Imperial College London
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Professor Shoumitro (Shoumi) Deb

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 4161s.deb CV

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Deb:2015:10.2174/97816810813801150101,
author = {Deb, S},
booktitle = {Recent Advances in Alzheimer Research},
doi = {10.2174/97816810813801150101},
pages = {69--89},
publisher = {Bentham Books},
title = {Managing Problem Behaviors in People with Down Syndrome and Alzheimer’s Disease},
url = {http://dx.doi.org/10.2174/97816810813801150101},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Behavioral and psychological symptoms of Alzheimer’s disease and otherdementias may create a considerable burden of care in the general population, yetrelatively little research has been carried out in this area. Although problem behaviorsmay be relatively less frequent in people with Down syndrome who developAlzheimer’s dementia, nevertheless they cause additional caregiver burden. Bothpharmacological and non-pharmacological interventions are used for the managementof problem behaviors in people with intellectual disability in general. Similarly, bothpharmacological and non-pharmacological interventions are used to manage symptomsof dementia including behavioral symptoms in the general population. Treatmentapproaches used in both these groups could equally be used to manage problembehaviors in people with Down syndrome who develop dementia. Extrapolatedevidence from studies on children with autism spectrum disorder and intellectualdisability possibly supports use of risperidone for management of problem behavior inadults with Down syndrome and dementia. RCT-based evidence exists to support use ofantipsychotics, mood stabilizers, and cholinesterase inhibitors for the management ofbehavioral and psychological symptoms of dementia in the general population but nospecific evidence for Down syndrome exists. Clinicians have to be mindful of potentialserious central nervous system adverse effects of antipsychotics in people withdementia. Similarly, evidence for efficacy of non-pharmacological interventions forproblem behaviors both in the general population with dementia and people withintellectual disability in general is too equivocal to make any definitiverecommendation at this stage for people with Down syndrome and dementia. Recentlythere has been an emphasis on providing person-centered service specifically designedfor people with dementia. Another important aspect of management is training andsupport for caregivers and care staff to help people with dem
AU  - Deb,S
DO  - 10.2174/97816810813801150101
EP  - 89
PB  - Bentham Books
PY  - 2015///
SN  - 978-1-68108-139-7
SP  - 69
TI  - Managing Problem Behaviors in People with Down Syndrome and Alzheimer’s Disease
T1  - Recent Advances in Alzheimer Research
UR  - http://dx.doi.org/10.2174/97816810813801150101
ER  -
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