Publications
139 results found
Park MH, Skow Á, De Matteis S, et al., 2015, Adiposity and carotid-intima media thickness in children and adolescents: a systematic review., BMC Pediatrics, Vol: 15, ISSN: 1471-2431
BACKGROUND: Adiposity in childhood is associated with later cardiovascular disease (CVD), but it is unclear whether this relationship is independent of other risk factors experienced in later life, such as smoking and hypertension. Carotid-intima media thickness (cIMT) is a measure of subclinical atherosclerosis that may be used to assess CVD risk in young people. The aim of this study was to examine the relationship between adiposity and cIMT in children and adolescents. METHODS: We searched Medline, Embase, Global Health, and CINAHL Plus electronic databases (1980-2014). Population-based observational studies that reported a measure of association between objectively-measured adiposity and cIMT in childhood were included in this review. RESULTS: Twenty-two cross-sectional studies were included (n = 7,366 children and adolescents). Thirteen of nineteen studies conducted in adolescent populations (mean age ≥12 years, n = 5,986) reported positive associations between cIMT and adiposity measures (correlation coefficients 0.13 to 0.59). Three studies of pre-adolescent populations (n = 1,380) reported mixed evidence, two studies finding no evidence of a correlation, and one an inverse relationship between skinfolds and cIMT. Included studies did not report an adiposity threshold for subclinical atherosclerosis. CONCLUSIONS: Based on studies conducted mostly in Western Europe and the US, adiposity does not appear to be associated with cIMT in pre-adolescents, but may be associated in adolescents. If further studies confirm these findings, a focus on cardiovascular disease prevention efforts in pre-adolescence, before arterial changes have emerged, may be justified.
De Matteis S, Jarvis D, Hutchings S, et al., 2015, Work-related COPD risk in the population-based UK Biobank cohort study, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
De Matteis S, Iridoy A, Cullinan P, 2015, A new spirometry-based algorithm to predict occupational pulmonary restrictive impairment, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
De Matteis S, Jarvis D, Wheatley M, et al., 2015, A new web-based tool to collect and code lifetime job-histories in large populationbased studies, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
De Matteis S, Cullinan, Paul, 2015, Occupational asthma in cleaners: a challenging black box., Occupational and Environmental Medicine, Vol: 72, Pages: 755-756, ISSN: 1470-7926
De Matteis S, Jarvis D, Wheatley M, et al., 2014, A New, Efficient Web-based Tool To Collect And Code Lifetime Job Histories In Large Population-based Studies: The Copd Project In The Uk Biobank Cohort, British Thoracic Society Winter Meeting 2014, Publisher: BMJ Publishing Group, Pages: A4-A4, ISSN: 1468-3296
De Matteis S, Iridoy AA, Cullinan P, 2014, A New, Efficient Spirometry-based Algorithm To Predict Restrictive Lung Disease In Workplace Respiratory Surveillance, British Thoracic Society Winter Meeting 2014, Publisher: BMJ Publishing Group, Pages: A135-A135, ISSN: 1468-3296
Sadhra S, Fishwick D, Kurmi OP, et al., 2014, DEVELOPMENT OF A JOB EXPOSURE MATRIX FOR SOC 2000 LISTINGS TO IDENTIFY OCCUPATIONAL CAUSES OF COPD, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A4-A4, ISSN: 0040-6376
Mensi C, Riboldi L, De Matteis S, et al., 2014, Impact of an asbestos cement factory on mesothelioma incidence: Global assessment of effects of occupational, familial, and environmental exposure, Environment International, Vol: 74, Pages: 191-199, ISSN: 1873-6750
Few studies have examined the incidence of malignant mesothelioma (MM) associated with distinct sources of asbestos exposure (occupational, familial, or environmental). We assessed the impact of asbestos exposure—global and by source—on the incidence of MM in Broni, an Italian town in which an asbestos cement factory once operated (1932–1993). Based on data collected by the Lombardy Mesothelioma Registry, we calculated the number of observed and expected MM cases among workers, their cohabitants, and people living in the area in 2000–2011. We identified 147 MM cases (17.45 expected), 138 pleural and nine peritoneal, attributable to exposure to asbestos from the factory. Thirty-eight cases had past occupational exposure at the factory (2.33 expected), numbering 32 men (26 pleural, six peritoneal) and six women (four pleural, two peritoneal). In the families of the workers, there were 37 MM cases (4.23 expected), numbering five men (all pleural) and 32 women (31 pleural, one peritoneal). Among residents in Broni or in the adjacent/surrounding towns, there were 72 cases of pleural MM (10.89 expected), numbering 23 men and 49 women. The largest MM excess was found in the towns of Broni (48 observed, 3.68 expected) and Stradella (16 observed, 1.85 expected). This study documents the large impact of the asbestos cement factory, with about 130 excess MM cases in a 12-year period. The largest MM burden was among women, from non-occupational exposure. Almost half of the MM cases were attributable to environmental exposure.
