. Further studies, on adult coeliacs as well as on children, combined with serum secretin assays, may establish whether the S cells are abnormally storing hormone because of inability to release it or because of excess production.
Swaminathan R, Bates RF, Bloom SR, et al., 1973, The relationship between food, gastro-intestinal hormones and calcitonin secretion., J Endocrinol, Vol: 59, Pages: 217-230, ISSN: 0022-0795
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