121 results found
De Matteis S, 2022, Occupational causes of chronic obstructive pulmonary disease: an update., Curr Opin Allergy Clin Immunol, Vol: 22, Pages: 73-79
PURPOSE OF REVIEW: This brief narrative review aims to highlight relevant recent updates on occupational causes of chronic obstructive pulmonary disease (COPD). RECENT FINDINGS: The most recent literature has been searched for any new relevant association between occupational exposures and COPD. Only large epidemiological studies of high quality have been included. Beyond the more traditional exposures, such as mineral or organic dusts, new chemicals have emerged as potential occupational causal agents for COPD. In particular, pesticides and cleaning products, including disinfectants, that have shown also positive exposure-response trends. For cleaning products, some specific chemicals have been identified, but for pesticides the identification of specific causal compounds is more challenging. The biological underlying mechanisms are still under study. SUMMARY: In the recent literature, occupational exposure to pesticides and cleaning products has emerged as potential cause of COPD. Awareness on occupational causes of COPD should increase among all stakeholders, from health professionals to public to prevent the associated public health burden. More studies on identifying the specific causal agents and mechanisms are needed to focus preventive strategies.
Nafees A, De Matteis S, Amaral A, et al., 2022, Impact of using different predictive equations on the prevalence of chronic byssinosis in textile workers in Pakistan, Occupational and Environmental Medicine, Vol: 79, Pages: 242-244, ISSN: 1351-0711
Objective Byssinosis remains a significant problem among textile workers in low/middle-income countries. Here we share our experience of using different prediction equations for assessing ‘chronic’ byssinosis according to the standard WHO classification using measurements of forced expiratory volume in 1 s (FEV1).Methods We enrolled 1910 workers in a randomised controlled trial of an intervention to improve the health of textile workers in Pakistan. We included in analyses the 1724 (90%) men who performed pre-bronchodilator spirometry tests of acceptable quality. We compared four different equations for deriving lung function percentage predicted values among those with symptoms-based byssinosis: the third US National Health and Nutrition Examination Survey (NHANES-III, with ‘North Indian and Pakistani’ conversion factor); the Global Lung Function Initiative (GLI, ‘other or mixed ethnicities’); a recent equation derived from survey of a western Indian population; and one based on an older and smaller survey of Karachi residents.Results 58 men (3.4%) had symptoms-based byssinosis according to WHO criteria. Of these, the proportions with a reduced FEV1 (<80% predicted) identified using NHANES and GLI; Indian and Pakistani reference equations were 40%, 41%, 14% and 12%, respectively. Much of this variation was eliminated when we substituted FEV1/forced vital capacity (FVC) ratio (<lower limit of normality) as a measure of airway obstruction.Conclusion Accurate measures of occupational disease frequency and distribution require approaches that are both standardised and meaningful. We should reconsider the WHO definition of ‘chronic’ byssinosis based on changes in FEV1, and instead use the FEV1/FVC.
Broccia G, Carter J, Ozsin-Ozler C, et al., 2022, Time trend and Bayesian mapping of multiple myeloma incidence in Sardinia, Italy (vol 12, 2736, 2022), SCIENTIFIC REPORTS, Vol: 12, ISSN: 2045-2322
Broccia G, Carter J, Ozsin-Ozler C, et al., 2022, Time trend and Bayesian mapping of multiple myeloma incidence in Sardinia, Italy, SCIENTIFIC REPORTS, Vol: 12, ISSN: 2045-2322
De Matteis S, Forastiere F, Baldacci S, et al., 2022, Issue 1 - "Update on adverse respiratory effects of outdoor air pollution". Part 1): Outdoor air pollution and respiratory diseases: A general update and an Italian perspective., Pulmonology
OBJECTIVE: to summarize the main updated evidence about the health effects of air pollution and to focus on Italian epidemiological experiences on the respiratory effects. RESULTS: The recent literature indicates that there is strong evidence for causal relationships between PM2.5 air pollution exposure and all-cause mortality as well as mortality from acute lower respiratory infections, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lung cancer. A growing body of evidence also suggests causal relationships with type II diabetes and impacts on neonatal mortality from low birth weight and short gestation as well as neurologic effects in both children and adults. Italy, a Southern European country, faces a more threatening air pollution challenge because of the effects of both anthropogenic