Publications
2557 results found
Bloom SR, Bryant MG, 1973, Proceedings: Distribution of radioimmunoassayable gastrin, secretin, pancreozymin and enteroglucagon in rat, dog, and baboon gut., J Endocrinol, Vol: 59, ISSN: 0022-0795
Polak JM, Pearse AG, Van Noorden S, et al., 1973, Secretin cells in coeliac disease., Gut, Vol: 14, Pages: 870-874, ISSN: 0017-5749
Immunofluorescence (anti-secretin), cytochemical, and ultrastructural studies were carried out on jejunal biopsies from 16 children with coeliac disease and from 17 controls with suspected malabsorption but normal jejunal morphology. In 11 of the 16 coeliacs there was generalized hyperplasia of endocrine cells and, specifically, of the secretin (S) cells. Further studies, on adult coeliacs as well as on children, combined with serum secretin assays, may establish whether the S cells are abnormally storing hormone because of inability to release it or because of excess production.
Swaminathan R, Bates RF, Bloom SR, et al., 1973, The relationship between food, gastro-intestinal hormones and calcitonin secretion., J Endocrinol, Vol: 59, Pages: 217-230, ISSN: 0022-0795
Russell RC, Thomson JP, Bloom SR, et al., 1973, Proceedings: gastrin release in response to oral glucose in patients before and after gastric operations., Br J Surg, Vol: 60, ISSN: 0007-1323
Belchetz PE, Brown CL, Makin HL, et al., 1973, ACTH, glucagon and gastrin production by a pancreatic islet cell carcinoma and its treatment., Clin Endocrinol (Oxf), Vol: 2, Pages: 307-316, ISSN: 0300-0664
Mallinson CN, Salmon PR, Borrowman J, et al., 1973, Proceedings: The association of a specific skin lesion with islet-cell tumours of the pancreas., Gut, Vol: 14, ISSN: 0017-5749
Bloom SR, Bryant MG, 1973, Proceedings: The distribution of vasoactive intestinal peptide (VIP) in the primate gastrointestinal tract and characterization of VIP from human tumours., Gut, Vol: 14, ISSN: 0017-5749
Bloom SR, Edwards AV, Vaughan NJ, 1973, The role of the sympathetic innervation in the control of plasma glucagon concentration in the calf., J Physiol, Vol: 233, Pages: 457-466, ISSN: 0022-3751
1. The extent to which the splanchnic sympathetic innervation is implicated in the control of plasma glucagon concentration has been investigated in the young calf.2. Stimulation of the peripheral ends of both splanchnic nerves (0.5-10.0 c/s for 10 min) caused an abrupt increase in plasma glucagon concentration in adrenalectomized calves 3-5 weeks after birth. This effect was found to be statistically significant (P < 0.01) at each of these frequencies. In calves tested during the first 24 hr after birth comparatively small responses were obtained.3. The hyperglycaemia produced by splanchnic nerve stimulation in older calves caused an abrupt rise in plasma insulin concentration when stimulation was discontinued but insulin release was completely inhibited throughout the period of stimulation at all frequencies tested.4. It is concluded that tonic changes in sympathetic efferent activity are likely to modify plasma glucagon concentration in the normal conscious calf.
Bloom SR, Polak JM, Pearse AG, 1973, Vasoactive intestinal peptide and watery-diarrhoea syndrome., Lancet, Vol: 2, Pages: 14-16, ISSN: 0140-6736
Bloom SR, Ogawa O, 1973, Radioimmunoassay of human peripheral plasma secretin., J Endocrinol, Vol: 58, Pages: xxiv-xxv, ISSN: 0022-0795
Johnston DI, Bloom SR, 1973, Plasma glucagon levels in the term human infant and effect of hypoxia., Arch Dis Child, Vol: 48, Pages: 451-454
The mean plasma pancreatic glucagon level at birth in 44 normal infants delivered vaginally was 140 pg/ml. The simultaneous maternal level was 122 pg/ml which was not quite significantly different at the P [unk]0.05 level. 2 hours after birth 30 of these infants had a mean rise in plasma glucagon of 51 pg/ml (P [unk] 0.01), and their mothers had a fall of 38 pg/ml (P [unk] 0.05). The mean plasma pancreatic glucagon level at birth in 12 normal infants delivered by caesarean section was 130 pg/ml which did not differ significantly from the group delivered vaginally. The glucagon level at birth in 20 infants with fetal distress (fetal scalp pH [unk] 7.2 or umbilical artery pH [unk] 7.15) was 244 pg/ml, and this was significantly higher than for normal infants at birth (P [unk] 0.01). Whereas the rise in neonatal glucagon 2 hours after birth might have been caused by a mean fall in blood glucose of 23 mg/100 ml, the infants with fetal distress had normal glucose levels, so that another mechanism must be responsible for their raised glucagon.
