Publications
803 results found
Zadoyan G, Shah-Hosseini K, Astvatsatourov A, et al., 2015, A prospective, randomized, double-blind placebo-controlled multi-centre dose-finding study of 3 different regimens of gpASIT plus ™ administered subcutaneously to adult patients with grass pollen-induced allergic rhinoconjunctivitis, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 41-42, ISSN: 0105-4538
Shamji MH, Kasche EM, Zadoyan G, et al., 2015, Hydrolyzed Lolium perenne peptide fragments administered subcutaneously to hay fever patients induce allergen-specific IgG<sub>4</sub> and blocking antibodies after two or more weeks of treatment, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 631-632, ISSN: 0105-4538
Lam EPS, Kariyawasam HH, Rana BMJ, et al., 2015, IL-25 and IL-33-responsive oligoclonal Th2 cells characterize nasal polyps with Th17 as the default signature in healthy nasal mucosa, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 105-105, ISSN: 0105-4538
Kleine-Tebbe J, de Blay F, Fernandez FR, et al., 2015, Quantitative benefit and risk assessment of SQ HDM SLIT-tablet; results from a DBPC phase III trial in allergic asthma, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 261-262, ISSN: 0105-4538
Chaker AM, Shamji MH, Dumitru FA, et al., 2015, Pre-seasonal combined grass pollen immunotherapy and anti-IL-4: a randomised controlled trial, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 41-41, ISSN: 0105-4538
Makatsori M, Skypala I, Mc Kenzie R, et al., 2015, Outcomes of open food challenges in adults, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 46-46, ISSN: 0105-4538
Ruiz Garcia M, Hayward C, Sim M, et al., 2015, Electrocardiographic changes during acute peanut allergic reactions in adults, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 492-492, ISSN: 0105-4538
Garcia RM, Wilson E, Clark A, et al., 2015, Cardiovascular haemodynamic changes during acute peanut allergic reactions in adults, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 32-33, ISSN: 0105-4538
Dua S, Ruiz-Garcia M, Bond S, et al., 2015, Thresholds reactivity and clinical evaluation (TRACE) study: investigation of the effect of extrinsic factors on peanut allergic reactions, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 183-184, ISSN: 0105-4538
Turner PJ, Ruiz-Garcia M, Parkin R, et al., 2015, Basophil activation during - but not prior to - IgE-mediated allergic reactions to peanut correlates with symptom severity, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 48-48, ISSN: 0105-4538
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- Citations: 1
Scadding GW, Eifan AO, Lao-Araya M, et al., 2015, Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge (vol 70, pg 689, 2015), ALLERGY, Vol: 70, Pages: 1033-1033, ISSN: 0105-4538
Scadding GW, Eifan AO, Lao-Araya M, et al., 2015, Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge, Allergy, Vol: 70, Pages: 689-696, ISSN: 0105-4538
Rationale: Nasal allergen provocations may be useful in investigating the pathophysiologyof allergic rhinitis and effects of treatments.Objective: To use grass pollen nasal allergen challenge (NAC) to investigate theeffects of allergen immunotherapy in a cross-sectional study.Methods: We studied nasal and cutaneous responses in untreated subjects withseasonal grass-pollen allergic rhinitis (n = 14) compared with immunotherapytreatedallergics (n = 14), plus a nonatopic control group (n = 14). Volunteersunderwent a standardized NAC with 2000 biological units of timothy grass allergen(equivalent to 1.3 lg major allergen, Phl p5). Nasal fluid was collected andanalysed by ImmunoCAP and multiplex assays. Clinical response was assessed bysymptom scores and peak nasal inspiratory flow (PNIF). Cutaneous response wasmeasured by intradermal allergen injection. Retrospective seasonal symptomquestionnaires were also completed.Results: Immunotherapy-treated patients had lower symptom scores (P = 0.04)and higher PNIF (P = 0.02) after challenge than untreated allergics. They hadreduced early (P = 0.0007) and late (P < 0.0001) skin responses, and lower retrospectiveseasonal symptom scores (P < 0.0001). Compared to untreated allergics,immunotherapy-treated patients had reduced nasal fluid concentrations of IL-4,IL-9 and eotaxin (all P < 0.05, 8 h level and/or area under the curve comparison),and trends for reduced IL-13 (P = 0.07, area under the curve) and earlyphasetryptase levels (P = 0.06).Conclusions: Nasal allergen challenge is sensitive in the detection of clinical andbiological effects of allergen immunotherapy and may be a useful surrogate markerof treatment efficacy in future studies.
