Imperial College London
Portrait Picture

Dr Sara De Matteis

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
//

Contact

 

s.de-matteis

 
 
//

Location

 

G51Emmanuel Kaye BuildingRoyal Brompton Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Ratanachina:2023:10.1183/13993003.00469-2022,
author = {Ratanachina, J and Amaral, A and De, Matteis S and Lawin, H and Mortimer, K and Obaseki, D and Harrabi, I and Denguezli, M and Wouters, E and Janson, C and Nielsen, R and Gulsvik, A and Cherkaski, H and Mejza, F and Anand, M and Elsony, A and Ahmed, R and Tan, W and Loh, LC and Rashid, A and Studnicka, M and Nafees, A and Seemungal, T and Aquart-Stewart, A and Al, Ghobain M and Zheng, J and Juvekar, S and Salvi, S and Jogi, R and Mannino, D and Gislason, T and Buist, AS and Cullinan, P and Burney, P},
doi = {10.1183/13993003.00469-2022},
journal = {European Respiratory Journal},
pages = {1--16},
title = {Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study},
url = {http://dx.doi.org/10.1183/13993003.00469-2022},
volume = {60},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study.We analysed cross-sectional data from 28,823 adults (≥40years) in 34 countries. Eleven occupations were considered and grouped by likelihood of exposure to organic dusts, inorganic dusts and fumes. The association of chronic cough, chronic phlegm, wheeze, dyspnoea, FEV1/FVC and FVC with occupation was assessed, per study site, using multivariable regression. These estimates were then meta-analysed. Sensitivity analyses explored differences between sexes and gross national income (GNI).Overall, working in settings with potentially high exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. The most common occupation was farming. Compared to people not working in any of the 11 considered occupations, those who were farmers for ≥20years were more likely to have chronic cough (OR=1.52, 95%CI 1.19-1.94), wheeze (OR=1.37, 95%CI 1.16-1.63), and dyspnoea (OR=1.83, 95%CI 1.53-2.20), but not lower FVC (β=0.02L, 95%CI -0.02L to 0.06L) or lower FEV1/FVC (β=0.04%, 95%CI -0.49% to 0.58%). Some findings differed by sex and GNI. In summary, at a population level, the occupational exposures considered in this study do not appear to be major determinants of differences in lung function, although they associate with more respiratory symptoms. As not all work settings were included in this study, respiratory surveillance should still be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.
AU  - Ratanachina,J
AU  - Amaral,A
AU  - De,Matteis S
AU  - Lawin,H
AU  - Mortimer,K
AU  - Obaseki,D
AU  - Harrabi,I
AU  - Denguezli,M
AU  - Wouters,E
AU  - Janson,C
AU  - Nielsen,R
AU  - Gulsvik,A
AU  - Cherkaski,H
AU  - Mejza,F
AU  - Anand,M
AU  - Elsony,A
AU  - Ahmed,R
AU  - Tan,W
AU  - Loh,LC
AU  - Rashid,A
AU  - Studnicka,M
AU  - Nafees,A
AU  - Seemungal,T
AU  - Aquart-Stewart,A
AU  - Al,Ghobain M
AU  - Zheng,J
AU  - Juvekar,S
AU  - Salvi,S
AU  - Jogi,R
AU  - Mannino,D
AU  - Gislason,T
AU  - Buist,AS
AU  - Cullinan,P
AU  - Burney,P
DO  - 10.1183/13993003.00469-2022
EP  - 16
PY  - 2023///
SN  - 0903-1936
SP  - 1
TI  - Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.00469-2022
UR  - https://erj.ersjournals.com/content/61/1/2200469
UR  - http://hdl.handle.net/10044/1/98639
VL  - 60
ER  -
Download