Publications
97 results found
Mitchell SC, Zhang AQ, Smith RL, 2000, Ethylamine in human urine., Clin Chim Acta, Vol: 302, Pages: 69-78, ISSN: 0009-8981
The urinary excretion of ethylamine has been measured in 200 unrelated healthy volunteers (100 male, 100 female) who maintained their normal diet. The average daily output was 7.82+/-7.03 mg (mean+/-S.D.) (8.01+/-7.40 male; 7.64+/-6.67 female) with a range of values spreading from 0.22 to 35.27 mg. Dietary studies investigating 41 food substances did not highlight any major sources of this amine, except that drinking tea increased subsequent urinary ethylamine levels.
Mitchell SC, Nickson RM, Porter ER, et al., 2000, The fate of diphenyl sulphide, diphenyl sulphoxide and diphenyl sulphone in the rat., Drug Metabol Drug Interact, Vol: 16, Pages: 191-206, ISSN: 0792-5077
Radiolabelled [UL-14C]-diphenyl sulphide, [UL-14C]-diphenyl sulphoxide and [UL-14C]-diphenyl sulphone were administered by gavage (1.0 mmol/kg body weight) to adult male Wistar rats following an overnight fast. For all compounds, faeces were the major route of excretion of radioactivity (50%). Urinary elimination (40%) was similar during the first (19%) and second (16%) days and a small amount of radioactivity (6%) was found within the carcass after four days. From urinary and faecal data, metabolism occurred via ring hydroxylation with subsequent conjugate formation. Oxidation of the sulphur to form the sulphoxide and sulphone also took place; a small amount of sulphoxide reduction was apparent but no sulphone reduction was found. No evidence for exclusion of the sulphur was obtained, and it appeared unlikely that extensive cleavage of the ring structures occurred.
Mitchell SC, Zhang AQ, Noblet JMD, et al., 1997, Metabolic disposition of [C-14]-trimethylamine N-oxide in rat: variation with dose and route of administration, XENOBIOTICA, Vol: 27, Pages: 1187-1197, ISSN: 0049-8254
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- Citations: 20
Mitchell SC, 1994, The toxicity of phenothiazine., Drug Metabol Drug Interact, Vol: 11, Pages: 201-235, ISSN: 0792-5077
Phenothiazine, the parent compound of a multitude of present-day drugs, has been employed on an extensive scale for its insecticidal, fungicidal, antibacterial and anthelmintic properties. Almost a catholicon, its widespread use in animals and man has led to the uncovering of many adverse reactions encompassing effects on blood elements, neuromuscular problems and photosensitization. The high lipophilicity of phenothiazine and the formation of two redox systems amongst its many metabolites can facilitate the occurrence of generalised macromolecular disruption. Information from the literature has been garnered and appraised in this review to enable an insight into the possible mode(s) of interaction of phenothiazine with living systems.
AYESH R, MITCHELL SC, ZHANG A, et al., 1993, THE FISH ODOR SYNDROME - BIOCHEMICAL, FAMILIAL, AND CLINICAL ASPECTS, BRITISH MEDICAL JOURNAL, Vol: 307, Pages: 655-657, ISSN: 0959-8138
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- Citations: 112
HUNT PA, MITCHELL SC, WARING RH, 1982, SOME PROPERTIES OF SULFOXIDIZING ENZYMES, ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, Vol: 136, Pages: 1255-1262, ISSN: 0065-2598
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- Citations: 1
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