Dodev TS, Bowen H, Shamji MH, et al., 2015, Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class, ALLERGY, Vol: 70, Pages: 720-724, ISSN: 0105-4538
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- Citations: 46
Santos AF, James LK, Bahnson HT, et al., 2015, IgG<sub>4</sub> inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 135, Pages: 1249-1256, ISSN: 0091-6749
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- Citations: 181
Shamji MH, Layhadi JA, Scadding GW, et al., 2015, Basophil expression of diamine oxidase: A novel biomarker of allergen immunotherapy response, Journal of Allergy and Clinical Immunology, Vol: 135, Pages: 913-921.e9, ISSN: 0091-6749
BackgroundImmunotherapy inhibits basophil histamine release, but the assay is cumbersome, and no one has studied the effects of immunotherapy withdrawal.ObjectiveIntracellular fluorochrome-labeled diamine oxidase (DAO) was used as a novel functional readout of basophil histamine release after immunotherapy. Results were compared with conventional basophil surface expression of activation markers.MethodsSubcutaneous immunotherapy (SCIT)–treated patients (n = 14), sublingual immunotherapy (SLIT)–treated patients (n = 12), participants who completed 3 years of treatment with grass pollen sublingual immunotherapy (the SLIT-TOL group; n = 6), patients with untreated seasonal allergic rhinitis (SAR; n = 24), and nonatopic control subjects (n = 12) were studied. Intracellularly labeled DAO+ and surface expression of CD203cbright, CD63+, and CD107a+ on chemoattractant receptor-homologous molecule expressed on TH2 lymphocytes (CRTh2)–positive basophils were measured by means of flow cytometry. Serum IgG4 levels and serum inhibitory activity for IgE-allergen complex binding to B cells (IgE-FAB) and basophil histamine release were also determined.ResultsProportions of allergen-stimulated DAO+CRTh2+ basophils were higher in participants in the SCIT, SLIT, and SLIT-TOL groups (all P < .0001) compared with those in patients in the SAR group. Similarly, there were lower proportions of CRTh2+ basophils expressing surface CD203cbright (all P < .001), CD63 (all P < .001), and CD107a (all P < .01). Rhinitis symptoms were lower in the SCIT, SLIT, and SLIT-TOL groups (P < .001) compared with those in the SAR group. Serum inhibitory activity for IgE-FAB and basophil histamine release were also significantly greater in all immunotherapy groups (P < .05) compared with the SAR group.ConclusionThese results support long-term clinical and immunologic tolerance during and after grass pollen immunotherapy. Intracellularly labeled DAO expression by basophils m
Shamji MH, Durham SR, 2015, Measuring histamine content and release at single-cell level during venom allergy immunotherapy Reply, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 135, Pages: 1089-1090, ISSN: 0091-6749
Scadding GW, Eifan A, Penagos M, et al., 2015, Local and systemic effects of cat allergen nasal provocation, Clinical and Experimental Allergy, Vol: 45, Pages: 613-623, ISSN: 0954-7894
BackgroundCat allergen is widely distributed in homes and schools; allergic sensitization is common.ObjectiveTo develop a model of cat allergen nasal challenge to establish dose–response and time–course characteristics and investigate local and systemic biomarkers of allergic inflammation.MethodsNineteen cat‐allergic individuals underwent titrated nasal challenge, range 0.243 to 14.6 μg/mL Fel d1, and matched diluent‐only provocation. Clinical response to 8 h was assessed by symptom scores and peak nasal inspiratory flow (PNIF). Nasal fluid was collected using polyurethane sponges and analysed by ImmunoCAP and multiplex assays. Whole blood flow cytometry for basophil surface CD63, CD107a, and CD203c was carried out at baseline and 6 h post‐challenge.ResultsA dose–response to allergen was seen in symptom scores and PNIF, maximal at 10 000 BU/mL (4.87 μg/mL Fel d1), P < 0.0001 vs. diluent. Nasal fluid tryptase was elevated at 5 min after challenge (P < 0.05 vs. diluent); eotaxin, IL‐4, ‐5, ‐9, and ‐13 were increased at 8 h (P < 0.05 to P < 0.0001 vs. diluent); TSLP was undetectable; IL‐10, IL‐17A, and IL‐33 were unchanged compared to diluent challenge. Nasal fluid IL‐5 and IL‐13 correlated inversely with PNIF after challenge (IL‐5, r = −0.79, P < 0.0001; IL‐13, r = −0.60, P = 0.006). Surface expression of CD63 and CD107a was greater at 6 h than at baseline, both in the presence (both P < 0.05) and absence (CD63, P < 0.01; CD107a, P < 0.05) of in vitro allergen stimulation; no changes were seen on diluent challenge day.ConclusionsCat allergen nasal challenge produces local and systemic Th2‐driven inflammatory responses and has potential as a surrogate outcome measure in clinical trials.