Denholm R, Schuez J, Straif K, et al., 2014, Is previous respiratory disease a risk factor for lung cancer?, American Journal of Respiratory and Critical Care Medicine, Vol: 190, Pages: 549-559, ISSN: 1535-4970
Rationale: Previous respiratory diseases have been associated with increased risk of lung cancer. Respiratory conditions often co-occur and few studies have investigated multiple conditions simultaneously.Objectives: Investigate lung cancer risk associated with chronic bronchitis, emphysema, tuberculosis, pneumonia, and asthma.Methods: The SYNERGY project pooled information on previous respiratory diseases from 12,739 case subjects and 14,945 control subjects from 7 case–control studies conducted in Europe and Canada. Multivariate logistic regression models were used to investigate the relationship between individual diseases adjusting for co-occurring conditions, and patterns of respiratory disease diagnoses and lung cancer. Analyses were stratified by sex, and adjusted for age, center, ever-employed in a high-risk occupation, education, smoking status, cigarette pack-years, and time since quitting smoking.Measurements and Main Results: Chronic bronchitis and emphysema were positively associated with lung cancer, after accounting for other respiratory diseases and smoking (e.g., in men: odds ratio [OR], 1.33; 95% confidence interval [CI], 1.20–1.48 and OR, 1.50; 95% CI, 1.21–1.87, respectively). A positive relationship was observed between lung cancer and pneumonia diagnosed 2 years or less before lung cancer (OR, 3.31; 95% CI, 2.33–4.70 for men), but not longer. Co-occurrence of chronic bronchitis and emphysema and/or pneumonia had a stronger positive association with lung cancer than chronic bronchitis “only.” Asthma had an inverse association with lung cancer, the association being stronger with an asthma diagnosis 5 years or more before lung cancer compared with shorter.Conclusions: Findings from this large international case–control consortium indicate that after accounting for co-occurring respiratory diseases, chronic bronchitis and emphysema continue to have a positive association with lung cancer.
Cortese B, De Carlo M, De Matteis S, et al., 2014, Distal embolisation during carotid stenting is predicted by circulating levels of LDL cholesterol and C-reactive protein, EUROINTERVENTION, Vol: 10, Pages: 513-517, ISSN: 1774-024X
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- Citations: 2
Consonni D, De Matteis S, Olsson A, et al., 2014, 0205 Lung cancer risk among bricklayers in a pooled analysis of case-control studies., Occup Environ Med, Vol: 71 Suppl 1
OBJECTIVES: Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies reported an excess of lung cancer among these workers. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case-control studies on lung cancer and the joint effects of occupational carcinogens (http://SYNERGY.iarc.fr). METHOD: The pooled dataset included 15 608 cases and 18 531 controls from 22 centres in Europe, Canada, Hong Kong, and New Zealand. For men ever employed as bricklayers we estimated odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for study centre, age, lifetime cigarette smoking history, and employment in occupations with exposures to known or suspected lung carcinogens. RESULTS: We found 1322 cases and 1004 controls who had ever worked as bricklayers (OR: 1.35; 95% CI: 1.22-1.49). There was a clear positive trend with length of employment (P < 0.0001). The relative risk was higher for squamous (OR: 1.44, 95% CI: 1.28-1.63, 578 cases) and small cell carcinomas (OR: 1.60, 95% CI: 1.36-1.87, 248 cases), than for adenocarcinoma (OR: 1.14, 95% CI: 0.98-1.32, 289 cases) (P-value for homogeneity: 0.0007). ORs were still elevated after additional adjustment for education and in analyses using blue collar workers as referents. CONCLUSIONS: This study provided additional evidence of increased lung cancer risk in bricklayers. Although non-causal explanations cannot be completely ruled out, the association is plausible in view of the potential for exposure to several carcinogens, notably crystalline silica and to a lesser extent asbestos.