pollutants and natural dust (particulate matter, PM). The 2020 Report of the European Environment Agency highlighted the number of premature deaths in Italy attributable to main pollutants: 52.300 for PM2.5, 10.400 for NO2 and 3.000 for O3 in 2018. In Italy, original time series and analytical epidemiological studies showed increased cardio-respiratory hospital admissions and mortality and increased risk of respiratory diseases in people living in urban areas. CONCLUSIONS: adverse health effects of air pollutants, even at low levels, have been confirmed by recent epidemiological studies. Further studies should focus on the potential link between air pollution exposure and respiratory infections. This topic has become particularly important in the current SARS-COV-2 pandemic. Based on strong scientific evidence, the Italian government, which hosts the Global Alliance against Chronic Respiratory Diseases (GARD)-Italy at the Ministry of Health, the scientific respiratory societies and the patients' associations, as well as others in the health sector and civil society, must increase their engagement in advocacy for clean air policies, especially in light o
Broccia G, Carter J, Ozsin-Ozler C, et al., 2022, Incidence of non-Hodgkin's lymphoma among adults in Sardinia, Italy, PLOS ONE, Vol: 17, ISSN: 1932-6203
De Matteis S, Jarvis D, Darnton L, et al., 2022, Lifetime occupational exposures and chronic obstructive pulmonary disease risk in the UK Biobank cohort, Thorax, ISSN: 0040-6376
BACKGROUND AND AIM: Occupational exposures are important, preventable causes of COPD. We previously found an increased risk of COPD among six occupations by analysing lifetime job histories and lung function data in the population-based UK Biobank cohort. We aimed to build on these findings and elucidate the underlying potential causal agents to focus preventive strategies. METHODS: We applied the ALOHA+job exposure matrix (JEM) based on the International Standard Classification of Occupations V.1988 codes, where exposure to 12 selected agents was rated as 0 (no exposure), 1 (low) or 2 (high). COPD was spirometrically defined as FEV1/FVC less than the lower limit of normal. We calculated semiquantitative cumulative exposure estimates for each agent by multiplying the duration of exposure and squared intensity. Prevalence ratio (PR) and 95% CI for COPD were estimated using robust Poisson regression adjusted for centre, sex, age, smoking and coexposure to JEM agents. Only associations confirmed among never-smokers and never-asthmatics were considered reliable. RESULTS: Out of 116 375 participants with complete job histories, 94 514 had acceptable/repeatable spirometry and smoking data and were included in the analysis. Pesticide exposure showed increased risk of COPD for ever exposure (PR=1.13, 95% CI 1.01 to 1.28) and high cumulative exposure (PR=1.32, 95% CI 1.12 to 1.56), with positive exposure-response trends (p trend=0.004), which were confirmed among never-smokers (p trend=0.005) and never-asthmatics (p trend=0.001). CONCLUSION: In a large population-based study, occupational exposure to pesticides was associated with risk of COPD. Focused preventive strategies for workers exposed to pesticides can prevent the associated COPD burden.
Nafees AA, De Matteis S, Burney P, et al., 2022, Contemporary prevalence of byssinosis in low- and middle-income countries: a systematic review, Asia-Pacific Journal of Public Health, Pages: 1-10, ISSN: 1010-5395
We aimed to identify the contemporary prevalence of byssinosis through a systematic review. We used Medline, Web of Science, Embase, and Global Health databases to identify studies published in any language between 2000 and 2019, reporting primary data on byssinosis among adults. We used the Joanna Briggs Institute checklist to estimate the risk of bias in studies and undertook a qualitative, narrative data analysis. The review considered the prevalence of byssinosis, chest tightness, and airflow obstruction in textile workers in low- and middle-income countries (LMICs). We found 26 relevant studies that included 6930 workers across 12 countries. Most of the studies (n = 19) were from Asia, and 7 from African countries. Twenty-five studies were cross-sectional surveys while 1 was a cohort study. The prevalence of byssinosis was reported by 18 studies, and ranged from 8% to 38%, without any clear associations, at the group level, between the prevalence of byssinosis and durations of workers’ exposures. Prevalence of chest tightness ranged between 4% and 58% and that of airflow obstruction between 10% and 30%. We found a strong correlation (r = 0.72) between prevalence of byssinosis and cotton dust levels. Our findings indicate that byssinosis remains a significant, contemporary problem in some parts of the textile sector in LMICs.