Maloney J, Durham S, Skoner D, et al., 2015, Safety of sublingual immunotherapy Timothy grass tablet in subjects with allergic rhinitis with or without conjunctivitis and history of asthma, ALLERGY, Vol: 70, Pages: 302-309, ISSN: 0105-4538
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- Citations: 38
Parkin R, Varricchi G, Steveling E, et al., 2015, Interleukin-21 induced IgE-synthesis in memory B cells: a role for T follicular helper cells in seasonal allergic rhinitis, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 539-539, ISSN: 0954-7894
Lao-Araya M, Abubakar-Waziri H, Steveling E, et al., 2015, Grass pollen immunotherapy suppresses seasonal increases in type 2 innate lymphoid cells (ILC2s), Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 538-539, ISSN: 0954-7894
Abubakar-Waziri H, Parkin RV, Switzer AR, et al., 2015, Local nasal protective IgG4 antibodies: novel biomarker for monitoring allergen immunotherapy, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 539-540, ISSN: 0954-7894
Turner PJ, McMahon O, Switzer A, et al., 2015, Marked Increase in Basophil Activation during Non-Anaphylactic Allergic Reactions to Peanut in Man, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB33-AB33, ISSN: 0091-6749
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- Citations: 3
Shamji MH, Ceuppens JL, Hellings PW, et al., 2015, Immunogenicity Evaluation of Subcutaneous Administration of Peptide Hydrolysate from Lolium Perenne (gpASIT plus ™) in Combination with Bacterial HSP70 (DnaK) in Patients with Seasonal Allergic Rhinitis: A Double Blind Placebo Controlled Trial, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB159-AB159, ISSN: 0091-6749
Durham SR, Kaur A, Koch G, et al., 2015, Sustained Efficacy Assessed By Number Needed to Treat for Timothy Grass Immunotherapy Tablets in the Treatment of Allergic Rhinitis with/without Conjunctivitis up to 2 Years after 3 Years of Treatment, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB267-AB267, ISSN: 0091-6749
Santos AF, James LK, Shamji MH, et al., 2015, IgG4 inhibits peanut-induced basophil and mast cell activation in selected peanut-sensitised tolerant children, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 538-538, ISSN: 0954-7894
Shamji MH, Bellido V, Scadding GW, et al., 2015, Effector cell signature in peripheral blood following nasal allergen challenge in grass pollen allergic individuals, ALLERGY, Vol: 70, Pages: 171-179, ISSN: 0105-4538
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- Citations: 27
Nolte H, Durham SR, Nelson HS, et al., 2014, Magnitude of changes in patient symptom and medication scores in grass allergy immunotherapy trials: Dependency on levels of pollen exposure, Allergy, Asthma and Clinical Immunology, Vol: 10, ISSN: 1710-1484
James LK, Wu Y-CB, Scadding GW, et al., 2014, Mucosal antibody repertoires in allergy and the influence of allergen immunotherapy, IMMUNOLOGY, Vol: 143, Pages: 171-172, ISSN: 0019-2805
Slovick A, Durham SR, Till SJ, 2014, Grass pollen immunotherapy for treatment of allergic rhinitis, BMJ-BRITISH MEDICAL JOURNAL, Vol: 349, ISSN: 1756-1833
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- Citations: 2
Makatsori M, Scadding GW, Skypala I, et al., 2014, Silk contact anaphylaxis, CONTACT DERMATITIS, Vol: 71, Pages: 314-315, ISSN: 0105-1873
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- Citations: 8
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