Imperial College London
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Dr Sara De Matteis

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

s.de-matteis

 
 
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Location

 

G51Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Doiron:2019:10.1183/13993003.02140-2018,
author = {Doiron, D and de, Hoogh K and Probst-Hensch, N and Fortier, I and Cai, Y and De, Matteis S and Hansell, A},
doi = {10.1183/13993003.02140-2018},
journal = {European Respiratory Journal},
title = {Air pollution, lung function and COPD: results from the population-based UK Biobank study},
url = {http://dx.doi.org/10.1183/13993003.02140-2018},
volume = {54},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ambient air pollution increases the risk of respiratory mortality but evidence for impacts on  lung  function  and chronic  obstructive  pulmonary  disease  (COPD)is  less  well established. The  aim  was  toevaluatewhether ambient air  pollution isassociated  with lung function andCOPD, and explore potential vulnerability factors. We  used  UK  Biobank  data  on 303,887 individuals  aged  40-69  years,  with complete covariate  data  and  valid  lung  function  measures.  Cross-sectional  analysesexamined associations ofLand Use Regression-based estimates ofparticulate matter (PM2.5, PM1035and PMcoarse) and nitrogen dioxide (NO2) concentrations withforced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), the FEV1/FVC ratio, and COPD (FEV1/FVC 37<  lower  limit  of  normal). Effect  modificationwas  investigated  for sex,  age,  obesity, smoking status, household income, asthma status, and occupations previously linked to COPD.40Higher exposures to each pollutant weresignificantly associated with lower lung function. A 5 μg/m3increase in PM2.5concentrationwas associated with lower FEV1(-83.13 mL [95%CI: -92.50, -73.75]) and FVC (-62.62 mL [95%CI:-73.91, -51.32]). COPD prevalence was associated with higher concentrations of PM2.5 (OR 1.52 [95%CI: 1.,1.62], per 5 μg/m3),PM10 (OR  1.08  [95%CI:  1.00,1.16],  per  5  μg/m3),  andNO2(OR  1.12  [95%CI: 1.10, 1.14], per 10 μg/m3), but not with PMcoarse.Stronger lung functionassociations were 46seenfor males, individuals from lower income households,and ‘at-risk’ occupations, and higher COPD associations for obese, lower income,and non-asthmatic participants. Ambient  air  pollution  wasassociated  with lowerlung  function  and  increased  COPD prevalencein this large study.
AU  - Doiron,D
AU  - de,Hoogh K
AU  - Probst-Hensch,N
AU  - Fortier,I
AU  - Cai,Y
AU  - De,Matteis S
AU  - Hansell,A
DO  - 10.1183/13993003.02140-2018
PY  - 2019///
SN  - 0903-1936
TI  - Air pollution, lung function and COPD: results from the population-based UK Biobank study
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.02140-2018
UR  - http://hdl.handle.net/10044/1/70272
VL  - 54
ER  -
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