Publications
98 results found
Steventon GB, Mitchell SC, 2006, Non-classical drug metabolism enzymes: The curious case of phenylalanine 4-monooxygenase, LETTERS IN DRUG DESIGN & DISCOVERY, Vol: 3, Pages: 405-412, ISSN: 1570-1808
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- Citations: 8
Dumas M-E, Barton RH, Toye A, et al., 2006, Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice, Proc Natl Acad Sci, Vol: 103, Pages: 12511-12516, ISSN: 0027-8424
Steventon GB, Mitchell SC, 2006, The sulphoxidation of <i>S</i>-carboxymethyl-L-cysteine in COPD, EUROPEAN RESPIRATORY JOURNAL, Vol: 27, Pages: 865-866, ISSN: 0903-1936
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- Citations: 7
Steventon GB, Mitchell SC, 2006, Thiodiglycolic acid and dermatological reactions following <i>S</i>-carboxymethyl-L-cysteine administration, BRITISH JOURNAL OF DERMATOLOGY, Vol: 154, Pages: 386-387, ISSN: 0007-0963
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- Citations: 4
GBSteventon, SCMitchell, 2006, Efficacy of S-carboxymethyl-L-cysteine for otitis media with effusion, ENT - Ear, Nose and Throat Journal, Vol: 85, Pages: 140-141
SCMitchell, RLSmith, JRHarris, 2006, Trimethylaminuria: A non-infectious cause of vaginal odor., The Female Patient, Vol: 31, Pages: 10-15
Mitchell SC, Carmichael PL, 2005, Metabonomics and the endocrine system, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 244, Pages: 10-14, ISSN: 0303-7207
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- Citations: 5
BBoonyapiwat, PPanagopoulos, HJones, et al., 2005, Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine in HepG2 cells., Drug Metabolism and Drug Interactions, Vol: 21, Pages: 1-18, ISSN: 0792-5077
Roopnarinesingh ES, Steventon GB, Harris RM, et al., 2005, Induction of cysteine dioxygenase activity by oral administration of cysteine analogues to the rat: implications for drug efficacy and safety., Drug Metabol Drug Interact, Vol: 21, Pages: 75-86, ISSN: 0792-5077
One of the major steps in the oxidation of the sulphur-containing amino acid, L-cysteine, is the production of cysteine sulphinic acid, catalysed by the enzyme cysteine dioxygenase. This enzyme plays a key role in the intermediary metabolism of sulphur-containing compounds. The activity of this crucial enzyme is known to be influenced by sulphur-compound intake, being increased in animals fed an excess of L-cysteine or methionine. However, the affects on this enzyme of the chronic administration of drugs similar in structure to cysteine are unknown. This has now been investigated using the anti-rheumatic agent, D-penicillamine, and the mucoactive compound, S-carboxymethyl-L-cysteine. Repeated oral administration of these sulphur-containing drugs to male Wistar rats for five consecutive days led to a significant increase in hepatic cysteine dioxygenase activity. This increase in the production rate of cysteine sulphinic acid remained evident until returning to control levels four days after cessation of drug administration. These observations provide evidence that these two drugs interact with the intermediary biochemistry of sulphur compounds and may provide hitherto unappreciated insights into mechanisms by which therapeutic effects and adverse reactions may occur.
Mitchell SC, 2005, Trimethylaminuria (fish-odour syndrome) and oral malodour., Oral Dis, Vol: 11 Suppl 1, Pages: 10-13
A small but important percentage of oral malodour cases have an extra-oral aetiology and certain of these fall into the category of 'blood-borne halitosis'. Odoriferous substances generated within the body and transported to the lungs via the circulatory system may, if sufficiently volatile, leave with the exhaled air and impart a foetid odour to the breath. The aliphatic tertiary amine, trimethylamine, is such a volatile compound that is generated to excess in patients with a metabolic disorder known as trimethylaminuria (fish-odour syndrome). This article highlights this condition and draws attention to its potential role in the causation of recalcitrant oral malodour.
