Imperial College London
Alternate

Professor Sir Steve Bloom FMedSci, FRS

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Departmental Academic REF2014 Lead
 
 
 
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Contact

 

+44 (0)20 7594 9048s.bloom Website

 
 
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Assistant

 

Ms Keda Price-Cousins +44 (0)20 7594 9048

 
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Location

 

6N3Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Comninos:2018:10.1172/jci.insight.121958,
author = {Comninos, A and Demetriou, L and Wall, M and Shah, A and Clarke, S and Narayanaswamy, S and Nesbitt, A and Izzi-Engbeaya, C and Prague, J and Abbara, A and Ratnasabapathy, R and Yang, LY and Salem, V and Nijher, G and Jayasena, C and Tanner, M and Bassett, P and Mehta, A and McGonigle, J and Rabiner, E and Bloom, S and Dhillo, W},
doi = {10.1172/jci.insight.121958},
journal = {JCI insight},
pages = {1--11},
title = {Modulations of human resting brain connectivity by Kisspeptin enhance sexual and emotional Functions},
url = {http://dx.doi.org/10.1172/jci.insight.121958},
volume = {3},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND. Resting brain connectivity is a crucial component of human behavior demonstrated by disruptions in psychosexual and emotional disorders. Kisspeptin, a recently identified critical reproductive hormone, can alter activity in certain brain structures but its effects on resting brain connectivity and networks in humans remain elusive.METHODS. We determined the effects of kisspeptin on resting brain connectivity (using functional neuroimaging) and behavior (using psychometric analyses) in healthy men, in a randomized double-blinded 2-way placebo-controlled study.RESULTS. Kisspeptin’s modulation of the default mode network (DMN) correlated with increased limbic activity in response to sexual stimuli (globus pallidus r = 0.500, P = 0.005; cingulate r = 0.475, P = 0.009). Furthermore, kisspeptin’s DMN modulation was greater in men with less reward drive (r = –0.489, P = 0.008) and predicted reduced sexual aversion (r = –0.499, P = 0.006), providing key functional significance. Kisspeptin also enhanced key mood connections including between the amygdala-cingulate, hippocampus-cingulate, and hippocampus–globus pallidus (all P < 0.05). Consistent with this, kisspeptin’s enhancement of hippocampus–globus pallidus connectivity predicted increased responses to negative stimuli in limbic structures (including the thalamus and cingulate [all P < 0.01]).CONCLUSION. Taken together, our data demonstrate a previously unknown role for kisspeptin in the modulation of functional brain connectivity and networks, integrating these with reproductive hormones and behaviors. Our findings that kisspeptin modulates resting brain connectivity to enhance sexual and emotional processing and decrease sexual aversion, provide foundation for kisspeptin-based therapies for associated disorders of body and mind.
AU  - Comninos,A
AU  - Demetriou,L
AU  - Wall,M
AU  - Shah,A
AU  - Clarke,S
AU  - Narayanaswamy,S
AU  - Nesbitt,A
AU  - Izzi-Engbeaya,C
AU  - Prague,J
AU  - Abbara,A
AU  - Ratnasabapathy,R
AU  - Yang,LY
AU  - Salem,V
AU  - Nijher,G
AU  - Jayasena,C
AU  - Tanner,M
AU  - Bassett,P
AU  - Mehta,A
AU  - McGonigle,J
AU  - Rabiner,E
AU  - Bloom,S
AU  - Dhillo,W
DO  - 10.1172/jci.insight.121958
EP  - 11
PY  - 2018///
SN  - 2379-3708
SP  - 1
TI  - Modulations of human resting brain connectivity by Kisspeptin enhance sexual and emotional Functions
T2  - JCI insight
UR  - http://dx.doi.org/10.1172/jci.insight.121958
UR  - https://insight.jci.org/articles/view/121958
UR  - http://hdl.handle.net/10044/1/63547
VL  - 3
ER  -
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