De Matteis S, Rotunno M, Yu K, et al., 2014, 0259 Interaction between genetic and occupational factors in lung cancer aetiology. A population-based case-control study0259 Interaction between genetic and occupational factors in lung cancer aetiology. A population-based case-control study., Occup Environ Med, Vol: 71 Suppl 1
OBJECTIVES: Genetic susceptibility in work-related lung cancer aetiology could have an important public health impact. Few studies have previously evaluated this issue, with inconsistent results. We aimed to investigate interactions between exposure to occupational carcinogens and genetic polymorphisms in lung cancer aetiology, adopting a systematic integrated approach. METHOD: EAGLE, a population-based case-control study, enrolled 2100 lung cancer cases and 2120 controls (Italy, 2002-2005). Lifetime work histories were collected for 4059 subjects and translated into exposure to six occupational carcinogens (asbestos, silica, polycyclic aromatic hydrocarbons, diesel exhausts, chromium, and nickel) using a job-exposure matrix. We selected 23 candidate genes among phase II metabolic genes reported in association with lung cancer susceptibility and/or metabolism of selected carcinogens. 298 tagging single nucleotide polymorphisms (SNPs) were genotyped on 4050 subjects. We tested for interaction within smoking-adjusted logistic regressions where SNPs were modelled individually, by gene group (using gene scores and haplotypes), and by pathways. False discovery rate (FDR) was used to account for multiple testing. Gene expression changes in lung tissues were studied for SNPs-carcinogens significant interactions. RESULTS: As asbestos had the highest impact on lung cancer burden, we restricted interaction tests to this carcinogen. GSTM4 polymorphisms consistently showed positive interactions across different analysis levels, especially by SNP group score (FDR-adjusted p-value for interaction < 0.0001). No significant genetic "signal" by asbestos exposure was found at lung tissue level. CONCLUSIONS: GSTM4 polymorphisms may play a role in asbestos-related lung cancer aetiology. These findings are biologically plausible and have never previously been reported; they should therefore be validated in further studies.
De Matteis S, Rushton L, Jarvis D, et al., 2014, 0154 A new, efficient web-based tool to collect and code lifetime job histories in large population-based studies: the COPD project in the UK Biobank cohort.
OBJECTIVES: The manual collection and coding of job histories is the standard method for assessing occupational exposure, but may be infeasible for large population-based studies such as the UK Biobank cohort. We aimed to develop a new web-based tool to automatically collect and code individual lifetime job histories in the UK Biobank cohort for investigating the causes and burden of work-related COPD in the UK. METHOD: UK Biobank is a population-based cohort of 502 682 subjects, aged 40-69 years, recruited in 2006-2010. Baseline spirometry data, current employment and smoking histories were collected. We developed a job questionnaire based on the hierarchical structure of the standard occupational classification (SOC) 2000 to allow participants to automatically self-collect and code their lifetime job histories. The web-based prototype (www.imperial.ac.uk/biobank/questionnaire) was pre-piloted in May-August 2013 among key job sectors using snowball sampling together with a feedback survey. RESULTS: 171 subjects participated in both the pre-piloting and feedback survey. 91% completed the questionnaire in <20 min, 85% considered the instructions clear, and 80% found their job categories/titles easily. Overall, 96% judged the questionnaire to be clear and easy. A revised questionnaire has now been designed and will be accessible from different media including PCs/laptops, tablets and smart phones to encourage high response. A demonstration version will be made available to conference participants. CONCLUSIONS: Our web-based job questionnaire is an efficient new standard tool for collecting and automatically coding lifetime job histories in large population-based studies and is adaptable for use in many occupational health research projects.
Hutchings S, Ayres J, Cullinan P, et al., 2014, 0148 Using the UK Biobank study to estimate occupational causes of chronic disease: comparability with the UK national population and adjustment for bias.
