Publications
333 results found
Deb S, 2015, Ratti V., Hassiotis A., Deb S. and Unwin G. (2015) The effectiveness of person-centred planning for people with intellectual disabilities: a systematic search and literature review. European Association of Mental Health in Intellectual Disability Conference, Florence., European Association of Mental Health in Intellectual Disability Conference, Florence.
Deb S, 2015, Ratti V., Hassiotis A., Deb S. and Unwin G. (2015) The effectiveness of person-centred planning for people with intellectual disabilities: a search and literature review. Journal of Intellectual Disability Research, 59 (1), 90., Journal of Intellectual Disability Research.
Roy A, Roy M, Deb S, et al., 2015, Are opioid antagonists effective in attenuating the core symptoms of autism spectrum conditions in children: a systematic review, JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Vol: 59, Pages: 293-306, ISSN: 0964-2633
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- Citations: 42
Li RSY, Kwok HWM, Deb S, et al., 2015, Validation of the Chinese Version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID-CV), JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Vol: 59, Pages: 385-395, ISSN: 0964-2633
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- Citations: 7
Deb S, Matthews T, Holt G, et al., 2015, Practice Guidelines for the Assessment and Diagnosis of Mental Health Problems in Adults with Intellectual Disability: Croatian translation, Publisher: Hrvatsko društvo za mentalno zdravlje osoba s intelektualnim teškoćama i razvojnim poremećajima, HDMZITRP, ISBN: 978-953-176-697-5
Deb S, 2015, Deb S. (2015) Guide to using psychotropic medications to manage problem behaviours among adults with intellectual developmental disorders. In ‘Clinical Topics in the Psychiatry of Disorders of Intellectual Development’ (Ed. M. Woodbury-Smith). Royal College of Psychiatrists Publications, London, UK. Pp. 130-144., Clinical Topics in the Psychiatry of Disorders of Intellectual Development.
Deb S, Unwin G, Deb T, 2015, Characteristics and the trajectory of psychotropic medication use in general and antipsychotics in particular among adults with an intellectual disability who exhibit aggressive behaviour, JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Vol: 59, Pages: 11-25, ISSN: 0964-2633
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- Citations: 55
Roy A, Roy M, Deb S, et al., 2014, Are opioid antagonists effective in reducing self-injury in adults with intellectual disability? A systematic review, Journal of Intellectual Disability Research, Vol: 59, Pages: 55-67, ISSN: 1365-2788
BackgroundSelf-injury in people with intellectual disability (ID) may be due to variety of factors both environmental and biological. As the drive in UK is to manage people with ID and problem behaviours in the community, it is important to critically examine all treatment options available. As abnormalities in the endogenous opioid system may be a factor in some people with ID, we undertook a systematic review to evaluate the evidence for the effectiveness of opioid antagonists.MethodsFour electronic databases were searched for relevant journal articles. In addition, cross-referencing of pertinent reviews and a hand search for articles in major international ID journals between the years 2010 and 2012 was carried out to ensure that all relevant articles were identified. We also searched databases for unpublished clinical trials to overcome publication bias. Each database was searched up to present (February 2013) with no restrictions on the date of publication. The search terms consisted of broad expressions used to describe ID and autistic spectrum disorder as well as terms relating to opioid antagonists and specific drugs. All studies identified by the electronic database search and hand search were examined on the basis of title alone for relevance and duplication. The abstracts of the remaining papers were then scrutinised against the inclusion criteria. Where abstracts failed to provide adequate information, the full texts for these papers were obtained. All the full texts were then evaluated against the inclusion proforma. Two reviewers carried out all the stages of the process independently. The reviewers met to discuss their selections and where disagreements arose, these were settled by discussion with a member of the study group. Data from each study meeting the inclusion criteria was extracted on a pre-piloted data extraction form. The quality of each study was further assessed using the Jadad scale, a tool developed to assess the quality of randomised c
