Imperial College London
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ProfessorStephenDurham

Faculty of Medicine, National Heart & Lung Institute

Professor of Allergy and Respiratory
 
 
 
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Contact

 

+44 (0)20 7351 8024s.durham

 
 
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Location

 

Fulham RoadRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bousquet:2020:10.1186/s13601-020-00362-7,
author = {Bousquet, J and Cristol, J-P and Czarlewski, W and Anto, JM and Martineau, A and Haahtela, T and Fonseca, SC and Iaccarino, G and Blain, H and Fiocchi, A and Canonica, GW and Fonseca, JA and Vidal, A and Choi, H-J and Kim, HJ and Le, Moing V and Reynes, J and Sheikh, A and Akdis, CA and Zuberbier, T and Abdul, Latiff AH and Abdullah, B and Aberer, W and Abusada, N and Adcock, I and Afani, A and Agache, I and Aggelidis, X and Agustin, J and Akdis, CA and Akdis, M and Al-Ahmad, M and Al-Zahab, Bassam A and Alburdan, H and Aldrey-Palacios, O and Alvarez, Cuesta E and Alwan, Salman H and Alzaabi, A and Amade, S and Ambrocio, G and Angles, R and Annesi-Maesano, I and Ansotegui, IJ and Anto, JM and Ara, Bardajo P and Arasi, S and Arrais, M and Arshad, H and Artesani, M-C and Asayag, E and Avolio, F and Azhari, K and Bachert, C and Bagnasco, D and Baiardini, I and Bajrovic, N and Bakakos, P and Bakeyala, Mongono S and Balotro-Torres, C and Barba, S and Barbara, C and Barbosa, E and Barreto, B},
doi = {10.1186/s13601-020-00362-7},
journal = {Clinical and Translational Allergy},
pages = {1--18},
title = {Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies},
url = {http://dx.doi.org/10.1186/s13601-020-00362-7},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
AU  - Bousquet,J
AU  - Cristol,J-P
AU  - Czarlewski,W
AU  - Anto,JM
AU  - Martineau,A
AU  - Haahtela,T
AU  - Fonseca,SC
AU  - Iaccarino,G
AU  - Blain,H
AU  - Fiocchi,A
AU  - Canonica,GW
AU  - Fonseca,JA
AU  - Vidal,A
AU  - Choi,H-J
AU  - Kim,HJ
AU  - Le,Moing V
AU  - Reynes,J
AU  - Sheikh,A
AU  - Akdis,CA
AU  - Zuberbier,T
AU  - Abdul,Latiff AH
AU  - Abdullah,B
AU  - Aberer,W
AU  - Abusada,N
AU  - Adcock,I
AU  - Afani,A
AU  - Agache,I
AU  - Aggelidis,X
AU  - Agustin,J
AU  - Akdis,CA
AU  - Akdis,M
AU  - Al-Ahmad,M
AU  - Al-Zahab,Bassam A
AU  - Alburdan,H
AU  - Aldrey-Palacios,O
AU  - Alvarez,Cuesta E
AU  - Alwan,Salman H
AU  - Alzaabi,A
AU  - Amade,S
AU  - Ambrocio,G
AU  - Angles,R
AU  - Annesi-Maesano,I
AU  - Ansotegui,IJ
AU  - Anto,JM
AU  - Ara,Bardajo P
AU  - Arasi,S
AU  - Arrais,M
AU  - Arshad,H
AU  - Artesani,M-C
AU  - Asayag,E
AU  - Avolio,F
AU  - Azhari,K
AU  - Bachert,C
AU  - Bagnasco,D
AU  - Baiardini,I
AU  - Bajrovic,N
AU  - Bakakos,P
AU  - Bakeyala,Mongono S
AU  - Balotro-Torres,C
AU  - Barba,S
AU  - Barbara,C
AU  - Barbosa,E
AU  - Barreto,B
AU  - Bartra,J
AU  - Basagana,X
AU  - Bateman,ED
AU  - Battur,L
AU  - Bedbrook,A
AU  - Bedolla,Barajas M
AU  - Beghe,B
AU  - Bekere,A
AU  - Bel,E
AU  - Ben,Kheder A
AU  - Benson,M
AU  - Berghea,E-C
AU  - Bergmann,K-C
AU  - Bernardini,R
AU  - Bernstein,D
AU  - Bewick,M
AU  - Bialek,S
AU  - Bialoszewski,A
AU  - Bieber,T
AU  - Billo,NE
AU  - Bilo,M-B
AU  - Bindslev-Jensen,C
AU  - Bjermer,L
AU  - Blain,H
AU  - Bobolea,I
AU  - Bochenska,Marciniak M
AU  - Bond,C
AU  - Boner,A
AU  - Bonini,M
AU  - Bonini,S
AU  - Bosnic-Anticevich,S
AU  - Bosse,I
AU  - Botskariova,S
AU  - Bouchard,J
AU  - Boulet,L-P
AU  - Bourret,R
AU  - Bousquet,P
AU  - Braido,F
AU  - Briggs,A
AU  - Brightling,CE
AU  - Brozek,J
AU  - Brussino,L
AU  - Buhl,R
AU  - Bumbacea,R
AU  - Buquicchio,R
AU  - Burguete,Cabanas M-T
AU  - Bush,A
AU  - Busse,WW
AU  - Buters,J
AU  - Caballero-Fonseca,F
AU  - Calderon,MA
AU  - Calvo,M
AU  - Camargos,P
AU  - Camuzat,T
AU  - Canevari,FR
AU  - Cano,A
AU  - Canonica,GW
AU  - Capriles-Hulett,A
AU  - Caraballo,L
AU  - Cardona,V
AU  - Carlsen,K-H
AU  - Carmona,Pirez J
AU  - Caro,J
AU  - Carr,W
AU  - Carreiro-Martins,P
AU  - Carreon-Asuncion,F
AU  - Carriazo,A-M
AU  - Carrion,y Ribas C
AU  - Casale,T
AU  - Castor,M-A
AU  - Castro,E
AU  - Caviglia,AG
AU  - Cecchi,L
AU  - Cepeda,Sarabia A
AU  - Chalubinski,M
AU  - Chandrasekharan,R
AU  - Chang,Y-S
AU  - Chato-Andeza,V
AU  - Chatzi,L
AU  - Chatzidaki,C
AU  - Chavannes,NH
AU  - Chaves,Loureiro C
AU  - Chavez,Garcia A-A
AU  - Chelninska,M
AU  - Chen,Y
AU  - Cheng,L
AU  - Chinthrajah,S
AU  - Chivato,T
AU  - Chkhartishvili,E
AU  - Christoff,G
AU  - Chrystyn,H
AU  - Chu,DK
AU  - Chua,A
AU  - Chuchalin,A
AU  - Chung,KF
AU  - Ciceran,A
AU  - Cingi,C
AU  - Ciprandi,G
AU  - Cirule,I
AU  - Coelho
DO  - 10.1186/s13601-020-00362-7
EP  - 18
PY  - 2020///
SN  - 2045-7022
SP  - 1
TI  - Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
T2  - Clinical and Translational Allergy
UR  - http://dx.doi.org/10.1186/s13601-020-00362-7
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000595576200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://ctajournal.biomedcentral.com/articles/10.1186/s13601-020-00362-7#article-info
UR  - http://hdl.handle.net/10044/1/85651
VL  - 10
ER  -
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