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Bloom SR, Polak JM, 1982, Clinical aspects of gut hormones and neuropeptides., Br Med Bull, Vol: 38, Pages: 233-238, ISSN: 0007-1420
Solt J, Kádas I, Németh A, et al., 1982, [Apudoma of the stomach producing pancreatic polypeptide hormone]., Orv Hetil, Vol: 123, Pages: 2111-2115, ISSN: 0030-6002
Christofides ND, Arreola F, Svenberg T, et al., 1982, Chromatographic analysis of plasma motilin immunoreactivity in human disease using region specific antibodies., Clin Chim Acta, Vol: 123, Pages: 51-57, ISSN: 0009-8981
Greenberg GR, McCloy RF, Baron JH, et al., 1982, Gastric acid regulates the release of plasma secretin in man., Eur J Clin Invest, Vol: 12, Pages: 361-372, ISSN: 0014-2972
Fasting plasma secretin determined in nine healthy subjects, twelve patients with active duodenal ulcer and four with Zollinger-Ellison syndrome were 3.2 +/- 0.4, 5.1 +/- 1.2 and 20.3 +/- 1.3 pmol/l respectively (mean +/- SEM). Cimetidine significantly (P less than 0.05) reduced levels in those with duodenal ulcer, as did gastric aspiration in the Zollinger-Ellison group. A significant correlation (P less than 0.001) was found between basal acid output and mean fasting plasma secretin. After a solid meal and subsequent liquid soft drink, no sustained mean rise in plasma secretin was observed; changes in secretin appeared to coincide in time with rapid falls in duodenal pH, though little relationship could be established between the absolute level of pH and changes in plasma secretin. The mean peak post-prandial rise in plasma secretin observed after solids was significantly (P less than 0.05) greater in duodenal ulcer patients than controls (9.1 +/- 1.1 versus 6.7 +/- 0.5 pmol/l) as was the mean integrated post-prandial release (1002 +/- 110 versus 710 +/- 67 pmol min-1 1(-1)). Cimetidine reduced both rises (P less than 0.05) and was associated with significantly less duodenal pH readings below 4 (P less than 0.001). These results suggest that gastric acid is a major release mechanism for plasma secretin both fasting and after meals but it is likely the acid load rather than absolute pH in the duodenum which determines circulating levels.
Hall GM, Adrian TE, Bloom SR, et al., 1982, Changes in circulating gut hormones in the horse during long distance exercise., Equine Vet J, Vol: 14, Pages: 209-212, ISSN: 0425-1644
Venous blood samples were collected before and immediately after an 80 km ride and a 42 km race. They were analysed for blood glucose and lactate, and for plasma non-esterified fatty acids, insulin, pancreatic glucagon, pancreatic polypeptide, gastrin, gastric inhibitory peptide, somatostatin and vasoactive intestinal polypeptide concentrations. The 80 km ride was associated with marked hypoglycaemia and a slight lactic acidaemia together with an increase in plasma glucagon, somatostatin, pancreatic polypeptide and vasoactive intestinal polypeptide values. The 42 km race produced hyperglycaemia and marked lactic acidaemia together with an increase in plasma glucagon, somatostatin and vasoactive intestinal polypeptide. The increase in these peptides is not related to alterations in blood glucose or the relative contributions of aerobic and anaerobic muscle metabolism. It is suggested that the changes in circulating gut peptides are part of the endocrine response to exercise and the possible physiological role of these changes is discussed.
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