Imperial College London
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ProfessorSimoneDi Giovanni

Faculty of Medicine, Department of Brain Sciences

James W Harnett Chair in Restorative Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 3178s.di-giovanni

 
 
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Location

 

E505Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Quadrato:2012:10.1073/pnas.1202068109,
author = {Quadrato, G and Benevento, M and Alber, S and Jacob, C and Floriddia, EM and Nguyen, T and Elnaggar, MY and Pedroarena, CM and Molkentin, JD and Di, Giovanni S},
doi = {10.1073/pnas.1202068109},
journal = {Proceedings of the National Academy of Sciences},
title = {Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus},
url = {http://dx.doi.org/10.1073/pnas.1202068109},
volume = {109},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:p>            New neurons generated in the adult dentate gyrus are constantly integrated into the hippocampal circuitry and activated during encoding and recall of new memories. Despite identification of extracellular signals that regulate survival and integration of adult-born neurons such as neurotrophins and neurotransmitters, the nature of the intracellular modulators required to transduce those signals remains elusive. Here, we provide evidence of the expression and transcriptional activity of nuclear factor of activated T cell c4 (NFATc4) in hippocampal progenitor cells. We show that NFATc4 calcineurin-dependent activity is required selectively for survival of adult-born neurons in response to BDNF signaling. Indeed, cyclosporin A injection and stereotaxic delivery of the BDNF scavenger TrkB-Fc in the mouse dentate gyrus reduce the survival of hippocampal adult-born neurons in wild-type but not in NFATc4            <jats:sup>−/−</jats:sup>            mice and do not affect the net rate of neural precursor proliferation and their fate commitment. Furthermore, associated with the reduced survival of adult-born neurons, the absence of NFATc4 leads to selective defects in LTP and in the encoding of hippocampal-dependent spatial memories. Thus, our data demonstrate that NFATc4 is essential in the regulation of adult hippocampal neurogenesis and identify NFATc4 as a central player of BDNF–driven prosurvival signaling in hippocampal adult-born neurons.          </jats:p>
AU  - Quadrato,G
AU  - Benevento,M
AU  - Alber,S
AU  - Jacob,C
AU  - Floriddia,EM
AU  - Nguyen,T
AU  - Elnaggar,MY
AU  - Pedroarena,CM
AU  - Molkentin,JD
AU  - Di,Giovanni S
DO  - 10.1073/pnas.1202068109
PY  - 2012///
SN  - 0027-8424
TI  - Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus
T2  - Proceedings of the National Academy of Sciences
UR  - http://dx.doi.org/10.1073/pnas.1202068109
VL  - 109
ER  -
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