Kenyon S, Carmichael PL, Khalaque S, et al., 2004, The passage of trimethylamine across rat and human skin, FOOD AND CHEMICAL TOXICOLOGY, Vol: 42, Pages: 1619-1628, ISSN: 0278-6915
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- Citations: 14
Khan S, Mitchell SC, Steventon GB, 2004, Lack of congruence between cysteine dioxygenase activity and <i>S</i>-carboxymethyl-L-cysteine <i>S</i>-oxidation activity in rat cytosol, JOURNAL OF PHARMACY AND PHARMACOLOGY, Vol: 56, Pages: 993-1000, ISSN: 0022-3573
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- Citations: 7
Mitchell SC, Waring RH, 2004, Carboxanilide persistence in wildlife: excretion and retention in a rat model., Bull Environ Contam Toxicol, Vol: 72, Pages: 686-691, ISSN: 0007-4861
GBSteventon, AHGoreish, SBednar, et al., 2004, Phenylalanine hydoxylase and the S-oxidation of L-methionine in the rat., Journal of Inherited Metabolic Disease, Vol: 27 (Suppl 1), ISSN: 0141-8955
Roopnarinsingh ES, Steventon GB, Harris RM, et al., 2004, The effect of cysteine analogues on the excretion of urinary sulphate in the rat following cysteine administration., Drug Metabol Drug Interact, Vol: 20, Pages: 1-10, ISSN: 0792-5077
A major pathway for the production of sulphate within the mammalian body is known to be via the oxidative degradation of the sulphur moiety within the amino acid, L-cysteine. The ability of two structurally similar sulphur-containing drugs, the anti-rheumatic agent, D-penicillamine, and the mucoactive compound, S-carboxymethyl-L-cysteine, to interfere with this sulphate production was investigated. Co-administration to the male rat of D-penicillamine (p.o.) and S-carboxymethyl-L-cysteine (p.o.) with [35S]-L-cysteine (i.p.) led to a significant decrease in the subsequent urinary elimination of inorganic sulphate whilst having no measurable effect on organic sulphate excretion. The co-administration of L-valine, an amino acid not containing sulphur, had no effect. It is not known where, within the complex sequence of events surrounding the degradation of cysteine to sulphate, that D-penicillamine or S-carboxymethyl-L-cysteine may interact.
SCMitchell, PLCarmichael, RHWaring, 2004, The three conrnerstones of toxicology, Biologist, Vol: 51, Pages: 212-215, ISSN: 0006-3347
AHGoreish, SBednar, HJones, et al., 2004, Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine, Drug Metabolism and Drug Interactions, Vol: 20, Pages: 159-174, ISSN: 0792-5077
Waring RH, Harris RM, Steventon GB, et al., 2003, Degradation to sulphate of S-methyl-L-cysteine sulphoxide and S-carboxymethyl-L-cysteine sulphoxide in man., Drug Metabolism and Drug Interactions, Vol: 19, Pages: 241-255, ISSN: 0792-5077
Mitchell SC, Smith RL, 2003, Trimethylamine and odorous sweat, JOURNAL OF INHERITED METABOLIC DISEASE, Vol: 26, Pages: 415-416, ISSN: 0141-8955
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- Citations: 6
Mitchell SC, Carmichael PL, Waring RH, 2003, Aminophenols, Kirk-Othmer Encyclopedia of Chemical Technology, Publisher: John Wiley & Sons, New York
Cashman JR, Camp K, Fakharzadeh SS, et al., 2003, Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria., Current Drug Metabolism, Vol: 4, Pages: 151-170, ISSN: 1389-2002
Mitchell S, Holmes E, Carmichael P, 2002, Metabonomics and medicine: the Biochemical Oracle., Biologist (London), Vol: 49, Pages: 217-221, ISSN: 0006-3347
Occasionally, a new idea emerges that has the potential to revolutionize an entire field of scientific endeavour. It is now within our grasp to be able to detect subtle perturbations within the phenomenally complex biochemical matrix of living organisms. The discipline of metabonomics promises an all-encompassing approach to understanding total, yet fundamental, changes occurring in disease processes, drug toxicity and cell function.
Mitchell SC, Kestell P, Steventon GB, et al., 2002, Fate of the anthelmintic, phenothiazine, in man, XENOBIOTICA, Vol: 32, Pages: 771-782, ISSN: 0049-8254
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- Citations: 5
Mitchell S, Waring R, 2002, Who was.... William Veale Thorpe?, Biologist (London), Vol: 49, Pages: 131-132, ISSN: 0006-3347
William Veale Thorpe (1902-1988) was a gentleman and a scientist. His ceaseless energy, infectious enthusiasm and meticulous research established his group as pioneers, and himself as one of the architects of a new branch of science. The vast pharmaceutical industries of today owe much to the far-sighted research of Thorpe and his fellow investigators--a debt all too easily forgotten.
Mitchell SC, Zhang AQ, Smith RL, 2002, Chemical and biological liberation of trimethylamine from foods, JOURNAL OF FOOD COMPOSITION AND ANALYSIS, Vol: 15, Pages: 277-282, ISSN: 0889-1575
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- Citations: 22
b, 2002, Molecules of Death, London, Singapore, Publisher: World Scientific and Imperial College Press, ISBN: 9781860941276
SCMitchell, 2002, Phosphorus, Molecules of Death, Editors: Waring, Steventon, Mitchell, London, Singapore, Publisher: World Scientific and Imperial College Press, Pages: 182-196, ISBN: 9781860941276
Mitchell SC, Zhang AQ, 2001, Methylamine in human urine, CLINICA CHIMICA ACTA, Vol: 312, Pages: 107-114, ISSN: 0009-8981
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- Citations: 52
Bollard ME, Holmes E, Lindon JC, et al., 2001, Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution <SUP>1</SUP>H NMR spectroscopy of urine and pattern recognition, ANALYTICAL BIOCHEMISTRY, Vol: 295, Pages: 194-202, ISSN: 0003-2697
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- Citations: 156
Mitchell SC, Smith RL, 2001, Trimethylaminuria: The fish malodor syndrome, DRUG METABOLISM AND DISPOSITION, Vol: 29, Pages: 517-521, ISSN: 0090-9556
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- Citations: 156
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