Publications
101 results found
Ouyang F, Ernst S, Vogtmann T, et al., 2002, Characterization of Reentrant Circuits in Left Atrial Macroreentrant Tachycardia, Circulation, Vol: 105, Pages: 1934-1942, ISSN: 0009-7322
<jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Background</jats:italic> </jats:bold> — </jats:italic> </jats:bold> Left atrial macroreentrant tachycardia (LAMRT) has not been characterized in detail. </jats:p> <jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Methods and Results</jats:italic> </jats:bold> — </jats:italic> </jats:bold> Twenty-eight patients with LAMRT, including 4 patients with ablated typical atrial flutter (AFL), underwent electroanatomic mapping of the left atrium (LA) between February 1999 and October 2001. LA maps were performed during LAMRT in 26 patients and during sinus rhythm in 2 patients. Electrically silent areas or continuous lines of double potentials were identified as acquired anatomic barriers in all patients. In 23 of 26 patients with LAMRT mapping, 42 reentry circuits with a protected isthmus were identified. The isthmus was 11.8±5.9 mm wide, with the maximal amplitude of 0.07 to 3.61 mV. Radiofrequency pulses terminated all LAMRTs in 23 patients and resulted in conduction block across the isthmus in 20 patients. In 2 patients with sinus mapping, all identified isthmuses were ablated. Additionally, AFL was induced and ablated in 6 patients. Atrial tachycardia recurred in 4 patients: 3 patients without validated block across the isthmus presented with recurrence of the same LAMRT, and 1 patient without ablated cavotricuspid isthmus presented with AFL. All tachycardias were abolished during a second procedure. Of 25 patients with identified isthmuses, 20 patients were without atrial arrhythmia and 5 had only atrial fibrillati
Ouyang F, Fotuhi P, Ho SY, et al., 2002, Repetitive monomorphic ventricular tachycardia originating from the aortic sinus cusp - Electrocardiographic characterization for guiding catheter ablation, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 39, Pages: 500-508, ISSN: 0735-1097
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- Citations: 394
Ouyang F, Cappato R, Ernst S, et al., 2002, Electroanatomic Substrate of Idiopathic Left Ventricular Tachycardia, Circulation, Vol: 105, Pages: 462-469, ISSN: 0009-7322
<jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Background</jats:italic> — </jats:bold> </jats:italic> </jats:bold> An abnormal potential (retroPP) from the left posterior Purkinje network has been demonstrated during sinus rhythm (SR) in some patients with idiopathic left ventricular tachycardia (ILVT). We hypothesized that this potential can specifically be identified and be a critical substrate for ILVT. </jats:p> <jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Methods and Results</jats:italic> — </jats:bold> </jats:italic> </jats:bold> In 9 patients with ILVT and 6 control patients who underwent mapping of the left ventricle during SR using 3-dimensional electroanatomic mapping, an area with retroPP was found within the posterior Purkinje fiber network only in patients with ILVT. The earliest and latest retroPP was 185.4±57.4 and 465.2±37.3 ms after Purkinje potential; in the other patient with ILVT, an entire left ventricle mapping demonstrated a slow conduction area and passive retrograde activation along the posterior fascicle during ILVT. ILVT was noninducible in 3 patients after SR mapping. Diastolic potentials critical for ILVT during ILVT coincided with the earliest retroPP during SR in 7 patients. Mechanical termination of ILVT occurred in 5 patients. A single radiofrequency pulse was applied at the site with mechanical translation in 5 patients and the site with diastolic potential in 2 patients, and 3 radiofrequency pulses were delivered to the site with the earliest retroPP in the other 3 patients without inducible ILVT after SR ma
Ouyang F, Fotuhi P, Goya M, et al., 2001, Ventricular Tachycardia Around the Tricuspid Annulus in Right Ventricular Dysplasia, Circulation, Vol: 103, Pages: 913-914, ISSN: 0009-7322
Ernst SI, Ouyang F, Goya M, et al., 2000, Catheter ablation of intermittent atrial fibrillation in the left atrium: Which line design is the best?, CIRCULATION, Vol: 102, Pages: 441-441, ISSN: 0009-7322
