Imperial College London

DrSarahEssilfie-Quaye

Faculty of MedicineFaculty of Medicine Centre

Project Manager in Research Strategy
 
 
 
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Contact

 

+44 (0)20 7594 2857s.essilfie-quaye Website

 
 
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Location

 

Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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11 results found

Footitt J, Mallia P, Durham AL, Ho WE, Trujillo-Torralbo MB, Telcian AG, Del Rosario A, Chang C, Peh HY, Kebadze T, Aniscenko J, Stanciu L, Essilfie-Quaye S, Ito K, Barnes PJ, Elkin SL, Kon OM, Wong WS, Adcock IM, Johnston SLet al., 2016, Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD., Chest, Vol: 149, Pages: 62-73, ISSN: 1931-3543

BACKGROUND: Respiratory virus infections are commonly associated with COPD exacerbations, but little is known about the mechanisms linking virus infection to exacerbations. Pathogenic mechanisms in stable COPD include oxidative and nitrosative stress and reduced activity of histone deacetylase-2 (HDAC2), but their roles in COPD exacerbations is unknown. We investigated oxidative and nitrosative stress (O&NS) and HDAC2 in COPD exacerbations using experimental rhinovirus infection. METHODS: Nine subjects with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II), 10 smokers, and 11 nonsmokers were successfully infected with rhinovirus. Markers of O&NS-associated cellular damage, and inflammatory mediators and proteases were measured in sputum, and HDAC2 activity was measured in sputum and bronchoalveolar macrophages. In an in vitro model, monocyte-derived THP-1 cells were infected with rhinovirus and nitrosylation and activity of HDAC2 was measured. RESULTS: Rhinovirus infection induced significant increases in airways inflammation and markers of O&NS in subjects with COPD. O&NS markers correlated with virus load and inflammatory markers. Macrophage HDAC2 activity was reduced during exacerbation and correlated inversely with virus load, inflammatory markers, and nitrosative stress. Sputum macrophage HDAC2 activity pre-infection was inversely associated with sputum virus load and inflammatory markers during exacerbation. Rhinovirus infection of monocytes induced nitrosylation of HDAC2 and reduced HDAC2 activity; inhibition of O&NS inhibited rhinovirus-induced inflammatory cytokines. CONCLUSIONS: O&NS, airways inflammation, and impaired HDAC2 may be important mechanisms of virus-induced COPD exacerbations. Therapies targeting these mechanisms offer potential new treatments for COPD exacerbations.

Journal article

Durham AL, Footitt J, Essilfie-Quaye S, Telcian AG, Mallia P, Ito K, Barnes PJ, Johnston S, Adcock IMet al., 2015, LSC Abstract - Rhinovirus infection induces NRF2 in monocytes but not in epithelial cells, via distinct intracellular pathways, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Footitt J, Mallia P, Durham A, Trujillo-Torralbo MB, Telcian A, Kebadze T, Aniscenko J, Essilfie-Quaye S, Ito K, Barnes PJ, Elkin S, Kon OM, Adcock I, Johnston SLet al., 2013, HDAC ACTIVITY IN MACROPHAGES IN EXPERIMENTAL RHINOVIRUS INFECTION IN COPD, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A58-A59, ISSN: 0040-6376

Conference paper

Haque R, Hakim A, Moodley T, Torrego A, Essilfie-Quaye S, Jazrawi E, Johnson M, Barnes PJ, Adcock IM, Usmani OSet al., 2013, Inhaled long-acting beta(2) agonists enhance glucocorticoid receptor nuclear translocation and efficacy in sputum macrophages in COPD, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 132, Pages: 1166-1173, ISSN: 0091-6749

Journal article

Essilfie-Quaye S, Ito K, Ito M, Kharitonov SA, Barnes PJet al., 2011, Comparison of Symbicort (R) versus Pulmicort (R) on steroid pharmacodynamic markers in asthma patients, RESPIRATORY MEDICINE, Vol: 105, Pages: 1784-1789, ISSN: 0954-6111

Journal article

Durham A, Essilfie-Quaye S, Ngjelo A, Barnes PJ, Adcock IMet al., 2010, Female Sex Hormones Modulate Inflammatory Mediator Expression From Bronchial Epithelial Cells, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, ISSN: 1073-449X

Journal article

Essilfie-Quaye S, Barnes PJ, Ito K, 2009, Glucocorticoid Receptor Acetylation in Patients with COPD., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X

Journal article

Maneechotesuwan K, Essilfie-Quaye S, Kharitonov SA, Adcock IM, Barnes PJet al., 2007, Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils, CHEST, Vol: 132, Pages: 98-105, ISSN: 0012-3692

Journal article

Ito K, Yamamura S, Essilfie-Quaye S, Cosio B, Ito M, Barnes PJ, Adcock IMet al., 2006, Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappa B suppression, Journal of Experimental Medicine, Vol: 203, Pages: 7-13, ISSN: 1540-9538

Journal article

Maneechotesuwan K, Essilfie-Quaye S, Meah S, Kelly C, Kharitonov SA, Adcock IM, Barnes PJet al., 2005, Formoterol attenuates neutrophilic airway inflammation in asthma, CHEST, Vol: 128, Pages: 1936-1942, ISSN: 0012-3692

Journal article

Basoglu OK, Pelleg A, Essilfie-Quaye S, Brindicci C, Barnes PJ, Kharitonov SAet al., 2005, Effects of aerosolized adenosine 5 '-triphosphate vs adenosine 5 '-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma, CHEST, Vol: 128, Pages: 1905-1909, ISSN: 0012-3692

Journal article

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