OBJECTIVES: The UK Biobank study is a sample of 502,682 people aged 40-70, clustered around 22 assessment centres. As part of a project to investigate the causes of COPD and estimate the UK occupational burden, we have assessed the sample's representativeness with respect to the UK national population, with a view to accounting for potential biases. METHOD: We have compared characteristics of the Biobank population (age, education, employment, smoking etc) to that of the UK population as estimated from national data sources. RESULTS: Deprivation index scores indicate that Biobank respondents in more affluent wards are over-represented (52% of Biobank respondents versus 28% nationally have scores of less than -2). The Biobank respondents are also better-educated (33% to degree level, 17% nationally), with similar qualification levels in men and women, whereas more men than women nationally in this age range had higher level qualifications. Fewer were currently employed than nationally (58% vs. 65%), particularly men over 60, with more retired (45% vs. 33%), and fewer disabled or unemployed. There are more in managerial and professional (54% vs. 46%), and fewer in routine and manual occupations (22%, 33% nationally), and fewer smokers (33% vs. 49%). Fewer in the already under-represented unskilled occupations (47% vs. 70% for other occupations), or with reported respiratory ill-health (50% vs. 59%) have a usable email address. CONCLUSIONS: As Biobank respondents are on average less deprived, better educated and under-represented in unskilled occupations than the national population, estimating national occupational COPD burden, and collecting further data without bias will require data adjustments.
Gu F, Wacholder S, Kovalchik S, et al., 2014, Time to Smoke First Morning Cigarette and Lung Cancer in a Case-Control Study, JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol: 106, ISSN: 0027-8874
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- Citations: 18
Consonni D, De Matteis S, Pesatori AC, et al., 2014, Lung cancer risk among bricklayers in a pooled analysis of case-control studies, International Journal of Cancer, Vol: 136, Pages: 360-371, ISSN: 1097-0215
Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analyzedlung cancer risk among these workers had several study design limitations. We examined lung cancer risk amongbricklayers within SYNERGY, a large international pooled analysis of case–control studies on lung cancer and the joint effectsof occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95% confidence intervals(CI) adjusted for study center, age, lifetime smoking history and employment in occupations with exposures to known orsuspected lung carcinogens. Among 15,608 cases and 18,531 controls, there were 695 cases and 469 controls who had everworked as bricklayers (OR: 1.47; 95% CI: 1.28–1.68). In studies using population controls the OR was 1.55 (95% CI: 1.32–1.81, 540/349 cases/controls), while it was 1.24 (95% CI: 0.93–1.64, 155/120 cases/controls) in hospital-based studies.There was a clear positive trend with length of employment (p < 0.001). The relative risk was higher for squamous (OR: 1.68,95% CI: 1.42–1.98, 309 cases) and small cell carcinomas (OR: 1.78, 95% CI: 1.44–2.20, 140 cases), than for adenocarcinoma(OR: 1.17, 95% CI: 0.95–1.43, 150 cases) (p-homogeneity: 0.0007). ORs were still elevated after additional adjustment foreducation and in analyses using blue collar workers as referents. This study provided robust evidence of increased lung cancerrisk in bricklayers. Although non-causal explanations cannot be completely ruled out, the association is plausible in viewof the potential for exposure to several carcinogens, notably crystalline silica and to a lesser extent asbestos.
De Matteis S, Consonni D, Lubin JH, et al., 2013, Impact of occupational carcinogens on lung cancer risk in a general population (vol 41, pg 711, 2012), INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 42, Pages: 1902-1902, ISSN: 0300-5771
De Matteis S, Consonni D, Lubin JH, et al., 2013, Authors' Response to: Comment upon the article: Impact of occupational carcinogens on lung cancer risk in a general population, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 42, Pages: 1895-1896, ISSN: 0300-5771
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- Citations: 1
Kovalchik SA, De Matteis S, Landi MT, et al., 2013, A regression model for risk difference estimation in population-based case-control studies clarifies gender differences in lung cancer risk of smokers and never smokers., BMC Medical Research Methodology, Vol: 13, ISSN: 1471-2288
BACKGROUND: Additive risk models are necessary for understanding the joint effects of exposures on individual and population disease risk. Yet technical challenges have limited the consideration of additive risk models in case-control studies. METHODS: Using a flexible risk regression model that allows additive and multiplicative components to estimate absolute risks and risk differences, we report a new analysis of data from the population-based case-control Environment And Genetics in Lung cancer Etiology study, conducted in Northern Italy between 2002-2005. The analysis provides estimates of the gender-specific absolute risk (cumulative risk) for non-smoking- and smoking-associated lung cancer, adjusted for demographic, occupational, and smoking history variables. RESULTS: In the multiple-variable lexpit regression, the adjusted 3-year absolute risk of lung cancer in never smokers was 4.6 per 100,000 persons higher in women than men. However, the absolute increase in 3-year risk of lung cancer for every 10 additional pack-years smoked was less for women than men, 13.6 versus 52.9 per 100,000 persons. CONCLUSIONS: In a Northern Italian population, the absolute risk of lung cancer among never smokers is higher in women than men but among smokers is lower in women than men. Lexpit regression is a novel approach to additive-multiplicative risk modeling that can contribute to clearer interpretation of population-based case-control studies.
