Imperial College London
Alternate

Professor Sir Steve Bloom FMedSci, FRS

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Departmental Academic REF2014 Lead
 
 
 
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Contact

 

+44 (0)20 7594 9048s.bloom Website

 
 
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Assistant

 

Ms Keda Price-Cousins +44 (0)20 7594 9048

 
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Location

 

6N3Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Müller:2019:10.1016/j.molmet.2019.09.010,
author = {Müller, TD and Finan, B and Bloom, SR and D'Alessio, D and Drucker, DJ and Flatt, PR and Fritsche, A and Gribble, F and Grill, HJ and Habener, JF and Holst, JJ and Langhans, W and Meier, JJ and Nauck, MA and Perez-Tilve, D and Pocai, A and Reimann, F and Sandoval, DA and Schwartz, TW and Seeley, RJ and Stemmer, K and Tang-Christensen, M and Woods, SC and DiMarchi, RD and Tschöp, MH},
doi = {10.1016/j.molmet.2019.09.010},
journal = {Molecular Metabolism},
pages = {72--130},
title = {Glucagon-like peptide 1 (GLP-1)},
url = {http://dx.doi.org/10.1016/j.molmet.2019.09.010},
volume = {30},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, and modulation of rodent β-cell proliferation. GLP-1 also has cardio- and neuroprotective effects, decreases inflammation and apoptosis, and has implications for learning and memory, reward behavior, and palatability. Biochemically modified for enhanced potency and sustained action, GLP-1 receptor agonists are successfully in clinical use for the treatment of type-2 diabetes, and several GLP-1-based pharmacotherapies are in clinical evaluation for the treatment of obesity.
AU  - Müller,TD
AU  - Finan,B
AU  - Bloom,SR
AU  - D'Alessio,D
AU  - Drucker,DJ
AU  - Flatt,PR
AU  - Fritsche,A
AU  - Gribble,F
AU  - Grill,HJ
AU  - Habener,JF
AU  - Holst,JJ
AU  - Langhans,W
AU  - Meier,JJ
AU  - Nauck,MA
AU  - Perez-Tilve,D
AU  - Pocai,A
AU  - Reimann,F
AU  - Sandoval,DA
AU  - Schwartz,TW
AU  - Seeley,RJ
AU  - Stemmer,K
AU  - Tang-Christensen,M
AU  - Woods,SC
AU  - DiMarchi,RD
AU  - Tschöp,MH
DO  - 10.1016/j.molmet.2019.09.010
EP  - 130
PY  - 2019///
SN  - 2212-8778
SP  - 72
TI  - Glucagon-like peptide 1 (GLP-1)
T2  - Molecular Metabolism
UR  - http://dx.doi.org/10.1016/j.molmet.2019.09.010
UR  - https://www.sciencedirect.com/science/article/pii/S2212877819309135?via%3Dihub
UR  - http://hdl.handle.net/10044/1/74273
VL  - 30
ER  -
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