Antz M, Ouyang F, Volkmer M, et al., 2000, Ventricular tachycardia in arrhythmogenic right ventricular dysplasia: Can the voltage map predict the tachycardia mechanism?, CIRCULATION, Vol: 102, Pages: 675-675, ISSN: 0009-7322
Ouyang F, Ernst SI, Volkmer M, et al., 2000, Isolation of pulmonary veins to cure focally triggered atrial fibrillation: Results of short-term follow-up, CIRCULATION, Vol: 102, Pages: 443-443, ISSN: 0009-7322
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Ouyang F, Ernst SI, Volkmer M, et al., 2000, Three-dimensional electroanatomical mapping of left atrial macroreentrant tachycardia following left atrial compartmentalization in patients with atrial fibrillation, CIRCULATION, Vol: 102, Pages: 619-619, ISSN: 0009-7322
ERNST S, OUYANG F, SCHNEIDER B, et al., 2000, Prevention of Atrial Fibrillation by Complete Compartmentalization of the Left Atrium Using a Catheter Technique, Journal of Cardiovascular Electrophysiology, Vol: 11, Pages: 686-690, ISSN: 1045-3873
<jats:p>LA Compartmentalization for AF Prevention. <jats:italic>Introduction:</jats:italic> Right atrial compartmentalization has been demonstrated to only reduce the number of atrial fibrillation (AF) episodes: left atrial (LA) fibrillation still occurs.</jats:p><jats:p> <jats:italic>Methods and Results:</jats:italic> We report successful LA compartmentalization resulting in isolation of all four pulmonary veins in a 51‐year‐old woman suffering from paroxysmal AF. Deployment of a complete encircling line resulted in dissociation of electrical activation within the isolated area from the remaining LA. Despite attempts al reinduction by pacing maneuvers inside and outside the isolated area, AF was no longer inducible. During 2l‐week follow‐up, the patient remained in stable sinus rhythm with rare atrial extrasystoles.</jats:p><jats:p> <jats:italic>Conclusion:</jats:italic> If reproducible, this ablation strategy could allow treatment of AF independent of suppression of any triggering event.</jats:p>
Ernst S, Schluter M, Ouyang F, et al., 1999, Modification of the Substrate for Maintenance of Idiopathic Human Atrial Fibrillation, Circulation, Vol: 100, Pages: 2085-2092, ISSN: 0009-7322
<jats:p> <jats:italic>Background</jats:italic> —Catheter ablative techniques to modify the substrate to maintain atrial fibrillation (AF) require the creation of continuous radiofrequency current-induced ablation lines. This study was designed to assess the efficacy and safety of nonfluoroscopic mapping in this setting. </jats:p> <jats:p> <jats:italic>Methods and Results</jats:italic> —A total of 45 consecutive patients with idiopathic AF were studied. The first 13 underwent ablation confined to the left atrium by creating a circular line isolating the pulmonary vein ostia and a second line connecting the former with the mitral annulus. Subsequently, 12 of these patients underwent a procedure confined to the right atrium (RA), where attempts were made to create an isthmus line between the inferior vena cava and the tricuspid annulus, an anterior line connecting the tricuspid annulus with the superior vena cava, and an intercaval line between the ostia of the inferior and superior venae cavae. In the last 32 patients, only the RA approach was performed. Technical difficulties prevented the creation of the intended left atrial line pattern: all patients experienced recurrences. A 100% recurrence rate was also observed after subsequent RA ablation, despite creation of a complete line pattern in 4 of 12 patients. Of the final 32 patients, AF recurred in 94%; a complete ablation line pattern had been achieved in 18 patients (56%), 16 of whom had recurrences. </jats:p> <jats:p> <jats:italic>Conclusions</jats:italic> —The electroanatomically-guided creation of extended radiofrequency current lesions is technically feasible only in the RA. However, procedural success in the RA does not suppress recurrences of AF in the majority of patients. </jats:p>
Ernst SIS, 1998, Calcitonin gene-related peptide mediates the protective effect of sensory nerves in a model of colonic injury, J Pharmacol Exp Ther.
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