Imperial College London
Alternate

DrSubarnaChakravorty

Faculty of Medicine, Department of Immunology and Inflammation

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3299 3773s.chakravorty

 
 
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Location

 

Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Howard:2018:10.1186/s13063-017-2419-0,
author = {Howard, J and Slee, AE and Skene, S and Inusa, B and Kawadler, J and Downes, M and Gavlak, J and Koelbel, M and Stotesbury, H and Chorozoglou, M and Tebbs, S and Chakravorty, S and Awogbade, M and Rees, DC and Gupta, A and Murphy, PB and Hart, N and Sahota, S and Nwosu, C and Gwam, M and Saunders, D and Muthurangu, V and Barber, N and Ako, E and Thein, SL and Marshall, M and Reading, IC and Cheng, MYE and Kirkham, FJ and Liossi, C},
doi = {10.1186/s13063-017-2419-0},
journal = {Trials},
title = {Overnight auto-adjusting continuous airway pressure + standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): study protocol for a randomised controlled trial.},
url = {http://dx.doi.org/10.1186/s13063-017-2419-0},
volume = {19},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: In addition to pain, sickle cell anaemia (HbSS) complications include neurocognitive difficulties in attention and processing speed associated with low daytime and night-time oxygen saturation compounded by obstructive sleep apnoea (OSA). In the general population OSA is treated with continuous positive airways pressure (CPAP). The aim of this single-blind, randomised, controlled phase II trial is to compare auto-adjusting CPAP (APAP) with standard care to standard care alone in individuals with HbSS to determine whether the intervention improves attention and processing speed, brain structure, pain and quality of life. METHODS/DESIGN: Eligibility criteria include: ability to provide informed consent; age > 8 years; diagnosis of HbSS; and mean overnight saturation of < 90% for < 30% of the night (i.e. not meeting current criteria for overnight oxygen therapy). Key exclusion criteria are: overnight respiratory support; respiratory or decompensated cardiac failure; chronic transfusion; or contraindications to APAP therapy or magnetic resonance imaging (MRI). Sixty individuals with HbSS (30 children and 30 adults) will be randomised to standard care + APAP or standard care alone for six months. Minimisation factors are: age group (8-11, 12-15, 16-22 and > 23 years); silent infarction on MRI; minimum overnight oxygen saturation > 90% or < 90%; and hydroxyurea use. For APAP individuals, the intervention is administered at home. Adherence and effectiveness are recorded using software documenting hours of use each night and overnight oximetry. Participant support in terms of appropriate facemask and facilitating adherence are provided by an unblinded sleep physiologist. The primary outcome is change in the cancellation subtest from the Wechsler scales. Secondary outcomes include general cognitive functioning, quantitative brain MRI, bloo
AU  - Howard,J
AU  - Slee,AE
AU  - Skene,S
AU  - Inusa,B
AU  - Kawadler,J
AU  - Downes,M
AU  - Gavlak,J
AU  - Koelbel,M
AU  - Stotesbury,H
AU  - Chorozoglou,M
AU  - Tebbs,S
AU  - Chakravorty,S
AU  - Awogbade,M
AU  - Rees,DC
AU  - Gupta,A
AU  - Murphy,PB
AU  - Hart,N
AU  - Sahota,S
AU  - Nwosu,C
AU  - Gwam,M
AU  - Saunders,D
AU  - Muthurangu,V
AU  - Barber,N
AU  - Ako,E
AU  - Thein,SL
AU  - Marshall,M
AU  - Reading,IC
AU  - Cheng,MYE
AU  - Kirkham,FJ
AU  - Liossi,C
DO  - 10.1186/s13063-017-2419-0
PY  - 2018///
TI  - Overnight auto-adjusting continuous airway pressure + standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): study protocol for a randomised controlled trial.
T2  - Trials
UR  - http://dx.doi.org/10.1186/s13063-017-2419-0
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29357947
VL  - 19
ER  -
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