Unwin G, Deb S, 2014, Caregiver's concerns-quality of life scale (CC-QoLS): development and evaluation of psychometric properties., Res Dev Disabil, Vol: 35, Pages: 2329-2340
We have developed a Caregiver's Concerns-Quality of Life Scale (CC-QoLS) for adults with intellectual disabilities (ID) who exhibit aggressive behaviour. The CC-QoLS is a brief (8 items in each subscale, CC and QoL respectively) proxy measure completed by caregivers. This is a specific health related quality of life instrument (HRQoL) combined with measures of caregiver's concerns for use as an outcome measure to assess clinical and cost effectiveness of interventions for aggression in adults with ID. The CC-QoLS was found to have good face validity and very good test-retest reliability with an ICC of 0.81 for CC (range 0.46-0.83 across items) and 0.80 for QoL (range 0.65-0.81 across items). Similarly, the scale had good inter-rater reliability with an ICC of 0.67 for CC (range 0.31-0.63 across items) and 0.63 for QoL (range 0.31-0.65 across items). Internal consistency for each subscale was also good (Cronbach's alpha was 0.85 for CC and 0.80 for QoL; Split-half Spearman-Brown was 0.81 for CC and 0.70 for QoL). Furthermore, the scale showed good concurrent validity with measures of severity of aggressive behaviour, namely Modified Overt Aggression Scale (MOAS) (CC: r=0.4; p≤0.01 and QoL: r=-0.2; p≤0.05) and Aberrant Behavior Checklist-Irritability subscale (ABC-I) (CC: r=0.5; p≤0.01 and QoL: r=-0.02; p≤0.05) as well as Caregiver's Uplift and Burden Scale score (<0.05). We believe that the CC-QoLS is a user friendly, easy to complete, first-ever HRQoL measure for adults with ID and aggressive behaviour with very good psychometric properties.
Deb S, 2014, Deb S. (2014) Highlights in psychopharmacology of intellectual developmental disorders. XVI World Congress in Psychiatry, Madrid, World Psychiatric Association. Abstract Section Symposia, SSY 583, vol. 1, page 175-176. www.wpamadrid2014.com, XVI World Congress in Psychiatry, Madrid, World Psychiatric Association.
Deb S, 2014, Unwin G., Deb S. & Rose J. (2014) Topography and trajectory of aggressive behaviour among a clinical sample of adults with Intellectual Disabilities. Intellectual Disability Faculty, Royal College of Psychiatrists, Annual Residential Conference, Birmingham., Royal College of Psychiatrists, Annual Residential Conference, Birmingham.
Deb S, 2014, Deb S., Farmah B. K., Arshad E., Deb T., Roy M., Unwin G. (2014) The effectiveness of aripiprazole in the management of problem behaviour in people with intellectual disabilities, developmental disabilities and/or autism spectrum disorder-a systematic review. Intellectual Disability Faculty, Royal College of Psychiatrists, Annual Residential Conference, Birmingham.
Deb S, 2014, Unwin G., Deb S. & Rose J. (2014) Factors associated with severity and types of aggressive behaviour: a longitudinal study. Intellectual Disability Faculty, Royal College of Psychiatrists, Annual Residential Conference, Birmingham.
Njomboro P, Deb S, 2014, Distinct neuropsychological correlates of cognitive, behavioral, and affective apathy sub-domains in acquired brain injury, Frontiers in Neurology, Vol: 5, Pages: 73-73, ISSN: 1664-2295
Apathy has a high prevalence and a significant contribution to treatment and rehabilitation outcomes in acquired brain damage. Research on the disorder's neuropsychological correlates has produced mixed results. While the mixed picture may be due to the use of varied assessment tools on different patient populations, it is also the case that most studies treat apathy as a unitary syndrome. This is despite the evidence that apathy is a multifaceted and multidimensional syndrome. This study investigates the neuropsychological correlates of apathy in 49 patients with acquired brain damage. It further fractionates apathy symptoms into affective, cognitive, and behavioral sub-domains and investigates their individual relations with standard measures of affective, cognitive, and behavioral functioning. Global apathy scores were not related to any of these measures. Affective apathy was associated with emotion perception deficits, and cognitive apathy was associated with executive deficits on the Brixton test. These results demonstrate that treating apathy as a single entity may hide important correlates to apathy symptoms that become visible when the disorder is fractionated into its sub-domains. The study highlights the research and clinical importance of treating apathy as a multidimensional syndrome.
