Imperial College London
Alternate

Professor Sir Steve Bloom FMedSci, FRS

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Departmental Academic REF2014 Lead
 
 
 
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Contact

 

+44 (0)20 7594 9048s.bloom Website

 
 
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Assistant

 

Ms Keda Price-Cousins +44 (0)20 7594 9048

 
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Location

 

6N3Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Amin:2018:10.1002/oby.22323,
author = {Amin, A and Neophytou, C and Thein, S and Martin, N and Alamshah, SA and Spreckley, E and Bloom, S and Murphy, KG},
doi = {10.1002/oby.22323},
journal = {Obesity},
pages = {1721--1726},
title = {L-Arginine increases post-prandial circulating GLP-1 and PYY levels in humans},
url = {http://dx.doi.org/10.1002/oby.22323},
volume = {26},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveThe satiating effect of protein compared with other nutrients has been well described and is thought to be mediated, in part, by gut hormone release. Previously, it has been shown that oral Larginine acts as a GLP1 secretagogue both in vitro and in vivo in rodents. Here, the effect of Larginine on gut hormone release in humans was investigated.MethodsThe hypothesis was tested in two separate studies. The first study assessed the tolerability of oral Larginine in healthy human subjects. The second study assessed the effect of oral Larginine on gut hormone release following an ad libitum meal. Subjects were given Larginine, glycine (control amino acid), or vehicle control in a randomized doubleblind fashion.ResultsAt a dose of 17.1 mmol, Larginine was well tolerated and stimulated the release of plasma GLP1 (P < 0.05) and PYY (P < 0.001) following an ad libitum meal. Food diaries showed a trend toward lower energy intake and particularly fat intake following Larginine treatment.ConclusionsLarginine can significantly elevate GLP1 and PYY in healthy human volunteers in combination with a meal. Further work is required to investigate whether Larginine may have utility in the suppression of appetite and food intake.
AU  - Amin,A
AU  - Neophytou,C
AU  - Thein,S
AU  - Martin,N
AU  - Alamshah,SA
AU  - Spreckley,E
AU  - Bloom,S
AU  - Murphy,KG
DO  - 10.1002/oby.22323
EP  - 1726
PY  - 2018///
SN  - 1930-7381
SP  - 1721
TI  - L-Arginine increases post-prandial circulating GLP-1 and PYY levels in humans
T2  - Obesity
UR  - http://dx.doi.org/10.1002/oby.22323
UR  - http://hdl.handle.net/10044/1/63791
VL  - 26
ER  -
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