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BALLESTA J, POLAK JM, HERNANDEZ J, et al., 1983, NPY LOCALIZATION AND DISTRIBUTION IN THE JUXTAGLOMERULAR APPARATUS, REGULATORY PEPTIDES, Vol: 7, Pages: 276-276, ISSN: 0167-0115
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- Citations: 3
BLOOM SR, CHRISTOFIDES ND, YIANGOU Y, et al., 1983, PEPTIDE HISTIDINE ISOLEUCINE (PHI) AND THE VERNER-MORRISON SYNDROME, GUT, Vol: 24, Pages: A473-A473, ISSN: 0017-5749
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- Citations: 4
TERENGHI G, BHUTTACHARJI S, GHATEI M, et al., 1983, SUBSTANCE-P-IMMUNOREACTIVE NERVES OF THE LUNG ORIGINATE FROM PRIMARY SENSORY NEURONS OF THE NODOSE GANGLION, JOURNAL OF PATHOLOGY, Vol: 139, Pages: 498-499, ISSN: 0022-3417
Svenberg T, Christofides ND, Fitzpatrick ML, et al., 1982, Interdigestive biliary output in man: relationship to fluctuations in plasma motilin and effect of atropine., Gut, Vol: 23, Pages: 1024-1028, ISSN: 0017-5749
The fasting output of bile into the bowel was investigated in nine healthy volunteers by hepatobiliary scanning. Subjects were studied twice, on each occasion for 2.5 hours. A significant flow of radioactivity from the gall bladder to the duodenum was observed on one or two occasions during each experiment. A 32 +/- 4% mean decrease in counts over the gall bladder was recorded, indicating partial emptying of this organ in the interdigestive state. The output of bile into the bowel was found to be related to fluctuations in fasting plasma motilin levels in that a significant motilin increment (18 +/- 4 pmol/l, p less than 0.005) paralleled the appearance of radioactivity in the duodenum. The onset of gall-bladder emptying regularly preceded the peak in plasma motilin (mean: 25 +/- 2 minutes). Atropine, intravenously, 0.6 mg followed by 0.3 mg, nearly abolished both fasting biliary output and plasma motilin fluctuations. Thus, bile output appears to occur frequently in fasting humans, but our data do not allow any conclusions as to the possible causal relationship between fasting gall-bladder emptying and release of motilin. Cholinergic influences appear to be of importance in the regulation of interdigestive biliary output in man.
Ghiglione M, Christofides ND, Yiangou Y, et al., 1982, PHI stimulates intestinal fluid secretion., Neuropeptides, Vol: 3, Pages: 79-82, ISSN: 0143-4179
Regulatory peptides are likely to have a role in the control of net intestinal fluid transport. PHI is a peptide recently isolated from porcine duodenum which has been shown to have sequence homologies with other peptides of the glucagon-secretin family. We have studied the effect of intravenous infusion of synthetic PHI on net intestinal fluid transport in the rat small intestine. During PHI infection net absorption was reduced in the duodenum and jejunum and net secretion was observed in the ileum. Thus synthetic PHI appears to be capable of strongly stimulating intestinal secretion in the rat.
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