Imperial College London
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ProfessorSimoneDi Giovanni

Faculty of Medicine, Department of Brain Sciences

James W Harnett Chair in Restorative Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 3178s.di-giovanni

 
 
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Location

 

E505Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nagy:2022:10.3390/ijms23020752,
author = {Nagy, I and Irfan, J and Febrianto, M and Sharma, A and Rose, T and Mahmudzade, Y and Di, Giovanni S and Torres-Perez, J},
doi = {10.3390/ijms23020752},
journal = {International Journal of Molecular Sciences},
pages = {1--29},
title = {DNA methylation and non-coding RNAs during tissue-injury associated pain},
url = {http://dx.doi.org/10.3390/ijms23020752},
volume = {23},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - While about half of the population experience persistent pain associated with tissue damages during their lifetime, current symptom-based approaches often fail to reduce such pain to a satisfactory level. To provide better patient care, mechanism-based analgesic approaches must be developed, which necessitates a comprehensive understanding of the nociceptive mechanism leading to tissue injury-associated persistent pain. Epigenetic events leading the altered transcription in the nervous system are pivotal in the maintenance of pain in tissue injury. However, the mechanisms through which those events contribute to the persistence of pain are not fully understood. This review provides a summary and critical evaluation of two epigenetic mechanisms, DNA methylation and non-coding RNA expression, on transcriptional modulation in nociceptive pathways during the development of tissue injury-associated pain. We assess the pre-clinical data and their translational implication and evaluate the potential of controlling DNA methylation and non-coding RNA expression as novel analgesic approaches and/or biomarkers of persistent pain.
AU  - Nagy,I
AU  - Irfan,J
AU  - Febrianto,M
AU  - Sharma,A
AU  - Rose,T
AU  - Mahmudzade,Y
AU  - Di,Giovanni S
AU  - Torres-Perez,J
DO  - 10.3390/ijms23020752
EP  - 29
PY  - 2022///
SN  - 1422-0067
SP  - 1
TI  - DNA methylation and non-coding RNAs during tissue-injury associated pain
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms23020752
UR  - https://www.mdpi.com/1422-0067/23/2/752
UR  - http://hdl.handle.net/10044/1/94271
VL  - 23
ER  -
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