Imperial College London
Alternate

ProfessorStephenBrickley

Faculty of Natural Sciences, Department of Life Sciences

Professor of Systems Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 7699s.brickley

 
 
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Location

 

402ASir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ye:2013:10.3389/fncir.2013.00203,
author = {Ye, Z and McGee, TP and Houston, C and Brickley, SG},
doi = {10.3389/fncir.2013.00203},
journal = {Frontiers in Neural Circuits},
pages = {1--8},
title = {The contribution of delta subunit-containing GABA(A) receptors to phasic and tonic conductance changes in cerebellum thalamus and neocortex},
url = {http://dx.doi.org/10.3389/fncir.2013.00203},
volume = {7},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We have made use of the δ subunit-selective allosteric modulator DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl benzamide) to assay the contribution of δ-GABAARs to tonic and phasic conductance changes in the cerebellum, thalamus and neocortex. In cerebellar granule cells, an enhancement of the tonic conductance was observed for DS2 and the orthosteric agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol). As expected, DS2 did not alter the properties of GABAA receptor-mediated inhibitory postsynaptic synaptic conductances (IPSCs) supporting a purely extrasynaptic role for δ-GABAARs in cerebellar granule cells. DS2 also enhanced the tonic conductance recorded from thalamic relay neurons of the visual thalamus with no alteration in IPSC properties. However, in addition to enhancing the tonic conductance DS2 also slowed the decay of IPSCs recorded from layer II/III neocortical neurons. A slowing of the IPSC decay also occurred in the presence of the voltage-gated sodium channel blocker TTX. Moreover, under conditions of reduced GABA release the ability of DS2 to enhance the tonic conductance was attenuated. These results indicate that δ-GABAARs can be activated following vesicular GABA release onto neocortical neurons and that the actions of DS2 on the tonic conductance may be influenced by the ambient GABA levels present in particular brain regions.
AU  - Ye,Z
AU  - McGee,TP
AU  - Houston,C
AU  - Brickley,SG
DO  - 10.3389/fncir.2013.00203
EP  - 8
PY  - 2013///
SN  - 1662-5110
SP  - 1
TI  - The contribution of delta subunit-containing GABA(A) receptors to phasic and tonic conductance changes in cerebellum thalamus and neocortex
T2  - Frontiers in Neural Circuits
UR  - http://dx.doi.org/10.3389/fncir.2013.00203
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000328753800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.frontiersin.org/articles/10.3389/fncir.2013.00203/full
UR  - http://hdl.handle.net/10044/1/100678
VL  - 7
ER  -
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