Deb S, Farmah BK, Arshad E, et al., 2014, The effectiveness of aripiprazole in the management of problem behaviour in people with intellectual disabilities, developmental disabilities and/or autistic spectrum disorder - A systematic review, RESEARCH IN DEVELOPMENTAL DISABILITIES, Vol: 35, Pages: 711-725, ISSN: 0891-4222
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- Citations: 44
Bertelli MO, Salvador-Carulla L, Scuticchio D, et al., 2014, Moving beyond intelligence in the revision of ICD-10: specific cognitive functions in intellectual developmental disorders, WORLD PSYCHIATRY, Vol: 13, Pages: 93-94, ISSN: 1723-8617
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- Citations: 19
Njomboro P, Humphreys GW, Deb S, 2014, Exploring social cognition in patients with apathy following acquired brain damage, BMC Neurology, Vol: 14, ISSN: 1471-2377
BACKGROUND: Research on cognition in apathy has largely focused on executive functions. To the best of our knowledge, no studies have investigated the relationship between apathy symptoms and processes involved in social cognition. Apathy symptoms include attenuated emotional behaviour, low social engagement and social withdrawal, all of which may be linked to underlying socio-cognitive deficits. METHODS: We compared patients with brain damage who also had apathy symptoms against similar patients with brain damage but without apathy symptoms. Both patient groups were also compared against normal controls on key socio-cognitive measures involving moral reasoning, social awareness related to making judgements between normative and non-normative behaviour, Theory of Mind processing, and the perception of facial expressions of emotion. We also controlled for the likely effects of executive deficits and depressive symptoms on these comparisons. RESULTS: Our results indicated that patients with apathy were distinctively impaired in making moral reasoning decisions and in judging the social appropriateness of behaviour. Deficits in Theory of Mind and perception of facial expressions of emotion did not distinguish patients with apathy from those without apathy. CONCLUSION: Our findings point to a possible socio-cognitive profile for apathy symptoms and provide initial insights into how socio-cognitive deficits in patients with apathy may affect social functioning.
Ward F, Tharian P, Roy M, et al., 2013, Efficacy of beta blockers in the management of problem behaviours in people with intellectual disabilities: A systematic review, RESEARCH IN DEVELOPMENTAL DISABILITIES, Vol: 34, Pages: 4293-4303, ISSN: 0891-4222
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- Citations: 16
Deb S, 2013, Okafor G. E., Deb S., Cavanna A. E., Unwin G. (2013) Psychopathology in adults with intellectual disabilities with or without epilepsy: A case control study. Epilepsia, 54, 110., Epilepsia., ISSN: 0013-9580
Deb S, 2013, Okafor G. E., Deb S., Cavanna A. E., Unwin G. (2013) Psychopathology in adults with intellectual disabilities with or without epilepsy: A case control study. Journal of Neurology, Neurosurgery and Psychiatry, 84, e1. doi: 10.1136/jnnp-2013-306103.23, Journal of Neurology, Neurosurgery and Psychiatry., ISSN: 0022-3050
Deb S, 2013, Okafor G., Deb S. & Unwin G. (2013) Psychopathology in adults with intellectual disabilities with or without epilepsy: A case control study. Presented at the 30th International Epilepsy Congress, Montreal, Canada.
Deb S, 2013, Unwin G., Mistry H. & Deb S. (2012) Specialist Health Service Utilisation for the Management of Aggression in Adults with Intellectual Disabilities. Mental Health Research Network National Conference, Birmingham, UK.