Musuraca G, De Matteis S, Napolitano R, et al., 2013, Patologic IL 17 Producing Helper T Cells In Acute Myeloid Leukemia Patients, 55th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Mensi C, Consonni D, Sieno C, et al., 2013, Sinonasal cancer and occupational exposure in a population-based registry., International Journal of Otolaryngology, Vol: 2013, ISSN: 1687-921X
We examined occupational exposures among subjects with sinonasal cancer (SNC) recorded in a population-based registry in the Lombardy Region, the most populated and industrialized Italian region. The registry collects complete clinical information and exposure to carcinogens regarding all SNC cases occurring in the population of the region. In the period 2008-2011, we recorded 210 SNC cases (137 men, 73 women). The most frequent occupational exposures were to wood (44 cases, 21.0%) and leather dust (29 cases, 13.8%), especially among men: 39 cases (28.5%) to wood and 23 cases (16.8%) to leather dust. Exposure to other agents was infrequent (<2%). Among 62 subjects with adenocarcinoma, 50% had been exposed to wood dust and 30.7% to leather dust. The proportions were around 10% in subjects with squamous cell carcinoma and about 20% for tumors with another histology. The age-standardized rates (×100,000 person-years) were 0.7 in men and 0.3 in women. Complete collection of cases and their occupational history through a specialized cancer registry is fundamental to accurately monitor SNC occurrence in a population and to uncover exposure to carcinogens in different industrial sectors, even those not considered as posing a high risk of SNC, and also in extraoccupational settings.
De Matteis S, Consonni D, Lubin J, et al., 2013, Lung cancer: Attributable to occupational exposures, Environnement, Risques et Sante, Vol: 12, Pages: 196-197, ISSN: 1635-0421
This study in Lombardy estimated the proportion of lung cancers attributable to occupational exposure to known or suspected human carcinogens. Exposure, even low, to asbestos, silica and to chromium and nickel compounds, appears to cause approximately a thousand cancer cases a year among men. Copyright © 2007 John Libbey Eurotext.
De Matteis S, Consonni D, Pesatori AC, et al., 2013, Are Women Who Smoke at Higher Risk for Lung Cancer Than Men Who Smoke?, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 177, Pages: 601-612, ISSN: 0002-9262
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- Citations: 52
De Matteis S, Consonni D, Lubin JH, et al., 2013, Authors' response to: Qualitative job-exposure matrix-a tool for the quantification of population-attributable fractions for occupational lung carcinogens?, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 42, Pages: 357-358, ISSN: 0300-5771
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- Citations: 1
Vercellini P, De Matteis S, Somigliana E, et al., 2013, Long-term adjuvant therapy for the prevention of postoperative endometrioma recurrence: a systematic review and meta-analysis, ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, Vol: 92, Pages: 8-16, ISSN: 0001-6349
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- Citations: 87
, 2013, Long-term Adjuvant Therapy for the Prevention of Postoperative Endometrioma Recurrence: A Systematic Review and Meta-analysis EDITORIAL COMMENT, OBSTETRICAL & GYNECOLOGICAL SURVEY, Vol: 68, Pages: 24-25, ISSN: 0029-7828
Cortese B, Bertoletti A, De Matteis S, et al., 2012, Drug-eluting stents perform better than bare metal stents in small coronary vessels: A meta-analysis of randomised and observational clinical studies with mid-term follow up, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 161, Pages: 73-82, ISSN: 0167-5273
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- Citations: 21
De Matteis S, Consonni D, Lubin JH, et al., 2012, Impact of occupational carcinogens on lung cancer risk in a general population, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 41, Pages: 711-721, ISSN: 0300-5771
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- Citations: 68
Consonni D, De Matteis S, Pesatori AC, et al., 2012, Increased lung cancer risk among bricklayers in an Italian population-based case-control study, AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Vol: 55, Pages: 423-428, ISSN: 0271-3586
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- Citations: 8
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