Thomson JP, Bloom SR, Haynes S, et al., 1973, Plasma enteroglucagon and plasma-volume changes after oral hypertonic glucose--their relationship to the dumping syndrome., Br J Surg, Vol: 60, ISSN: 0007-1323
Bloom S, 1973, Gut glucagon and reactive hypoglycaemia., Lancet, Vol: 1, ISSN: 0140-6736
POLAK JM, BLOOM SR, KUZIO M, et al., 1973, CELLULAR LOCALIZATION OF GASTRIC INHIBITORY POLYPEPTIDE IN DUODENUM AND JEJUNUM, GUT, Vol: 14, Pages: 284-288, ISSN: 0017-5749
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- Citations: 158
ZAPOL W, BERGER S, SALZMAN EW, et al., 1973, PLATELET DESTRUCTION DURING PROLONGED MEMBRANE LUNG PERFUSION, Publisher: WILLIAMS & WILKINS, Pages: 233-233, ISSN: 0009-7322
POLAK JM, HOFFBRAND AV, REED PI, et al., 1973, QUALITATIVE AND QUANTITATIVE STUDIES OF ANTRAL AND FUNDIC G-CELLS IN PERNICIOUS-ANEMIA, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, Vol: 8, Pages: 361-367, ISSN: 0036-5521
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- Citations: 68
Bloom SR, 1973, Glucagon, a stress hormone, Postgraduate Medical Journal, Vol: 49, Pages: 607-611, ISSN: 0032-5473
Glucagon is a catabolic hormone whose main immediate action is to raise blood glucose. In the healthy individual in a situation of stress an elevation of blood glucose above normal is advantageous and glucagon could be important in producing this. It has been shown that stimulation of the sympathetic nerves to the pancreas can cause a rapid and very large release of glucagon. Studies on baboons demonstrate that a similar pattern of very rapid release of glucagon occurs after pain or psychological stress. In man the elevated plasma glucagon noted in foetal distress, normal labor and fever may also be mediated by the sympathetic nervous system.
Bloom SR, Daniel PM, Johnston DI, et al., 1973, Release of glucagon, induced by stress., Q J Exp Physiol Cogn Med Sci, Vol: 58, Pages: 99-108, ISSN: 0033-5541
Vaughan NJ, Bloom SR, Ogawa O, et al., 1973, The role of the autonomic nervous system in the control of glucagon release during insulin hypoglycaemia in the calf., Experientia, Vol: 29, Pages: 805-806, ISSN: 0014-4754
Bloom SR, Royston CM, Thomson JP, 1972, Plasma enteroglucagon levels in the dumping syndrome., Clin Sci, Vol: 43, ISSN: 0009-9287
Bloom SR, Johnston DI, 1972, Failure of glucagon release in infants of diabetic mothers., Br Med J, Vol: 4, Pages: 453-454, ISSN: 0007-1447
Two hours after birth 30 normal infants had a fall in blood glucose of 20.6 mg/100 ml and a rise of plasma pancreatic glucagon of 50.7 pg/ml. Fifteen infants of diabetic mothers treated with insulin had a much greater fall in blood glucose of 77.5 mg/100 ml and a smaller rise of glucagon of 20.9 pg/ml. By comparison 14 small-for-dates infants, who are also prone to hypoglycaemia, had a blood glucose fall of 32.8 mg/100 ml and a larger rise of pancreatic glucagon of 96.0 pg/ml. It is suggested that the impaired pancreatic glucagon rise in the infants of diabetic mothers may be a significant factor in their hypoglycaemia.
Johnston DI, Bloom SR, Greene KR, et al., 1972, Plasma pancreatic glucagon relationship between mother and foetus at term., J Endocrinol, Vol: 55, Pages: xxv-xxvi, ISSN: 0022-0795
Bloom SR, Daniel PM, Johnston DI, et al., 1972, Changes in glucagon level associated with anxiety or stress., Psychol Med, Vol: 2, Pages: 426-427, ISSN: 0033-2917
Elias E, Polak JM, Bloom SR, et al., 1972, Pancreatic cholera due to production of gastric inhibitory polypeptide., Lancet, Vol: 2, Pages: 791-793, ISSN: 0140-6736
Bloom SR, Royston CM, Thomson JP, 1972, Enteroglucagon release in the dumping syndrome., Lancet, Vol: 2, Pages: 789-791, ISSN: 0140-6736
Johnston DI, Bloom SR, 1972, Study of immunoreactive pancreatic glucagon in the newborn period., Arch Dis Child, Vol: 47
Bloom SR, 1972, An enteroglucagon tumour., Gut, Vol: 13, Pages: 520-523, ISSN: 0017-5749
A hormone-secreting renal tumour that affected small bowel structure, motility, and function has been described by Gleeson et al (1971). The present studies show that the large amount of glucagon-like immunoreactivity which could be extracted from this tumour had the molecular weight, action on plasma insulin and glucose in vivo, and immunological reactions of the gut hormone enteroglucagon. This is the first enteroglucagonoma to be reported.
Bloom S, Millar JG, Nabarro JD, et al., 1972, Glucagon stimulation of the anterior pituitary., J Endocrinol, Vol: 53, ISSN: 0022-0795
Care AD, Bates RF, Bruce JB, et al., 1972, Stimulation of calcitonin secretion by gastro-intestinal hormones., J Endocrinol, Vol: 52, Pages: 27-28, ISSN: 0022-0795
Johnston DI, Bloom SR, Greene KR, et al., 1972, Failure of the human placenta to transfer pancreatic glucagon., Biol Neonate, Vol: 21, Pages: 375-380, ISSN: 0006-3126
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