Deb S, 2013, Okafor G. E., Deb S., Cavanna A. E., Unwin G. (2013) Psychopathology in adults with intellectual disabilities with or without epilepsy: A case control study. Journal of Neurology, Neurosurgery and Psychiatry, 84, e1. doi: 10.1136/jnnp-2013-306103.23, Journal of Neurology, Neurosurgery and Psychiatry., ISSN: 0022-3050
Chechlacz M, Rotshtein P, Hansen PC, et al., 2013, The central role of the temporo-parietal junction and the superior longitudinal fasciculus in supporting multi-item competition: Evidence from lesion-symptom mapping of extinction, CORTEX, Vol: 49, Pages: 487-506, ISSN: 0010-9452
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- Citations: 52
Deb S, 2013, Deb S. & Srikanth R. (2013) Epilepsy and Intellectual Disability. The Royal College of Psychiatrists, UK, Online CPD Module (updated version). www.psychiatrycpd.org, www.psychiatrycpd.org
Deb S, 2013, Deb S. (2013) Psychopharmacology. In ‘Handbook of Psychopathology in Intellectual Disability: Research, Practice, and Policy, Autism and Child Psychopathology Series’ (Eds. E. Tsakanikos & J. McCarthy) Springer Science + Business Media, New York, USA (book chapter, 19). (Series Editor: Johnny L. Matson). Pp. 307-324., Handbook of Psychopathology in Intellectual Disability: Research, Practice, and Policy, Autism and Child Psychopathology Series.
Hemmings C, Deb S, Chaplin E, et al., 2013, Review of Research for People With ID and Mental Health Problems: A View From the United Kingdom, JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES, Vol: 6, Pages: 127-158, ISSN: 1931-5864
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- Citations: 27
Njomboro P, Deb S, Humphreys GW, 2012, Apathy symptoms modulate motivational decision making on the Iowa gambling task, Behavioral and Brain Functions, Vol: 8, Pages: 1-8, ISSN: 1744-9081
BackgroundThe present study represents an initial attempt to assess the role of apathy in motivated decision making on the Iowa Gambling Task. Clinical descriptions of patients with apathy highlight deficits in the cognitive, emotional and behavioural aspects of goal directed activity, yet standard neurocognitive tests of these measures fail to demonstrate reliable sensitivity to the disorder. Available research suggests the Iowa Gambling Task is a robust test of complex emotional socio-executive processes involved in motivational decision making, which can analogue real-world goal-directed behaviour.MethodsWe ask whether performance on the Iowa Gambling Task can distinguish brain damaged patients with apathy symptoms from 1) brain damaged patients without apathy and 2) neurologically intact controls. Overall, 22 healthy adults and 29 brain damaged patients took part in this study.ResultsBrain damaged patients with apathy were distinctively impaired on the Iowa Gambling Task compared to both non-apathetic brain damaged patients and neurologically intact healthy controls. On the other hand, standard measures for the cognitive control of behaviour failed to show this sensitivity.ConclusionsOur results demonstrated that the Iowa Gambling Task is sensitive to the presence of apathy symptoms. We discuss these findings in terms of neurocognition deficits in apathy and the related implications for rehabilitation and clinical intervention.
Deb S, 2012, Singh S. P., Burns T., Crawford M., Tyrer P., Paul M., Deb S., Islam Z., Rugkasa J., Champaneri N., Griffiths F., Thorpe S. & Parsons H. (2012) Assessing the impact of the Mental Health Act 2007 (AMEND) (March 2009-June 2012). Department of Health, UK report, DH.
Njomboro P, Deb S, Humphreys GW, 2012, Apathy and executive functions: insights from brain damage involving the anterior cingulate cortex., BMJ Case Rep, Vol: 2012
Patients with anterior cingulate cortex (ACC) lesions present an opportunity for understanding apathy's disputed neuropsychiatric features, as well as its associated neurocognitive phenotype. In this case report, two male patients (patient A and patient B) with lesions involving the ACC bilaterally were assessed for apathy, depressive symptoms, executive functioning, and also tested on the Iowa Gambling Task (IGT). Twenty neurologically intact controls also provided normative scores on the IGT. Patient A and patient B had high scores for apathy and low depressive symptoms scores. Patient A had relatively intact performance on standard executive function tests, but patient B had significant impairments. Both patients were significantly impaired on the IGT. Our findings suggest that executive function deficits are not crucial for the presence of apathy symptoms. These findings not only shed light on the relationship between apathy and executive function deficits, but also have important implications for patient care and rehabilitation.
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