Cocco P, Piro S, Meloni F, et al., 2022, Night shift work and lymphoma: results from an Italian multicentre case-control study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, ISSN: 1351-0711
Veronesi G, De Matteis S, Calori G, et al., 2022, Long-term exposure to air pollution and COVID-19 incidence: a prospective study of residents in the city of Varese, Northern Italy, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 79, Pages: 192-199, ISSN: 1351-0711
Andersen ZJ, Gehring U, De Matteis S, et al., 2021, Clean air for healthy lungs - an urgent call to action: European Respiratory Society position on the launch of the WHO 2021 Air Quality Guidelines, EUROPEAN RESPIRATORY JOURNAL, Vol: 58, ISSN: 0903-1936
Nafees AA, Iqbal AR, Cullinan P, et al., 2021, Use of low-cost particle counters for cotton dust exposure assessment in textile mills in low- and middle-income countries, Annals of Work Exposures and Health, Vol: 66, ISSN: 2398-7308
OBJECTIVE: There is a lack of consensus on methods for cotton dust measurement in the textile industry, and techniques vary between countries-relying mostly on cumbersome, traditional approaches. We undertook comparisons of standard, gravimetric methods with low-cost optical particle counters for personal and area dust measurements in textile mills in Pakistan. METHODS: We included male textile workers from the weaving sections of seven cotton mills in Karachi. We used the Institute of Occupational Medicine (IOM) sampler with a Casella Apex 2 standard pump and the Purple Air (PA-II-SD) for measuring personal exposures to inhalable airborne particles (n = 31). We used the Dylos DC1700 particle counter, in addition to the two above, for area-level measurements (n = 29). RESULTS: There were no significant correlations between the IOM and PA for personal dust measurements using the original (r = -0.15, P = 0.4) or log-transformed data (r = -0.32, P = 0.07). Similarly, there were no significant correlations when comparing the IOM with either of the particle counters (PA and Dylos) for area dust measurements, using the original (r = -0.07, P = 0.7; r = 0.10, P = 0.6) or log-transformed data (r = -0.09, P = 0.6; r = 0.07, P = 0.7). CONCLUSION: Our findings show a lack of correlation between the gravimetric method and the use of particle counters in both personal and area measurements of cotton dust, precluding their use for measuring occupational exposures to airborne dust in textile mills. There continues to be a need to develop low-cost instruments to help textile industries in low- and middle-income countries to perform cotton dust exposure assessment.
Lecca R, Puligheddu M, Acar GM, et al., 2021, Shift rotation scheme, sleepiness and sleep quality in night-shift workers, OCCUPATIONAL MEDICINE-OXFORD, Vol: 71, Pages: 446-452, ISSN: 0962-7480
Andersen ZJ, Hoffmann B, Morawska L, et al., 2021, Air pollution and COVID-19: clearing the air and charting a post-pandemic course: a joint workshop report of ERS, ISEE, HEI and WHO, EUROPEAN RESPIRATORY JOURNAL, Vol: 58, ISSN: 0903-1936
Archangelidi O, Sathiyajit S, Consonni D, et al., 2021, Cleaning products and respiratory health outcomes in occupational cleaners: a systematic review and meta-analysis, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 78, Pages: 604-617, ISSN: 1351-0711
Consonni D, De Matteis S, 2021, Effectiveness of COVID-19 vaccination among healthcare workers, EPIDEMIOLOGIA & PREVENZIONE, Vol: 45, Pages: 310-311, ISSN: 1120-9763
Ratanachina J, Amaral A, De Matteis S, et al., 2021, Farming, pesticide exposure and respiratory health: a cross-sectional study in Thailand, Occupational and Environmental Medicine, Vol: 79, ISSN: 1351-0711
Objective: To assess the association of lung function and respiratory symptoms with farming, particularly pesticide use, in an agricultural province in Thailand.Methods: We undertook a cross-sectional survey of adults aged 40–65 in Nan province, Thailand, between May and August 2019. We randomly recruited 345 villagers and enriched the sample with 82 government employees. All participants performed post-bronchodilator spirometry and completed a questionnaire covering information on respiratory symptoms, farming activities, pesticide use and known risk factors for respiratory disease. Associations of respiratory outcomes with farming and pesticide exposures were examined by multivariable regression analysis.Results: The response rate was 94%. The prevalence of chronic airflow obstruction among villagers was 5.5%. Villagers had, on average, a lower percent predicted post-bronchodilator forced expiratory volume in one second/forced vital capacity (FEV1/FVC) than government employees (98.3% vs 100.3%; p=0.04). There was no evidence of association of lung function with farming activities, the use of specific herbicides (glyphosate and paraquat), insecticides (organophosphates and pyrethroids) or fungicides. The exceptions were poultry farming, associated with chronic cough and an increase of FEV1/FVC, and atrazine, for which duration (p-trend <0.01), intensity (p-trend <0.01) and cumulative hours (p-trend=0.01) of use were all associated with higher FEV1/FVC in an exposure–response manner. Cumulative hours (−280 mL/hour), low duration (−270 mL/year) and intensity (−270 mL/hour/year) of atrazine use were associated with lower FVC.Conclusions: Chronic airflow obstruction is uncommon among villagers of an agricultural province in Nan, Thailand. Farming and pesticide use are unlikely to be major causes of respiratory problems there.
