Imperial College London
Portrait Picture

Professor Shoumitro (Shoumi) Deb

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 4161s.deb CV

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Deb:2015:10.2174/97816810813801150101,
author = {Deb, S},
booktitle = {Recent Advances in Alzheimer Research},
doi = {10.2174/97816810813801150101},
pages = {42--68},
publisher = {Bentham Books},
title = {Diagnosing Alzheimer’s Dementia in People with Down Syndrome},
url = {http://dx.doi.org/10.2174/97816810813801150101},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - There are difficulties in making an early and accurate diagnosis of dementiain individuals with DS; in screening instruments such as the Mini Mental StatusExamination that are used in the general population often show floor effects when usedfor individuals with Down syndrome (DS) because of their pre-existing cognitiveimpairment, the level of which varies depending on the severity of intellectual disability(ID). Both informant-rated scales and direct neuropsychological tests have been usedfor the case detection of dementia for individuals with DS. However, directneuropsychological tests cannot be used for those who have severe ID and their validitycould still be questionable in a number of cases of mild to moderate ID. Therefore, useof informant-rated scales is desirable for screening purposes.There are many similarities and some differences in the clinical expression of dementiain individuals with DS and the general population who do not have ID. Impaired recentmemory and confusion in the context of relatively intact distant memory is likely to bean early symptom in individuals with DS who have mild ID, whereas loss of skills andbehavior changes are likely to be an early feature for those with more severe ID. Manysymptoms, including features of ‘frontal lobe dysfunction’ that tend to appear late in thedementing process in the general population, may appear early in individuals with DS.An important early sign is any change in behavior or functioning, and dementia mustalways be considered as a possible cause for the change.Ideally, individuals with DS should be screened for signs of dementia from before theage of 30-35. A multi-disciplinary approach should be taken for diagnosis of dementiain individuals with DS using a combination of informant-rated scales andneuropsychological tests in a longitudinal fashion over time. Important differentialdiagnoses include hypothyroidism, depression, and sensory impairment. Assessmentshould include physical, psycholog
AU  - Deb,S
DO  - 10.2174/97816810813801150101
EP  - 68
PB  - Bentham Books
PY  - 2015///
SN  - 978-1-68108-139-7
SP  - 42
TI  - Diagnosing Alzheimer’s Dementia in People with Down Syndrome
T1  - Recent Advances in Alzheimer Research
UR  - http://dx.doi.org/10.2174/97816810813801150101
ER  -
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