Imperial College London
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Professor Shoumitro (Shoumi) Deb

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 4161s.deb CV

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Deb:2022:10.1007/978-3-319-95720-3,
author = {Deb, S and Strydom, A and Hithersay, R and Gomiero, T and De, Vreese LP and Janicki, MP and Jokinen, NS and Service, KP},
booktitle = {Textbook of Psychiatry for Intellectual Disability and Autism Spectrum Disorder.},
doi = {10.1007/978-3-319-95720-3},
editor = {Bertelli and Deb and Munir and Hassiotis and Salvador-Carulla},
pages = {719--756},
publisher = {Springer Nature Switzerland AG 2022},
title = {Dementia in People  with Intellectual  Disabilities},
url = {http://dx.doi.org/10.1007/978-3-319-95720-3},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - With the increasing life expectancy in the last five decades, people with intellectual disabilities (ID) are exposed to the risk of age-related neurodegenerative disorders including dementia. The prevalence of dementia is increased in people with ID compared with that in the general population. People with Down syndrome (DS) are even at a higher risk of developing Alzheimer’s dementia (AD) compared with non-DS people with ID. However, there are difficulties in making an early and accurate diagnosis of dementia in individuals with ID and the screening instruments such as the Mini Mental Status Examination that are used in the general population often show floor effects when used for individuals with ID because of their pre-existing cognitive impairment, the level of which varies depending on the severity of ID. Both informant-rated and direct neuropsychological tests have been used for the case detection of dementia for individuals with ID. However, direct neuropsychological tests cannot be used for those who have severe ID and their validity could still be questionable in a number of cases of mild to moderate ID. There are many similarities and some differences in the clinical manifestation of dementia in individuals with ID and the non-ID general population. Impaired recent memory and confusion in the context of relatively intact distant memory is likely to be an early symptom in individuals with ID who have a mild ID, whereas loss of skills and behaviour changes are likely to be an early feature for those with more severe ID. Many symptoms, including features of ‘frontal lobe dysfunction’ that tend to appear late in the dementing process in the general population, may appear early in individuals with ID and DS.Ideally, individuals with ID should be screened for signs of dementia from before the age of 30/35. A multi-disciplinary approach should be taken for diagnosis of dementia in individuals with ID using a combination of informant-rated scal
AU  - Deb,S
AU  - Strydom,A
AU  - Hithersay,R
AU  - Gomiero,T
AU  - De,Vreese LP
AU  - Janicki,MP
AU  - Jokinen,NS
AU  - Service,KP
DO  - 10.1007/978-3-319-95720-3
EP  - 756
PB  - Springer Nature Switzerland AG 2022
PY  - 2022///
SN  - 978-3-319-95719-7
SP  - 719
TI  - Dementia in People  with Intellectual  Disabilities
T1  - Textbook of Psychiatry for Intellectual Disability and Autism Spectrum Disorder.
UR  - http://dx.doi.org/10.1007/978-3-319-95720-3
ER  -
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