Imperial College London
Alternate

DrSaraDe Simoni

Faculty of Medicine, Department of Brain Sciences

Honorary Research Associate
 
 
 
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Contact

 

s.de-simoni

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mallas:2021:brain/awaa380,
author = {Mallas, E-J and De, Simoni S and Scott, G and Jolly, A and Hampshire, A and Li, L and Bourke, N and Roberts, S and Gorgoraptis, N and Sharp, D},
doi = {brain/awaa380},
journal = {Brain: a journal of neurology},
pages = {114--127},
title = {Abnormal dorsal attention network activation in memory impairment after traumatic brain injury},
url = {http://dx.doi.org/10.1093/brain/awaa380},
volume = {144},
year = {2021}
}
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TY  - JOUR
AB  - Memory impairment is a common, disabling effect of traumatic brain injury. In healthy individuals,  successful memory encoding is associated  with activation of  the dorsal attention  network  as  well  as  suppression  of  the  default  mode  network.  Here,  in traumatic  brain  injurypatients  we  examined  whether:  i)  impairments  in  memory encoding are associated with abnormal brain activation in these networks; ii) whether changes  in  this  brain  activity  predict  subsequent  memory  retrieval;  and  iii)  whether abnormal  white  matter  integrity  underpinningfunctional  networks  is  associated  with impaired subsequent memory. 35 patients with moderate-severetraumatic brain injury aged  23-65  years  (74%  males)  in  the  post-acute/chronic  phase  after  injury and  16 healthy  controls  underwent  functional  MRI  during  performance  of  an  abstract  image memory  encoding task. Diffusion tensor  imaging was  used  to  assess  structural abnormalities  across  patient  groups  compared  to 28  age-matched healthy  controls. Successful memory encoding across all participants was associated with activation of the  dorsal attention  network,  the  ventral  visual  stream  and  medial  temporal lobes. Decreased  activation  was  seen  in  the  default  mode  network. Patients with preserved episodic  memory  demonstrated  increased activation  in  areas  of  the  dorsal  attention network.Patients with  impaired  memory  showed  increased  left  anterior  prefrontal activity. White matter microstructure underpinning connectivity between core nodes of the encoding networks was significantly reduced in patients with memory impairment. Our results show for the first time that patients with impaired episodic memory show abnormal  activation  of  key  nodes  within  the  dorsal  attention  network  and  regions regulating  default  mode  network  activity  during  encoding. Successful  encoding  was associated  with  an  opposite  direction  of  signal
AU  - Mallas,E-J
AU  - De,Simoni S
AU  - Scott,G
AU  - Jolly,A
AU  - Hampshire,A
AU  - Li,L
AU  - Bourke,N
AU  - Roberts,S
AU  - Gorgoraptis,N
AU  - Sharp,D
DO  - brain/awaa380
EP  - 127
PY  - 2021///
SN  - 0006-8950
SP  - 114
TI  - Abnormal dorsal attention network activation in memory impairment after traumatic brain injury
T2  - Brain: a journal of neurology
UR  - http://dx.doi.org/10.1093/brain/awaa380
UR  - https://academic.oup.com/brain/article/144/1/114/6050087
UR  - http://hdl.handle.net/10044/1/83390
VL  - 144
ER  -
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