De Matteis S, 2021, COVID-19: are not all workers 'essential'?, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 78, Pages: 305-306, ISSN: 1351-0711
Meloni F, Satta G, Padoan M, et al., 2021, Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study, ENVIRONMENTAL HEALTH, Vol: 20
Cocco P, Meloni F, Coratza A, et al., 2021, Vaccination against seasonal influenza and socio-economic and environmental factors as determinants of the geographic variation of COVID-19 incidence and mortality in the Italian elderly, PREVENTIVE MEDICINE, Vol: 143, ISSN: 0091-7435
Ratanachina J, Amaral AFS, De Matteis S, et al., 2021, OCCUPATIONAL EXPOSURES AND RESPIRATORY HEALTH: THE BURDEN OF OBSTRUCTIVE LUNG DISEASE (BOLD) STUDY RESULTS, Publisher: BMJ PUBLISHING GROUP, Pages: A2-A2, ISSN: 0040-6376
De Matteis S, Pira E, Mutti A, 2021, The COVID-19 pandemic and Occupational Medicine: impact and opportunities, MEDICINA DEL LAVORO, Vol: 112, Pages: 411-413, ISSN: 0025-7818
Cocco P, Satta G, Meloni F, et al., 2021, Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study, SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, Vol: 47, Pages: 42-51, ISSN: 0355-3140
De Matteis S, Ronsmans S, Nemery B, 2020, Respiratory Health Effects of Exposure to Cleaning Products, CLINICS IN CHEST MEDICINE, Vol: 41, Pages: 641-+, ISSN: 0272-5231
Meloni F, Satta G, Padoan M, et al., 2020, Occupational Exposure to Glyphosate and Risk of Lymphoma: Results of an Italian Multicenter Case-Control Study
<jats:title>Abstract</jats:title> <jats:p>BackgroundThe International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into the association between occupational exposure to glyphosate and risk of lymphoma subtypes in a multicenter case-control study conducted in Italy. MethodsThe Italian Gene-Environment Interactions in Lymphoma Etiology (ItGxE) study took place in 2011-17 in six Italian centres. Overall, 867 incident lymphoma cases and 774 controls participated in the study. Based on detailed questionnaire information, occupational experts classified duration, confidence, frequency, and intensity of exposure to glyphosate for each study subject. Using unconditional regression analysis, we modelled risk of major lymphoma subtypes associated with exposure to glyphosate adjusted by age, gender, education, and study centre. ResultsVery few study subjects (2.2%) were classified as ever exposed to glyphosate. Risk of follicular lymphoma (FL) was elevated 7-fold in subjects classified as ever exposed to glyphosate with medium-high confidence, 4.5-fold in association with medium-high cumulative exposure level, 12-fold with medium-high exposure intensity, and 6-fold with exposure for 10 days or more per year. Significant upward trends were detected with all the exposure metrics, but duration. The overall p-value for an upward trend with four independent metrics was 1.88 x 10<jats:sup>-4</jats:sup>. There was no association with risk of lymphoma (any subtype), Non Hodgkin Lymphoma, B-cell lymphoma, or the major lymphoma subtypes other than FL. ConclusionsOur findings provide limited support to the IARC decision to classify glyphosate as Group 2A human carcinogen.</jats:p>
van der Plaat DA, De Matteis S, Sadhra S, et al., 2020, Interaction between occupational exposures and antioxidant geneson chronic obstructive pulmonary disease in UK Biobank, ERS, Publisher: European Medical Group LTD, Pages: 77-78, ISSN: 2054-3166
Ratanachina J, Amaral A, De Matteis S, et al., 2020, Farming and respiratory health: a cross-sectional study in Thailand, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Fishwick D, Thompson E, Heederik D, et al., 2020, Using digital and social media to highlight the risks of occupational exposures as a cause of lung diseases, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
van der Plaat D, De Matteis S, Sadhra S, et al., 2020, Interaction between VGDF exposure and antioxidant genes on COPD in UK Biobank, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
De Matteis S, Consonni D, 2020, COVID-19 and healthcare workers, EPIDEMIOLOGIA & PREVENZIONE, Vol: 44, Pages: 340-342, ISSN: 1120-9763
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