Publications
2554 results found
Dawson J, Bryant MG, Bloom SR, et al., 1982, The sedimentation coefficients of human jejunal gut hormone storage granules., Clin Chim Acta, Vol: 122, Pages: 47-50, ISSN: 0009-8981
Tischler AS, Lee YC, Slayton VW, et al., 1982, Content and release of neurotensin in PC12 pheochromocytoma cell cultures: modulation by dexamethasone and nerve growth factor., Regul Pept, Vol: 3, Pages: 415-421, ISSN: 0167-0115
The production of neurotensin-like immunoreactivity was investigated in cultured PC12 rat pheochromocytoma cells with and without the addition of nerve growth factor (NGF) and dexamethasone. Both monolayer cultures and spinner cultures contained measurable amounts of neurotensin. In the monolayer cultures supplemented with NGF and dexamethasone, cell and medium concentrations of neurotensin increased approx. 100-fold. In the spinner cultures the effect of the additives was less potent and the increase in neurotensin content, while still considerable, was approximately an order of magnitude less. Chromatographic analysis of medium and extracts of the cells from monolayer cultures indicated that the majority of the immunoreactivity coeluted in the same position as synthetic neurotensin, with recoveries of 68 and 85%, respectively. The effect of NGF and dexamethasone on neurotensin production differs significantly from their effect on catecholamine production in PC12 cells, and this suggests the possibility of independent regulation.
Nakanome C, Akai H, Umezu M, et al., 1982, [The effect of calcium on the release of gastric inhibitory polypeptide (GIP) - with reference to the release of GIP in patients with hyperparathyroidism (author's transl)]., Nihon Naibunpi Gakkai Zasshi, Vol: 58, Pages: 98-109, ISSN: 0029-0661
Plasma gastric inhibitory polypeptide (GIP), insulin, glucagon concentrations and blood glucose levels in response to the ingestion of 100 g glucose were measured in 5 patients with hyperparathyroidism in order to elucidate the effect of hypercalcemia on the release of these hormones. In addition, the effect of acute hypercalcemia on the release of these hormones in response to glucose ingestion was investigated in normal subjects. Fasting plasma GIP concentration in patients with hyperparathyroidism was significantly greater than the value in seventeen normal subjects. Significantly higher responses of plasma GIP and insulin were observed after the glucose ingestion in the patients with hyperparathyroidism as compared with the values in the normal subjects, and integrated GIP and insulin responses to the glucose ingestion for 120 min in the patients with hyperparathyroidism were significantly greater than the values in the normal subjects. On the other hand, plasma glucagon concentration after the glucose ingestion in the patients with hyperparathyroidism remained unchanged, although plasma glucagon concentrations after the glucose ingestion decreased significantly from the basal value in the normal subjects. Blood glucose levels after the glucose ingestion in two groups increased significantly from the basal value in the same manner. In nine normal subjects calcium infusion (4 mg/kg bolus injection followed by continuous infusion of 4 mg/kg/hr for 3 hr) caused a significantly high concentration of plasma calcium (11.5 approximately 13.0 mg/dl) from the basal value. Significantly higher responses of plasma GIP and insulin to the glucose ingestion were observed during calcium infusion as compared with the values during saline infusion. On the other hand, plasma glucagon concentration after the glucose ingestion was not significantly changed during calcium infusion in contrast with a significant decrease of plasma glucagon after the glucose ingestion during saline in
Bloom SR, Edwards AV, Ghatei MA, 1982, Bombesin: An important component in neural control of insulin release, Diabetologia, Vol: 23, ISSN: 0012-186X
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Christofides ND, Mallet E, Bloom SR, 1982, Plasma motilin in infantile pyloric stenosis, Biomedical Research, Vol: 3, Pages: 571-572, ISSN: 0388-6107
Plasma motilin concentrations were measured in 8 infants with confirmed idiopathic hypertrophic pyloric stenosis, at 30 days post-partum, and 7 age-matched controls. Plasma motilin concentrations were significantly lower in the pyloric stenosis group when compared to the controls.
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