Imperial College London
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ProfessorSimoneDi Giovanni

Faculty of Medicine, Department of Brain Sciences

James W Harnett Chair in Restorative Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 3178s.di-giovanni

 
 
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Location

 

E505Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Puttagunta:2014:10.1038/ncomms4527,
author = {Puttagunta, R and Tedeschi, A and Soria, MG and Hervera, A and Lindner, R and Rathore, KI and Gaub, P and Joshi, Y and Tuan, N and Schmandke, A and Laskowski, CJ and Boutillier, A-L and Bradke, F and Di, Giovanni S},
doi = {10.1038/ncomms4527},
journal = {Nature Communications},
title = {PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system},
url = {http://dx.doi.org/10.1038/ncomms4527},
volume = {5},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Axonal regenerative failure is a major cause of neurological impairment following central nervous system (CNS) but not peripheral nervous system (PNS) injury. Notably, PNS injury triggers a coordinated regenerative gene expression programme. However, the molecular link between retrograde signalling and the regulation of this gene expression programme that leads to the differential regenerative capacity remains elusive. Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. Furthermore, we find that extracellular signal-regulated kinase (ERK)-mediated retrograde signalling is required for PCAF-dependent regenerative gene reprogramming. Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury. Thus, we find a specific epigenetic mechanism that regulates axonal regeneration of CNS axons, suggesting novel targets for clinical application.
AU  - Puttagunta,R
AU  - Tedeschi,A
AU  - Soria,MG
AU  - Hervera,A
AU  - Lindner,R
AU  - Rathore,KI
AU  - Gaub,P
AU  - Joshi,Y
AU  - Tuan,N
AU  - Schmandke,A
AU  - Laskowski,CJ
AU  - Boutillier,A-L
AU  - Bradke,F
AU  - Di,Giovanni S
DO  - 10.1038/ncomms4527
PY  - 2014///
SN  - 2041-1723
TI  - PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms4527
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209867600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 5
ER  -
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